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Efficacy Testing of Crassocephalum Rabens Extract Capsules

Sponsor
Greenyn Biotechnology Co., Ltd. (Industry)
Overall Status
Completed
CT.gov ID
NCT05309161
Collaborator
Chia Nan University of Pharmacy ＆ Science (Other)
40
Enrollment
1
Location
2
Arms
3.5
Actual Duration (Months)
11.3
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

This study is to investigate the improveing effects of the Crassocephalum rebens extract on skin conditions in normal people.

Condition or Disease Intervention/Treatment Phase
  • Dietary Supplement: Crassocephalum rabens extract
 N/A

Study Design

Study Type:
Interventional
Actual Enrollment :
40 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
Double (Participant, Investigator)
Primary Purpose:
Other
Official Title:
Efficacy Testing of Crassocephalum Rabens Extract Capsules
Actual Study Start Date :
Mar 14, 2022
Actual Primary Completion Date :
Jun 30, 2022
Actual Study Completion Date :
Jun 30, 2022

Arms and Interventions

Arm Intervention/Treatment
Placebo Comparator: A group (placebo)

Placebo

Dietary Supplement: Crassocephalum rabens extract
dosage: a capsule (180 mg)/day; duration: 1 month
Active Comparator: B group (experimental)

Crassocephalum rabens extract

Dietary Supplement: Crassocephalum rabens extract
dosage: a capsule (180 mg)/day; duration: 1 month

Outcome Measures

Primary Outcome Measures

  1. Measurement of skin hydration [Week 0]

    Corneometer CM825 is used to measure the moisture of upper cheek (unit: Corneometer® unit)

  2. Measurement of skin hydration [Week 4]

    Corneometer CM825 is used to measure the moisture of upper cheek (unit: Corneometer® unit)

  3. Measurement of skin brightness [Week 0]

    Chroma Meter MM500 is employed to measure the brightness of upper cheek (unit: L* value (L* range: 0-100)).

  4. Measurement of skin brightness [Week 4]

    Chroma Meter MM500 is employed to measure the brightness of upper cheek (unit: L* value (L* range: 0-100)).

  5. Measurement of skin texture [Week 0]

    Visia® skin analysis system is used to measure the skin texture of full face (unit: number of fine lines)

  6. Measurement of skin texture [Week 4]

    Visia® skin analysis system is used to measure the skin texture of full face (unit: number of fine lines)

  7. Measurement of skin spots [Week 0]

    Visia® skin analysis system is used to measure the skin spots of full face (unit: number of spots)

  8. Measurement of skin spots [Week 4]

    Visia® skin analysis system is used to measure the skin spots of full face (unit: number of spots)

  9. Measurement of collagen content [Week 0]

    DermaLab® Series SkinLab Combo (Cortex) is employed to measure skin collagen content of upper cheek (unit: collagen density)

  10. Measurement of collagen content [Week 4]

    DermaLab® Series SkinLab Combo (Cortex) is employed to measure skin collagen content of upper cheek (unit: collagen density)

  11. Measurement of Crow's feet [Week 0]

    Visia® skin analysis system is used to measure the skin spots of full face (unit: number of Visia® skin analysis system is used to measure the skin spots of full face (unit: number of fine lines around eyes)

  12. Measurement of Crow's feet [Week 4]

    Visia® skin analysis system is used to measure the skin spots of full face (unit: number of Visia® skin analysis system is used to measure the skin spots of full face (unit: number of fine lines around eyes)

  13. Measurement of skin elasticity [Week 0]

    Cutometer® is used to measure the skin elasticity of upper cheek (unit: mm)

  14. Measurement of skin elasticity [Week 4]

    Cutometer® is used to measure the skin elasticity of upper cheek (unit: mm)

  15. Measurement of skin wrinkles [Week 0]

    Visia® skin analysis system is used to measure the skin wrinkles of full face (unit: number of wrinkles)

  16. Measurement of skin wrinkles [Weeks 4]

    Visia® skin analysis system is used to measure the skin wrinkles of full face (unit: number of wrinkles)

  17. Measurement of skin pores [Week 0]

    Visia® skin analysis system is used to measure the skin spots of full face (unit: number of pores)

  18. Measurement of skin pores [Week 4]

    Visia® skin analysis system is used to measure the skin spots of full face (unit: number of pores)

Eligibility Criteria

Criteria

Ages Eligible for Study:
20 Years and Older
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
Yes
Inclusion Criteria:

  1. Age over 20 years

  2. Healthy people

Exclusion Criteria:

  1. Non-volunteer

  2. Pregnant and lactating women

  3. Hypersensitivity to the assigned product

  4. Diagnosed with skin diseases, liver diseases, kinedy disease, and other severe diseases

  5. Cosmetic, drug, or food allergies

  6. Concurrent aesthetic treatments (e.g., intense pulse light, medical peelings, or laser therapy)

  7. Aceepted aesthetic treatments one month ago before the study

  8. Chronic sun exposure (over 3 hours/day)

  9. The members of the research team

Contacts and Locations

Locations

Site City State Country Postal Code
1 Chia Nan University of Pharmacy ＆ Science Tainan Taiwan 71710

Sponsors and Collaborators

  • Greenyn Biotechnology Co., Ltd.
  • Chia Nan University of Pharmacy ＆ Science

Investigators

  • Principal Investigator: Chia-Hua Liang, Department of Cosmetic Science, Chia Nan University of Pharmacy ＆ Science

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
Greenyn Biotechnology Co., Ltd.
ClinicalTrials.gov Identifier:
NCT05309161
Other Study ID Numbers:
  • 21-129-A
First Posted:
Apr 4, 2022
Last Update Posted:
Aug 3, 2022
Last Verified:
Mar 1, 2022
Individual Participant Data (IPD) Sharing Statement:
No
Plan to Share IPD:
No
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No

Study Results

No Results Posted as of Aug 3, 2022