CSDP: Chicago Social Drinking Project
Study Details
Study Description
Brief Summary
This study attempts to elucidate the factors that contribute to escalation and maintenance of excessive ethanol drinking in young adults by:
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Examining subjective and objective response differences to alcohol and other common substances in a sample of young, adult social drinkers with varying consumption patterns.
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Determining whether response to alcohol and other substances is predictive of future consumption patterns through longitudinal follow-up interviews.
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Examining the relationship between responses to alcohol and other substances at baseline and re-examination testing to evaluate if consumption patterns moderate this relationship.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Beverage with Heavy Alcohol Dose Beverage containing 0.8 g/kg alcohol |
Drug: Ethanol
Beverage containing 0.8 g/kg ethanol, 0.4 g/kg ethanol
Other Names:
|
| Experimental: Beverage with Low Alcohol Dose Beverage containing 0.4 g/kg alcohol |
Drug: Ethanol
Beverage containing 0.8 g/kg ethanol, 0.4 g/kg ethanol
Other Names:
|
| Placebo Comparator: Beverage with No alcohol (Placebo) Beverage containing 0.0 g/kg alcohol to act as placebo |
Drug: Placebo
Beverage containing 0.0 g/kg alcohol to act as placebo
|
| Experimental: Beverage with Diphenhydramine Beverage containing 1.5 standard dose of Diphenhydramine (Benadryl) |
Drug: Diphenhydramine
Beverage containing dose equivalent to 1.5 standard doses of Diphenhydramine (Benadryl)
Other Names:
|
| Experimental: Beverage with Caffeine Beverage containing the equivalent of 1.5 times participant's average caffeine consumption |
Drug: Caffeine
Beverage containing the equivalent of 1.5 times the participant's daily caffeine intake
|
Outcome Measures
Primary Outcome Measures
- Subjective response to alcohol and other common substances utilizing mood questionnaires in adult drinkers [Measured during 5 timepoints at each experimental session: 1) Pre-drink baseline, 2) +30 minutes, 3) +60 minutes, 4) +120 minutes, and 5) +180 minutes following the initiation of beverage consumption]
Secondary Outcome Measures
- Substance Use Behavior Reported During Follow-Up Interviews [Measured at 3, 6, 9, 12, 15, 18, 21, 24, 36, 48, and 60 months following the final experimental session]
Eligibility Criteria
Criteria
Inclusion Criteria:
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Age 21-65
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Weigh between 110-210 lbs
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Drink alcohol at least once weekly with weekly "binge" drinking episodes
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Available to complete in-person screening and 2, 4 hour experimental sessions at the University of Chicago
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Available by phone, mail, or Internet for follow-up interviews for at least 2 years following sessions
Exclusion Criteria:
- Current or past major medical or psychiatric disorders including alcohol and substance dependence
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Clinical Addictions Research Laboratory | Chicago | Illinois | United States | 60637 |
Sponsors and Collaborators
- University of Chicago
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Investigators
- Principal Investigator: Andrea C King, PhD, University of Chicago
Study Documents (Full-Text)
None provided.More Information
Publications
- King AC, Byars JA. Alcohol-induced performance impairment in heavy episodic and light social drinkers. J Stud Alcohol. 2004 Jan;65(1):27-36.
- King AC, Houle T, de Wit H, Holdstock L, Schuster A. Biphasic alcohol response differs in heavy versus light drinkers. Alcohol Clin Exp Res. 2002 Jun;26(6):827-35.
- 12119a
- 5R01AA013746