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STARR: The South Texas Aging Registry and Repository

Sponsor
The University of Texas Health Science Center at San Antonio (Other)
Overall Status
Recruiting
CT.gov ID
NCT05835388
Collaborator
(none)
999
Enrollment
1
Location
141.6
Anticipated Duration (Months)
7.1
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

This research registry and repository was designed because the investigators want to learn about how to improve the health and quality of life of older adults.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    The South Texas Aging Registry and Repository (STARR) is a database and specimen resource of community dwelling adults from the South Texas area who are interested in volunteering for research studies on aging. The goal is to assist in the inclusion of older adults in clinical research studies and to help to increase the quantity and quality of research relating to them. This registry and repository can be used for various purposes ranging from describing the natural history of aging, identifying risk factors for premature aging, and the real-world effectiveness of life-extending therapies. Collection and storage of biological samples and patient-reported data from of Individuals can help advance research and the development of new awareness of basic mechanisms that play a part in healthy aging or premature death.

    Study Design

    Study Type:
    Observational [Patient Registry]
    Anticipated Enrollment :
    999 participants
    Observational Model:
    Other
    Time Perspective:
    Prospective
    Official Title:
    The South Texas Aging Registry and Repository (STARR)
    Actual Study Start Date :
    Feb 11, 2019
    Anticipated Primary Completion Date :
    Dec 1, 2029
    Anticipated Study Completion Date :
    Dec 1, 2030

    Arms and Interventions

    Arm Intervention/Treatment
    Primary Study

    Community dwelling adults from the South Texas area who are interested in volunteering for research studies on aging. This will facilitate the inclusion of older adults and minority in research studies and help to increase the quantity and quality of research relating to them.
    KAPP Sen Tissue Mapping Study

    The substudy KAPP Sen TMC will enroll eligible STARR participants to undergo repeat assessments over two years. KAPP Sen TMC is a collaborative effort between UT Health San Antonio, Jackson Laboratory for Genomic Medicine (JAX-GM), Brigham and Women's Hospital, Joslin Diabetes Center, UConn Health Center on Aging and Mayo Clinic to characterize cellular senescence in terms of its presence and heterogeneity in healthy human tissues, as well as its tissue burden, spatial distribution, and biological features in a diverse study population.

    Outcome Measures

    Primary Outcome Measures

    1. Collection of STARR repository data [Baseline to one day]

      De-identified repository data and samples will be made available to outside investigators for future studies related to aging

    Secondary Outcome Measures

    1. KAPP Sen TMC repository data [Baseline to one year]

      Eligible STARR participants to undergo repeat assessments to characterize cellular senescence

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    Yes
    Inclusion Criteria STARR:

    -Age 18 years or older

    Inclusion Criteria KAPP Sen TMC:

    -Age 20 years and older

    Exclusion Criteria STARR:

    • Inability to provide informed consent

    • Pregnancy

    Exclusion Criteria KAPP Sen Tissue Mapping Center (TMC) Study:

    • Diabetes

    • Hypertension with end-organ damage

    • BMI>30

    • GFR<60 ml/min/1.73 m2

    • Cardiovascular disease

    • Pancreatitis

    • Malignancy other than non-melanoma skin cancers

    • Active, uncontrolled pulmonary, hepatic, infectious, gastrointestinal, endocrine, neurologic, or inflammatory disease.

    • Chronic use of systemic steroids or use of agents with senolytic activity

    • Any disease or condition considered to be exclusionary based on the clinical option and discretion of PI

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 The University of Texas Health Science Center at San Antonio San Antonio Texas United States 78229

    Sponsors and Collaborators

    • The University of Texas Health Science Center at San Antonio

    Investigators

    • Principal Investigator: Sara Espinoza, MD, University of Texas Health Science Center San Antonio

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    The University of Texas Health Science Center at San Antonio
    ClinicalTrials.gov Identifier:
    NCT05835388
    Other Study ID Numbers:
    • HSC20150610H
    First Posted:
    Apr 28, 2023
    Last Update Posted:
    Apr 28, 2023
    Last Verified:
    Apr 1, 2023
    Individual Participant Data (IPD) Sharing Statement:
    Yes
    Plan to Share IPD:
    Yes
    Studies a U.S. FDA-regulated Drug Product:
    No
    Studies a U.S. FDA-regulated Device Product:
    No
    Keywords provided by The University of Texas Health Science Center at San Antonio
    Older adults
    Genetic material
    Biorepository

    Study Results

    No Results Posted as of Apr 28, 2023