Maraviroc and NeuroAIDS Pathogenesis

Sponsor

University of Hawaii (Other)

Overall Status

Completed

CT.gov ID

NCT02159027

Collaborator

ViiV Healthcare (Industry), University of Puerto Rico (Other)

Enrollment

Locations

Arms

44.1

Actual Duration (Months)

Patients Per Site

0.5

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Maraviroc is an antiretroviral medication that may help in improving mental function in HIV infected patients with mental problems by decreasing inflammatory tendencies. We will test this in a clinical trial of 42 HIV infected individuals with some mild to moderate mental problems who are already on HIV medications and doing well. We will add Maraviroc or a sugar pill to their HIV medications and see if mental function improves over 48 weeks. This study will be conducted at 2 sites in Hawaii and Puerto Rico.

Condition or Disease	Intervention/Treatment	Phase
AIDS Dementia Complex	Drug: Maraviroc Drug: Placebo	Phase 2/Phase 3

Detailed Description

We hypothesize that maraviroc (MVC) will lead to improved cognition as assessed by improvement in neuropsychological (NP) performance. We hypothesize that MVC therapy leads to (1) decrease in HIV infection of monocytes (MO), particularly of CD16-expressing MO and (2) phenotypic and functional secretory changes suggestive of decrease in MO immune activation, and that these changes will lead to less HIV infected activated MO trafficking to the CNS, less CNS inflammation and neuronal damage, and ultimately improved cognition. We will test this in a 48 week trial in 42 HIV infected individuals on suppressive antiretroviral therapy (ART) with mild to moderate cognitive dysfunction. These individuals will be randomized to intensify their ART in double-blind fashion to MVC vs placebo. The primary endpoint will be change in NPZglobal. Magnetic resonance spectroscopy (MRS)/magnetic resonance spectroscopic imaging (MRSI) will be conducted to assess potential alterations in inflammatory and neuronal brain chemicals.

Study Design

Study Type:

Interventional

Actual Enrollment :

48 participants

Allocation:

Randomized

Intervention Model:

Parallel Assignment

Masking:

Triple (Participant, Care Provider, Investigator)

Primary Purpose:

Treatment

Official Title:

Maraviroc and NeuroAIDS Pathogenesis

Actual Study Start Date :

Jun 1, 2015

Actual Primary Completion Date :

Feb 1, 2019

Actual Study Completion Date :

Feb 1, 2019

Arms and Interventions

Arm	Intervention/Treatment
Placebo Comparator: placebo placebo identical in appearance to maraviroc 150 and 300 mg tablets will be added to each subjects antiretroviral regimen at doses as recommended by the package insert	Drug: Placebo Maraviroc placebo administered twice daily, dosage based on concomitant medication being taken.
Experimental: maraviroc Maraviroc Tablets are available as 150 mg and 300 mg tablets. Each subject will add maraviroc to their current antiretroviral regimen with dosage based on recommendations as per maraviroc package insert	Drug: Maraviroc Maraviroc administered twice daily, dosage based on concomitant medication being taken. Other Names: Selzentry

Arm

Intervention/Treatment

Placebo Comparator: placebo

placebo identical in appearance to maraviroc 150 and 300 mg tablets will be added to each subjects antiretroviral regimen at doses as recommended by the package insert

Drug: Placebo

Maraviroc placebo administered twice daily, dosage based on concomitant medication being taken.

Experimental: maraviroc

Maraviroc Tablets are available as 150 mg and 300 mg tablets. Each subject will add maraviroc to their current antiretroviral regimen with dosage based on recommendations as per maraviroc package insert

Drug: Maraviroc

Maraviroc administered twice daily, dosage based on concomitant medication being taken.

