Acute Exercise on Neurocognitive Function Among Adults With/Without Generic Risk of AD

Sponsor

National Taiwan Normal University (Other)

Overall Status

Completed

CT.gov ID

NCT05591313

Collaborator

(none)

Enrollment

Location

Arms

40.3

Actual Duration (Months)

1.3

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

This study explores the acute exercise effect on neurocognitive function and also its potential moderators in an exercise setting and Apolipoprotein E (APOE) genetic risk.

Condition or Disease	Intervention/Treatment	Phase
Alzheimer Disease 2 Due to Apoe4 Isoform	Behavioral: LI-40 Behavioral: MI-30 Behavioral: HI-16	N/A

Detailed Description

Acute exercise has emerged as a modifier to multiple aspects of cognitive function; however, its effect on populations with different risks of Alzheimer's disease (AD) and the role of exercise variance and APOE genotype within the effect reminds underestimated. The current study aimed to examine the acute exercise effect on neurocognitive function from behavioral and neuroelectric perspectives among cognitively normal late-middle-aged adults. Additionally, we determined whether variations in exercise intensity and duration and the presence of the APOE ɛ4 allele modulated the effect.

Study Design

Study Type:

Interventional

Actual Enrollment :

51 participants

Allocation:

Non-Randomized

Intervention Model:

Factorial Assignment

Intervention Model Description:

The present study adopted a counterbalanced design. All participants were instructed to complete four counterbalanced treatments: a) longer duration (LI-40), b) moderate-intensity with 30 min (MI-30), c) high-intensity with shorter duration (HI-16), and d) control treatments.The present study adopted a counterbalanced design. All participants were instructed to complete four counterbalanced treatments: a) longer duration (LI-40), b) moderate-intensity with 30 min (MI-30), c) high-intensity with shorter duration (HI-16), and d) control treatments.

Masking:

None (Open Label)

Primary Purpose:

Treatment

Official Title:

Acute Exercise Effect on Neurocognitive Function Among Cognitively Normal Late-Middle-Aged Adults With/Without Generic Risk of Alzheimer's Disease: The Moderation Role of Exercise Volume and Apolipoprotein E Genotype

Actual Study Start Date :

May 17, 2016

Actual Primary Completion Date :

Sep 26, 2019

Actual Study Completion Date :

Sep 26, 2019

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Low-intensity with longer duration (40-min) exercise (LI-40) The participants were instructed to complete a volume-matched low-intensity with longer duration (40-min) exercise (LI-40) treatment.	Behavioral: LI-40 Participants were asked to complete a volume-matched light-intensity exercise for 30-min. The exercise volume was pre-determined based on the energy expenditure (kcal) calculated with 5-min warm-up stage, 20-min main exercise stage (i.e., moderate intensity as 50%-60 % heart rate reserve, HRR), and 5-min cool-down stage. Other Names: Light intensity 40-min exercise
Experimental: Moderate-intensity with 30 min exercise (MI-30) The participants were instructed to complete a volume-matched moderate-intensity with 30 min exercise (MI-30) treatment.	Behavioral: MI-30 Participants were asked to complete a volume-matched moderate-intensity exercise for 20-min. The exercise volume was pre-determined based on the energy expenditure (kcal) calculated with 5-min warm-up stage, 20-min main exercise stage (i.e., moderate intensity as 50%-60 % heart rate reserve, HRR), and 5-min cool-down stage. Other Names: Moderate intensity 30-min exercise
Experimental: High-intensity with shorter duration (16-min) exercise (HI-16) The participants were instructed to complete a volume-matched high-intensity with shorter duration (16-min) exercise (HI-16) treatment.	Behavioral: HI-16 Participants were asked to complete a volume-matched high-intensity exercise for 16-min. The exercise volume was pre-determined based on the energy expenditure (kcal) calculated with 5-min warm-up stage, 20-min main exercise stage (i.e., moderate intensity as 50%-60 % heart rate reserve, HRR), and 5-min cool-down stage. Other Names: High intensity 16-min exercise
No Intervention: Control treatment (CON) The participants in the control treatment (CON) were instructed to complete book reading for 30-min.

Outcome Measures

Primary Outcome Measures

Stroop task: Response time [Participants were required to complete the Stroop task approximately 30 min following the cessation of each acute exercise treatment or the 30-min reading.]
A computerized Stroop task was used to assess participants' inhibitory control and basic information processing. The response time of the correct responses was calculated for the first behavioral index.
Stroop task: Accuracy [Participants were required to complete the Stroop task approximately 30 min following the cessation of each acute exercise treatment or the 30-min reading.]
A computerized Stroop task was used to assess participants' inhibitory control and basic information processing. The accuracy was calculated for the second behavioral index.
Event-related potential: P3 amplitude [Participants were required to complete the Stroop task while EEG activity was continuously recorded approximately 30 min following the cessation of each acute exercise treatment or the 30-min reading.]
The event-related potential from parietal electrodes (i.e., P3, Pz, and P4) were initially outputted for the mean P3 amplitude; the averaged mean P3 amplitudes from parietal electrodes was then calculated as the neuroelectrical indices.

Eligibility Criteria

Criteria

Ages Eligible for Study:

50 Years to 70 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

Adults aged between 50 and 70 years old
Normal or corrected-to-normal vision based on the minimal 20/20 standard
Cognitively normal as mini-mental state examination scores (MMSE) > 26

Exclusion Criteria:

Neurological or psychiatric disorders
Cardiovascular disease
Risk of cardiovascular fitness assessment based on the Physical Activity Readiness Questionnaire (PAR-Q)
Red-green color blindness.