Combined Nutrient Intake and Muscle Protein Synthesis

Sponsor

Maastricht University Medical Center (Other)

Overall Status

Completed

CT.gov ID

NCT01239277

Collaborator

(none)

Enrollment

Location

Arms

5.9

Duration (Months)

8.1

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Dietary intervention to prevent sarcopenia in elderly people. The objective of this study is to test whether combined nutrient intake plays an important role in stimulation of the muscle protein growth in elderly people; and whether it represent effective strategies to overcome the impaired muscle protein synthesis in elderly when compared with young subjects.

Condition or Disease	Intervention/Treatment	Phase
Aging	Other: protein Other: protein and carbohydrate Other: protein and leucine	N/A

Study Design

Study Type:

Interventional

Actual Enrollment :

48 participants

Allocation:

Randomized

Intervention Model:

Parallel Assignment

Masking:

Double (Participant, Investigator)

Primary Purpose:

Prevention

Official Title:

Combined Nutrient Intake and Muscle Protein Synthesis

Study Start Date :

Jan 1, 2011

Actual Primary Completion Date :

Jul 1, 2011

Actual Study Completion Date :

Jul 1, 2011

Arms and Interventions

Arm	Intervention/Treatment
Experimental: protein (elderly)	Other: protein 20g protein
Experimental: protein and carbohydrate (elderly)	Other: protein and carbohydrate 20g protein and 20g carbohydrate
Experimental: protein and carbohydrate (young)	Other: protein and carbohydrate 20g protein and 20g carbohydrate
Experimental: protein and leucine (elderly)	Other: protein and leucine 20g protein, 2.5g leucine

Outcome Measures

Primary Outcome Measures

Muscle protein synthesis [6 h postprandial period]
Muscle protein synthesis will be expressed as fractional synthetic rate (FSR) by dividing the increment in enrichment in the product, i.e. protein-bound C13phe, by the enrichment of the precursor (=plasma availability).

Eligibility Criteria

Criteria

Ages Eligible for Study:

70 Years to 85 Years

Sexes Eligible for Study:

Male

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

males
70-85 years or 18-30 years
BMI < 30

Exclusion Criteria:

Type II diabetes
All co morbidities interacting with mobility and muscle metabolism of the lower limbs
Use of anticoagulants
Patients suffering from Phenylketonuria
Participation in any regular exercise programme