Effect of Ageing on Airway Remodeling

• Sponsor: University Hospital, Montpellier (Other)
• Overall Status: Terminated
• CT.gov ID: NCT01230879
• Collaborator: (none)
• Enrollment: 101
• Location: 1
• Arms: 3
• Duration (Months): 36.6
• Patients Per Site Per Month: 2.8

Study Details

Study Description

Brief Summary

The aim of the study is to investigate the relationship between aging and morphological changes in the lung. 120 consecutive healthy volunteers over 60 years will be enrolled for this trial.

Condition or Disease	Intervention/Treatment	Phase
Aging	Other: EFR and TDM	N/A

Detailed Description

Chest multidetector CT without injection and spirometry data will be obtained from a multicentric sample of individuals between 60 and 95 years of ageExclusion criteria were current smoking, history of smoking within the past 10 years, any known chronic or acute pulmonary disease. Individuals treated with Amiodarone, Bleomycin or methotrexate were excludedOutcome

Study Design

• Study Type: Interventional
• Actual Enrollment: 101 participants
• Allocation: Non-Randomized
• Intervention Model: Single Group Assignment
• Masking: None (Open Label)
• Primary Purpose: Diagnostic
• Official Title: Study of Bronchoalveolar Lung Remodeling in Subjects From 60 Years Free of Progressive Lung Disease: Structure-function Analysis
• Study Start Date: Jul 15, 2009
• Actual Primary Completion Date: Aug 1, 2012
• Actual Study Completion Date: Aug 1, 2012

Arms and Interventions

Arm	Intervention/Treatment
Experimental: 60 - 70 years old EFR and TDM	Other: EFR and TDM; EFR : Pulmonary function test TDM : tomodensitometry
Experimental: 71 - 80 years old EFR and TDM	Other: EFR and TDM; EFR : Pulmonary function test TDM : tomodensitometry
Experimental: 81 - 95 years old EFR and TDM	Other: EFR and TDM; EFR : Pulmonary function test TDM : tomodensitometry

Outcome Measures

Primary Outcome Measures

1. Bronchial wall thickness [1 day]

   Bronchial wall thickness and remodeling associated with aging

Eligibility Criteria

Criteria

• Ages Eligible for Study: 60 Years to 95 Years
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: Yes

Inclusion Criteria:

• People from 60 to 95 years old free from chest disease or history of chest disease

Exclusion Criteria:

• Chronic cough

• Dyspnea

• Sinonasal or chest infection during enrollment

• Myocardial infarction.

• Current smoker or past smoker with more than 10 pack year intoxication

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	University Montpellier Hospital	Montpellier		France	34295

Sponsors and Collaborators

• University Hospital, Montpellier

Investigators

• Principal Investigator: BOMMART Sebastien, MD, University Montpellier Hospital

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: University Hospital, Montpellier
• ClinicalTrials.gov Identifier: NCT01230879
• Other Study ID Numbers: 8268
• First Posted: Oct 29, 2010
• Last Update Posted: Nov 30, 2021
• Last Verified: Nov 1, 2021

• Keywords provided by University Hospital, Montpellier: Aging lung; Airway remodeling; Airway segmentation; Chest CT
• Additional relevant MeSH terms: Airway Remodeling

Study Results

No Results Posted as of Nov 30, 2021