Effect of Exercise Intervention on Various Physiologic Factors That Change With Increasing Age

• Sponsor: Mayo Clinic (Other)
• Overall Status: Completed
• CT.gov ID: NCT00283673
• Collaborator: (none)
• Enrollment: 102
• Location: 1
• Duration (Months): 28
• Patients Per Site Per Month: 3.6

Study Details

Study Description

Brief Summary

This study randomized healthy sedentary people age 20-80 years to 16 weeks of supervised exercise versus no exercise. Several end points were evaluated after 16 weeks including insulin sensitivity and muscle physiology.

Condition or Disease	Intervention/Treatment	Phase
Aging	Behavioral: Exercise	N/A

Detailed Description

Healthy subjects performing < 30 min exercise twice per week were studied prior to randomization and after of sixteen weeks exercise. They were randomized to sixteen weeks of supervised exercise performed on a stationary bike vs. placebo exercise (a series of flexibility exercises performed at home). Intensity, duration and frequency of exercise were gradually increased to four sessions per week lasting forty minutes each and achieving 80% target heart rate. Participants were weighed perioidically and counseled appropriately when weight changed by > 2 %. Insulin sensitivity and muscle mitochondrial protein synthesis were studied.

Study Design

• Study Type: Interventional
• Allocation: Randomized
• Intervention Model: Parallel Assignment
• Masking: Single
• Official Title: Impact of Aerobic Exercise Training on Age Related Changes in Insulin Sensitivity and Muscle Oxidative Capacity
• Study Start Date: Sep 1, 1995
• Actual Primary Completion Date: Jan 1, 1998
• Actual Study Completion Date: Jan 1, 1998

Outcome Measures

Primary Outcome Measures

1. Insulin sensitivity []

Secondary Outcome Measures

1. Muscle Mitochondrial Protein Synthesis []

2. mRNA of mitochondrial genes []

3. mRNA of genes involved in mitochondrial biogenesis []

Eligibility Criteria

Criteria

• Ages Eligible for Study: 20 Years to 90 Years
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: Yes

Healthy subjects performing < 30 min exercise twice per week. Age 20-90 years. Willing to be randomized to exercise versus no exercise. Willing to be studied in General Clinical Research Center with studies including Muscle Biopsy.

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Mayo Clinic	Rochester	Minnesota	United States	55905

Sponsors and Collaborators

• Mayo Clinic

Investigators

• Principal Investigator: K. Sreekumaran Nair, M.D., Mayo Clinic

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• ClinicalTrials.gov Identifier: NCT00283673
• Other Study ID Numbers: 350-95; R01AG009531
• First Posted: Jan 30, 2006
• Last Update Posted: Jun 6, 2011
• Last Verified: Jun 1, 2011

Study Results

No Results Posted as of Jun 6, 2011