ACE1950: Akershus Cardiac Examination (ACE) 1950 Study

Sponsor

Vestre Viken Hospital Trust (Other)

Overall Status

Active, not recruiting

CT.gov ID

NCT01555411

Collaborator

University Hospital, Akershus (Other)

3,706

Enrollment

Locations

459

Anticipated Duration (Months)

1853

Patients Per Site

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Akershus Cardiac Examination (ACE) 1950 Study is a large, observational, prospective, longitudinal, population-based cohort study. The overall aim is to establish an extensive cardio- and cerebrovascular age cohort of elderly subjects for various longitudinal long-term follow-up studies of cardiovascular and cerebrovascular disease.

Condition or Disease	Intervention/Treatment	Phase
Atrial Fibrillation Heart Failure Mild Cognitive Impairment Cardiovascular Diseases Cerebrovascular Disorders

Detailed Description

Design: The Akershus Cardiac Examination (ACE) 1950 Study is a population-based, prospective, cerebro- and cardiovascular age-cohort study of all men and women born in 1950 in Akershus County, Norway.

Time schedule: Study inclusion and baseline examinations took place in the period September 2012 - May 2015. Follow-up and sub-studies are ongoing.

Current status: As per May 2018, follow-up and sub-studies are ongoing.

Study Design

Study Type:

Observational

Anticipated Enrollment :

3706 participants

Observational Model:

Cohort

Time Perspective:

Prospective

Official Title:

Akershus Cardiac Examination 1950 Study - a Cohort Study on Cardio- and Cerebrovascular Disease in 62-65-year-old Subjects

Actual Study Start Date :

Sep 1, 2012

Anticipated Primary Completion Date :

Dec 1, 2050

Anticipated Study Completion Date :

Dec 1, 2050

Arms and Interventions

Arm	Intervention/Treatment
No treatment

Outcome Measures

Primary Outcome Measures

Outcomes related to CVD and CV-associated conditions [Maximum 35 years]

Secondary Outcome Measures

Specific CV endpoints; e.g. acute myocardial infarction, heart failure, atrial fibrillation, etc. [Maximum 35 years]
Specific CV-associated conditions, including renal, cerebrovascular, pulmonary, etc. [Maximum 35 years]
Specific clinical phenotypes; e.g. myocardial and arterial structure and function, lung function, etc. [Maximum 35 years]

Other Outcome Measures

Impact of left atrial size and function measurements by echocardiography on stroke risk in an 62-65-year-old cohort [Within 35 years]
Relation between cognitive function and sub-clinical CVD in a 62-65-year-old Norwegian population cohort [Maximum 35 years]

Eligibility Criteria

Criteria

Ages Eligible for Study:

62 Years to 65 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

Resident in Akershus County (as per October 2011, prior to study invitation)
Born in the year of 1950
Ability to consent to participation

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Akershus University Hospital	Lørenskog	Akershus	Norway	1478
2	Vestre Viken HT, Baerum Hospital, Department of Medical Research	Sandvika	Akershus	Norway	3004

Sponsors and Collaborators

Vestre Viken Hospital Trust
University Hospital, Akershus

Investigators

Study Director: Arnljot Tveit, MD, PhD, Vestre Viken Hospital Trust, Department of Medical Research
Study Director: Helge Røsjø, MD, PhD, University Hospital, Akershus
Principal Investigator: Trygve Berge - member of steering committee, MD, Vestre Viken Hospital Trust, Department of Medical Research
Principal Investigator: Pål Smith - member of steering committee, MD, PhD, University Hospital, Akershus
Principal Investigator: Kjetil Steine - member of steering committee, MD, PhD, University Hospital, Akershus
Principal Investigator: Torbjørn Omland - member of steering committee, MD, PhD, University Hospital, Akershus
Principal Investigator: Magnus N Lyngbakken - member of steering committee, MD, University Hospital, Akershus