Other Names:

Selzentry

Outcome Measures

Primary Outcome Measures

Change in Neuropsychological Performance [48 weeks]
Change in global neuro-psychological Z scores and change in various neuro-psychological Z subdomains will be assessed

Secondary Outcome Measures

Changes in monocyte subsets and function [48 weeks]
Change in monocyte subsets based on CD14 and CD16 expression by flow cytometry; Change in inflammatory and neurotoxic mediators (sCD14, TNFalpha, sCD163 and neopterin
Change in HIV DNA content within MO subsets [48 weeks]
Change in HIV DNA content specifically within each MO subsets
Change in brain metabolites by magnetic resonance spectroscopy [48 weeks]
Change in neuronal and inflammatory brain metabolites globally within brain and in select brain regions

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 70 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Documentation of HIV-1 infection by an FDA approved test at any time prior to study entry.
Receipt of ARV medication uninterrupted for > 1 year leading up to the screening period; brief interruptions for toxicity purposes will be evaluated on a case by case basis and may be allowed
Screening plasma HIV RNA < 50 copies/ml within 3 months of entry
Willingness for both males and females of childbearing potential to utilize 2 effective contraception methods (2 separate forms, one of which must be an effective barrier method), be non-heterosexually active or have a an exclusive vasectomized partner from screening throughout the duration of the study treatment and for 30 days following the last dose of study drugs.
Age between 18 to 70 years.
Ability and willingness to provide written informed consent Mild to moderate cognitive impairment with global neuropsychological (NP) test (NPZglobal) score of < -0.5 OR a neurocognitive abnormality (< -0.5) in at least one cognitive domain known to be typically affected by HIV

Exclusion Criteria:

Currently receiving or having used a CCR5 antagonist as part of an antiretroviral regimen within 6 months of study entry
Plasma HIV RNA > 100 copies/ml at any time within 6 months of study entry
History of HIV-2
Diagnosis of cirrhosis
Active or inadequately treated tuberculosis (TB) infection, or inadequate treatment for a positive purified protein derivative (PPD) test. Adequate treatment is defined as meeting the current recommendations of the Centers of Disease Control and Prevention (CDC), National Institutes of Health (NIH) and the HIV Medicine Association of the Infectious Diseases Society of America (IDSA) guidelines33 or other CDC recommendations if the patient was treated before the current recommendations or before coinfection with HIV.
Uncontrolled seizure disorder
Current malignancy or history of past malignancies excluding basal cell CA and Kaposi's sarcoma restricted to the skin, unless subject considered cured.
Any immunomodulator, HIV vaccine, any other vaccine, or investigational therapy within 30 days of study entry.
Requirement for acute therapy for any AIDS-defining illness or other serious medical illnesses (in the opinion of the site investigator) within 14 days prior to entry.
Chronic illnesses including hematologic, pulmonary, and autoimmune diseases and endocrinopathies, except for stable controlled diabetes or cardiovascular disease in the view of the investigator and stable testosterone or thyroid medication use
Known hypersensitivity to MVC or its excipients
Anticipated need for specific prescription medications. Unwillingness to stop from eating grapefruit or using St. John's wort.
Chronic use of over-the-counter (OTC) medications unless approved by Study Investigator
Hemoglobin < 9.0; Absolute neutrophil count < 500/μL; Platelet count < 40,000/μL; AST (SGOT) and ALT (SGPT) > 5x ULN; Lipase > 2.0 x ULN
Estimated creatinine clearance < 30 cc/min using Cockcroft and Gault method
Abnormal EKG unless determined by the Investigator to be not clinically significant.
Presence of any condition that would interfere with the absorption, distribution, metabolism, or excretion of the drug
Current illicit substance or alcohol use or abuse which, in the judgment of the Investigator, will interfere with the patient's ability to comply with the protocol requirements
Pregnancy or breast-feeding, intent to become pregnant during the study
Patients, who, in the opinion of the Investigator, are unable to comply with the dosing schedule and protocol evaluation or for whom the study may not be advisable
Any factor that precludes MRI scan including presence of metal or exposure to metal work (e.g. metal grinder/worker) and claustrophobia
Any CNS pathology which, in the judgment of the investigator, will interfere with the ability to assess study change in MRSI
Learning disability, history of head injury with prolonged loss of consciousness or cognitive sequelae, history of opportunistic infection of the brain or other non-HIV etiologies that, in the judgment of the investigator, can explain the subjects's mild to moderate cognitive performance.
Serum B12 or folate below the lower limits of normal
Abnormal TSH, except when free T4 is within normal limits
History of untreated or inadequately treated positive RPR

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Clint Spencer Clinic, Hawaii Center for AIDS, University of Hawaii	Honolulu	Hawaii	United States	96813
2	Puerto Rico Clinical and Translational Research Consortium	San Juan		Puerto Rico	00936