Application of Sticky Bone and Bio-Oss Collagen in Alveolar Ridge Preservation
Study Details
Study Description
Brief Summary
In this experiment, after non-traumatic tooth extraction, the blank group underwent natural healing, and the control group underwent alveolar ridge preservation using Bio-Oss Collagen and the experimental group using Sticky Bone, to verify the application of Bio-Oss Collagen and Sticky Bone in alveolar ridge preservation
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
Within 6 months after tooth extraction, the remaining alveolar ridge undergoes varying degrees of absorption, resulting in a decrease in horizontal width and vertical height of the alveolar ridge. The three-dimensional size change of the alveolar socket may affect the implantation of later implants and cause aesthetic and functional problems. Alveolar ridge preservation can maintain the volume of the alveolar socket, prevent soft tissue from growing into undesirable positions, slow down the absorption of the alveolar ridge to some extent, promote new bone formation, and maintain the shape of the extraction socket. This is crucial for later implant treatment for missing teeth. In this experiment, after non-traumatic tooth extraction, the blank group underwent natural healing, and the control group underwent alveolar ridge preservation using Bio-Oss Collagen and the experimental group using Sticky Bone, respectively, to verify the application of Bio-Oss Collagen and Sticky Bone in alveolar ridge preservation
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| No Intervention: blank group After non-traumatic tooth extraction, the control group will undergo natural healing. |
|
| Active Comparator: control group After non-traumatic tooth extraction, the control group will use alveolar ridge preservation with bio-oss collagen |
Procedure: alveolar ridge preservation with bio-oss collagen
Alveolar ridge preservation with bio-oss collagen is a surgical method that reduces or limits the physiological resorption of alveolar bone after tooth extraction by implanting bio-oss collagen in the socket and covering the biological barrier membrane.
|
| Experimental: experimental group After non-traumatic tooth extraction, the experimental group will use Sticky Bone for alveolar ridge preservation |
Procedure: alveolar ridge preservation with sticky bone
Alveolar ridge preservation with sticky bone is a surgical method that reduces or limits the physiological resorption of alveolar bone after tooth extraction by implanting sticky bone in the socket and covering the biological barrier membrane.
|
Outcome Measures
Primary Outcome Measures
- Changes in horizontal ridge widths [baseline (before the surgery) and six months]
Changes in horizontal ridge widths at 1, 3, and 5 mm below the ridge crest
Secondary Outcome Measures
- Changes in the vertical heights of the ridge [baseline (before the surgery) and six months]
Changes in the vertical heights of the ridge at the buccal and lingual crest areas
- Thicknesses of the keratinized gingiva [baseline (before the surgery) and six months]
Thicknesses of the keratinized gingiva at 2 and 4mm below the highest point of the gingiva
- width of the keratinized gingiva [baseline (before the surgery) and six months]
width of the keratinized gingiva
- percentages of newly formed bone [six months]
percentages of newly formed bone and residual bone substitute material in histologic sections
Eligibility Criteria
Criteria
Inclusion Criteria:
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The presence of one adjacent tooth at the extraction site
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Adequate oral hygiene (plaque index <20%;bleeding on probing <25% )
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Need for tooth extraction due to endodontic，periapical or periodontal disease.
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Presence of ≥ 2 mm of keratinized tissue
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the extraction sockets have no more than 50% of buccal alveolar bone loss(Integrity of alveolar bone walls)
Exclusion Criteria:
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Pregnancy or lactation
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Smoking more than 10 cigarettes per day
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with no evidence of acute infection such as severe swelling, suppuration at the extraction site
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Uncontrolled periodontal disease
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Existence of bone metabolic disease
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history of malignancy, radiotherapy, or chemotherapy in the past 5 years
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Administration of bisphosphonates
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long-term use of NSAIDs
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Alcohol or drug abuse
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Infectious disease, such as hepatitis or human immunodeficiency virus (HIV) and/or acquired immunodeficiency syndrome (AIDS)
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Uncontrolled severe diabetes.( hemoglobin A1c >6.7%)
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | 2nd Affiliated Hospital, School of Medicine, Zhejiang University, China | Hangzhou | Zhejiang | China |
Sponsors and Collaborators
- Second Affiliated Hospital, School of Medicine, Zhejiang University
Investigators
- Study Director: Li Li Zhou, doctor, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, China
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 2023-0369