Semantic Recognition Task (SRT) in Alzheimer Disease

• Sponsor: Istanbul University (Other)
• Overall Status: Recruiting
• CT.gov ID: NCT05711888
• Collaborator: (none)
• Enrollment: 80
• Location: 1
• Arm: 1
• Anticipated Duration (Months): 1.2
• Patients Per Site Per Month: 67.6

Study Details

Study Description

Brief Summary

The goal of this study is to observe the outcomes of a semantic recognition task in Alzheimer Disease and discuss what this might add to clinical practice.

Condition or Disease	Intervention/Treatment	Phase
Alzheimer Disease	Behavioral: Semantic Recognition Procedure	N/A

Detailed Description

In classical memory testing procedures, the outcomes of recognition task is related to hippocampal memory deficits knowing that the recognition task is not purely temporal lobe activity. The aim of this study is to propose a recognition task more specific to temporal lobe activity.

Study Design

• Study Type: Interventional
• Anticipated Enrollment: 80 participants
• Allocation: N/A
• Intervention Model: Single Group Assignment
• Intervention Model Description: Semantic recognition task outcomes are observed in people diagnosed with Alzheimer's disease with Non-Alzheimer population.Semantic recognition task outcomes are observed in people diagnosed with Alzheimer's disease with Non-Alzheimer population.
• Masking: None (Open Label)
• Primary Purpose: Diagnostic
• Official Title: A Sensitive Measurement Proposal in Alzheimer's Disease: Semantic Recognition Task
• Actual Study Start Date: Dec 21, 2022
• Actual Primary Completion Date: Jan 20, 2023
• Anticipated Study Completion Date: Jan 26, 2023

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Semantic information in Alzheimer Disease To observe the semantic information processing in early stages of Alzheimer Disease is the main aim of the study. A paper-pencil neuropsychological assessment battery will be used. For memory testing FCSRT (free and cued selective reminding test) will be used. The patients are going to be assessed while in clinical diagnosis routine.	Behavioral: Semantic Recognition Procedure; A semantic recognition task is going to be added to administrated FCSRT procedure after immediate and delayed recall phases.

Outcome Measures

Primary Outcome Measures

1. Semantic Recognition Task [1 day]

   The number of correct answers will be observed just after the short-term learning procedure and just after the delayed recall procedure among people with positive biomarker compared to those with negative biomarker to Alzheimer Disease.

Eligibility Criteria

Criteria

• Ages Eligible for Study: N/A and Older
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: Yes

Inclusion Criteria:

• to have biomarker analysis for Alzheimer disease (positive or negative).

Exclusion Criteria:

• illiteracy

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Jbid Dursun Uncu	Beşiktaş	İstanbul	Turkey	34340

Sponsors and Collaborators

• Istanbul University

Investigators

• Study Director: İ. Hakan Gürvit, Prof. MD., Istanbul University

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: Jbid DURSUN UNCU, PhD Student, Istanbul University
• ClinicalTrials.gov Identifier: NCT05711888
• Other Study ID Numbers: E-29624016-050.99-1484553
• First Posted: Feb 3, 2023
• Last Update Posted: Feb 3, 2023
• Last Verified: Jan 1, 2023

• Individual Participant Data (IPD) Sharing Statement: No
• Plan to Share IPD: No
• Studies a U.S. FDA-regulated Drug Product: No
• Studies a U.S. FDA-regulated Device Product: No
• Keywords provided by Jbid DURSUN UNCU, PhD Student, Istanbul University: Alzheimer Disease; Recognition; Semantic; Memory; Free and Cued Selective Reminding Test
• Additional relevant MeSH terms: Alzheimer Disease

Study Results

No Results Posted as of Feb 3, 2023