Effects of Chest Wall Elastance on Pulmonary Mechanics of Acute Respiratory Failure (ARF)

Sponsor

Southeast University, China (Other)

Overall Status

Completed

CT.gov ID

NCT02196870

Collaborator

(none)

Enrollment

Location

Duration (Months)

1.1

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Patients with chest wall elastance increasing could worsen lung function. Increasing of chest wall elastance plays a great role in lung mechanics, and could influence mechanical ventilation settings. Therefore, It could help the physicians to find appropriate indicators and optimize the treatments of ARF patients to explore the mechanisms of lung mechanics changse in the patients with high chest wall elastance.

Condition or Disease	Intervention/Treatment	Phase
Airway Pressure Stress Index Transpulmonary Pressure Stress Index Acute Respiratory Failure Chest Wall Elastance

Detailed Description

Mechanical ventilation(MV) is an important treatment for acute respiratory failure(ARF) patients, could improve hypoxemia, maintain lung volume and promote alveolar opening. However, because of barotrauma, volutrauma and biotrauma, MV could cause or aggravate acute lung injury not only in acute respiratory distress syndrome(ARDS) patients, but in patients with normal lung function1,2.

The present study is set out to examine the effects of high chest wall elastance on changes of lung mechanics and the correlation of airway pressure(Paw) stress index and transpulmonary pressure(PL) stress index.

Study Design

Study Type:

Observational [Patient Registry]

Actual Enrollment :

12 participants

Observational Model:

Case-Control

Time Perspective:

Prospective

Official Title:

Physiological Effects of Chest Wall Elastance on Pulmonary Mechanics of Acute Respiratory Failure Patientstranspulmonary Pressure

Study Start Date :

Jul 1, 2014

Actual Primary Completion Date :

Jun 1, 2015

Actual Study Completion Date :

Jun 1, 2015

Outcome Measures

Primary Outcome Measures

Changes of oxygenation and lung mechanics [up to 24 months]

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 85 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

ARF
mechanical ventilation
cardiovascular stable

Exclusion Criteria:

age < 18y or > 85y
pregnancy
COPD or chronic pulmonary disease

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Zhongda Hospital	Nanjing	Jiangsu	China	210009

Sponsors and Collaborators

Southeast University, China

Investigators

Principal Investigator: Jianfeng Xie, Dr., Zhongda hospital, Southeast University, Jiangsu, China

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

Jianfeng Xie, Department of Critical Care Medicine, Zhong-Da Hospital, Southeast University, China

ClinicalTrials.gov Identifier:

NCT02196870

Other Study ID Numbers:

Chest wall Elastance in ARF

First Posted:

Jul 22, 2014

Last Update Posted:

Jun 24, 2015

Last Verified:

Jun 1, 2015

Keywords provided by Jianfeng Xie, Department of Critical Care Medicine, Zhong-Da Hospital, Southeast University, China

Airway pressure stress index

Transpulmonary pressure stress index

Acute Respiratory Failure

Chest wall elastance

Lung stress

Additional relevant MeSH terms:

Respiratory Insufficiency

Respiratory Distress Syndrome

Study Results

No Results Posted as of Jun 24, 2015