Effects of Alcohol History on Effects of Nitrous Oxide - 9

Sponsor

University of Chicago (Other)

Overall Status

Completed

CT.gov ID

NCT00000257

Collaborator

National Institute on Drug Abuse (NIDA) (NIH)

Enrollment

Location

Arms

Duration (Months)

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. Comparisons between nitrous oxide, opiates, and benzodiazepine antagonists will be made. To determine effects of alcohol history on the reinforcing, subjective and psychomotor effects of nitrous oxide in healthy volunteers.

Condition or Disease	Intervention/Treatment	Phase
Alcohol-Related Disorders Opioid-Related Disorders Substance-Related Disorders	Drug: 0% N2O and 10% N2O Drug: 0% N2O and 20% N2O Drug: 0% N2O and 30% N2O Drug: 0% N2O and 40% N2O	N/A

Study Design

Study Type:

Interventional

Actual Enrollment :

19 participants

Allocation:

Non-Randomized

Intervention Model:

Crossover Assignment

Masking:

Double (Participant, Investigator)

Official Title:

Effects of Alcohol History on Effects of Nitrous Oxide

Study Start Date :

Sep 1, 1995

Actual Primary Completion Date :

Apr 1, 1997

Actual Study Completion Date :

Apr 1, 1997

Arms and Interventions

Arm	Intervention/Treatment
Active Comparator: Light drinkers	Drug: 0% N2O and 10% N2O Drug: 0% N2O and 20% N2O Drug: 0% N2O and 30% N2O Drug: 0% N2O and 40% N2O
Active Comparator: Moderate drinkers	Drug: 0% N2O and 10% N2O Drug: 0% N2O and 20% N2O Drug: 0% N2O and 30% N2O Drug: 0% N2O and 40% N2O

Arm

Intervention/Treatment

Active Comparator: Light drinkers

Drug: 0% N2O and 10% N2O

Drug: 0% N2O and 20% N2O

Drug: 0% N2O and 30% N2O

Drug: 0% N2O and 40% N2O

Active Comparator: Moderate drinkers

Drug: 0% N2O and 10% N2O

Drug: 0% N2O and 20% N2O

Drug: 0% N2O and 30% N2O

Drug: 0% N2O and 40% N2O

Outcome Measures

Primary Outcome Measures

Choice of nitrous oxide vs placebo [After 30 min inhalation each of N2O and placebo]
Two subject groups (light drinkers vs moderate drinkers) were asked to inhale a given conc of N2O and inhale a placebo, then choose for a third inhalation. The subject & the technician administering the inhalant were blinded. Testing was done at each dose.