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proto nage: Airway Dysfunction and Remodelling in Athletes Following Swimming Training in Chlorinated Pools

Sponsor
Laval University (Other)
Overall Status
Unknown status
CT.gov ID
NCT00686452
Collaborator
(none)
100
Enrollment
1
Location
26
Duration (Months)
3.8
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Swimmers show the highest prevalence of asthma among elite athletes, certainly due to chlorine exposure. The consequences of a chronic exposure to chlorine compounds by swimmers and the mechanisms of asthme in this population are still poorly documented. Specific diagnostic criteria have been proposed by the International Olympic Committee - Medical Council (IOC-MC) and World anti-doping agency (WADA) to determine the presence of asthma in athletes. Using the more specific bronchial provocation tests, our aims are

  1. to compare the prevalence of asthma in swimmers and control subjects

  2. to analyze the Influence of chlorine exposure on bronchial inflammatory processes in swimmers versus control subjects

  3. to study the time-course of changes in airway symptoms, responsiveness, inflammation and remodeling after cessation of training

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Anticipated Enrollment :
    100 participants
    Observational Model:
    Case-Control
    Time Perspective:
    Prospective
    Official Title:
    Airway Dysfunction and Remodelling in Athletes Following Swimming Training in Chlorinated Pools
    Study Start Date :
    Mar 1, 2007
    Anticipated Primary Completion Date :
    May 1, 2009
    Anticipated Study Completion Date :
    May 1, 2009

    Arms and Interventions

    Arm Intervention/Treatment
    1

    Swimmers without AHR
    2

    Swimmers with asymptomatic AHR
    3

    Swimmers with symptomatic AHR and use only of beta-2 adrenargic
    4

    Swimmers with asthma and inhaled corticosteroids
    5

    Healthy Subjects
    6

    Healthy subjects with AHR
    7

    Healthy subjects with symptomatic AHR (asthma) but without treatment

    Outcome Measures

    Primary Outcome Measures

    1. Asthma and airway hyperreactivity prevalence in swimmers [3 measurements in the year]

    Secondary Outcome Measures

    1. Airway inflammation and remodeling in swimmers [3 measurements in the year and a bronchial biopsy]

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    14 Years to 35 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    Yes
    Inclusion Criteria:

    • 14 to 35 years old

    • To swim at least 10h per week

    • For control subjects, non-competitive healthy subjects

    Exclusion Criteria:

    • any disease that may interfere with the tests for the controls

    • Triathletes are excluded

    • Smokers

    • Obese or with a BMI more than 29

    • Former athletes (control group)

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Centre de recherche en pneumologie et en cardiologie de l'hôpital Laval Québec Quebec Canada G1V4G5

    Sponsors and Collaborators

    • Laval University

    Investigators

    None specified.

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    , ,
    ClinicalTrials.gov Identifier:
    NCT00686452
    Other Study ID Numbers:
    • CER20159
    First Posted:
    May 29, 2008
    Last Update Posted:
    Dec 22, 2008
    Last Verified:
    May 1, 2008
    Keywords provided by , ,
    Asthma
    Airway hyperresponsiveness
    Swimmers
    Airway inflammation
    Airway remodelling
    Additional relevant MeSH terms:
    Respiratory Hypersensitivity

    Study Results

    No Results Posted as of Dec 22, 2008