PPS: Implementing a Physical and Cognitive Performance Assessment Cohort in the MURDOCK Study Community Registry and Biorepository

Sponsor

Duke University (Other)

Overall Status

Completed

CT.gov ID

NCT01720472

Collaborator

(none)

1,000

Enrollment

Locations

75.9

Duration (Months)

166.7

Patients Per Site

2.2

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The purpose of this study is to use the MURDOCK Horizon 1.5 infrastructure (Duke Instutional Review Board Pro00011196) to specifically target and enroll 1,000 participants across age groups and other demographic categories in order to develop a diverse cohort with specific physical and cognitive performance data paired with biological samples.

Condition or Disease	Intervention/Treatment	Phase
Aging Physical Functioning Cognitive Functioning Fitness	Genetic: Biomarker studies

Detailed Description

The MURDOCK Study, proposes this Horizon 2 study to collect a brief physical and cognitive performance assessment from 1,000 MURDOCK Registry participants. Blood sample aliquots will also be obtained. These physical and cognitive performance data, paired with -omics data from plasma and serum sample analyses, offer promise in the discovery of biomarkers for functional decline. This research will provide an important basis for our understanding of the physical, lifestyle, and genetic factors which, over the lifespan, contribute to changes in physical and cognitive capabilities as we age.

Study Design

Study Type:

Observational [Patient Registry]

Actual Enrollment :

1000 participants

Observational Model:

Cohort

Time Perspective:

Prospective

Official Title:

Implementing a Physical and Cognitive Performance Assessment Cohort in the MURDOCK Study Community Registry and Biorepository

Study Start Date :

May 1, 2012

Actual Primary Completion Date :

Aug 28, 2018

Actual Study Completion Date :

Aug 28, 2018

Arms and Interventions

Arm	Intervention/Treatment
Community, Physical Performance	Genetic: Biomarker studies

Arm

Intervention/Treatment

Community, Physical Performance

Genetic: Biomarker studies

Outcome Measures

Primary Outcome Measures

Implementing a Physical and Cognitive Performance Assessment Cohort in the MURDOCK Study Community Registry and Biorepository [Upto 2 years or 24 months]
Factors associated with physical function and physical activity and change in physical activity and function over two-year follow-up.

Eligibility Criteria

Criteria

Ages Eligible for Study:

30 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

A resident of Cabarrus County and/or the city of Kannapolis (and surrounding regions) or certain portions of Rowan, Mecklenburg, or Stanly counties in North Carolina for 6 or more months of the year.
Age 30 or older

Exclusion Criteria:

Female that is currently pregnant
Having had a heart attack, angina, congestive heart failure, or fluid in the lungs within the past 6 months
Participant that requires consent by a legally authorized representative
Participant that cannot walk 30ft without human assistance

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Bethesda Health Center	Charlotte	North Carolina	United States	28262
2	McGill Family Medicine	Concord	North Carolina	United States	28025
3	Carolinas Medical Center NorthEast Medical Arts Building	Concord	North Carolina	United States	28205
4	Ada Jenkins Center	Davidson	North Carolina	United States	28036
5	Harrisburg Sleep Center	Harrisburg	North Carolina	United States	28075
6	Lake Norman Community Health Clinic	Huntersville	North Carolina	United States	28078