REACT: rTMS for Apathy Clinical Trial
Study Details
Study Description
Brief Summary
Apathy is a common, early, and disabling symptom in dementias such as Alzheimer's disease (AD) and is characterized by lack of interest and enthusiasm. Both repetitive transcranial magnetic stimulation (rTMS), a form of non-invasive brain stimulation, and methylphenidate, a medication, have been shown to improve apathy. This pilot study will investigate rTMS as a treatment for apathy in AD in individuals receiving methylphenidate and individuals not receiving medication for apathy.
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
|
N/A |
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Experimental: rTMS + methylphenidate repetitive transcranial magnetic stimulation (rTMS) and methylphenidate |
Device: rTMS
repetitive transcranial magnetic stimulation
Drug: methylphenidate
methylphenidate
|
Experimental: rTMS only repetitive transcranial magnetic stimulation (rTMS) only |
Device: rTMS
repetitive transcranial magnetic stimulation
|
Outcome Measures
Primary Outcome Measures
- Apathy Evaluation Scale [2 weeks]
Measure of apathy on a scale from 18 to 72 with a lower score indicating greater apathy
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Alzheimer's disease or mixed Alzheimer's disease/vascular disease
-
Apathy for at least 4 weeks
-
Stable dose of medication (>4 weeks) that may affect cognition or behaviour
-
Care partner who spends at least 10 hours a week with the subject
Exclusion Criteria:
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Current major depressive episode
-
Agitation, delusions, hallucination
-
Medical contraindications to rTMS
-
Currently taking an amphetamine product
-
Central nervous system abnormalities, Tourette's syndrome, or motor tics
-
Current participation in another clinical trial
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | Sunnybrook Health Sciences Centre | Toronto | Ontario | Canada | M4N 3M5 |
Sponsors and Collaborators
- Sunnybrook Health Sciences Centre
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- SUN-5342