FIND-AD: Financial Incentives and Recruitment to the APT Webstudy

Sponsor

University of Southern California (Other)

Overall Status

Not yet recruiting

CT.gov ID

NCT06033066

Collaborator

American Heart Association (Other), Schaeffer Center for Health Policy & Economics (Other), Alzheimer's Therapeutic Research Institute (Other)

48,000

Enrollment

Arms

Anticipated Duration (Months)

Study Details

Study Description

Brief Summary

This single-blind, three-arm, randomized, controlled trial will assess the impact of messages and financial incentives on the enrollment of demographically diverse individuals to the Alzheimer Prevention Trials (APT) Webstudy. The APT Webstudy is a novel, online registry that employs quarterly cognitive testing using validated platforms. The APT Webstudy implements fully remote assessments, coordinated by the Alzheimer's Therapeutic Research Institute (ATRI) under USC IRB #HS-17-00746. The purpose of the current study is to test whether we can increase enrollment of diverse individuals into the registry. To do this, we will work with Contra Costa Regional Medical Center (CCRMC), the county public hospital and its affiliated health centers in Contra Costa County, California, to test whether sending messages with and without financial incentives to patients who receive primary care with the health system can increase enrollment to the APT Webstudy. The investigators hypothesize that 1) a certain small financial incentive and an award opportunity based incentive (or a drawing with a prize) will increase enrollment rates of CCHS members into the APT Webstudy relative to the control group. The investigators further hypothesize that the award opportunity incentive will increase the enrollment rate of CCRMC patients into the APT Webstudy more than a certain financial incentive with the same expected value.

Condition or Disease	Intervention/Treatment	Phase
Alzheimer Disease Dementia Preclinical Alzheimer's Disease Prodromal Alzheimer's Disease	Behavioral: Financial Incentives Behavioral: Message	N/A

Study Design

Study Type:

Interventional

Anticipated Enrollment :

48000 participants

Allocation:

Randomized

Intervention Model:

Parallel Assignment

Masking:

None (Open Label)

Primary Purpose:

Health Services Research

Official Title:

A Randomized Trial of Financial Incentives for the Recruitment of County Health System Patients to the Alzheimer Prevention Trials (APT) Webstudy

Anticipated Study Start Date :

Sep 1, 2023

Anticipated Primary Completion Date :

Mar 1, 2026

Anticipated Study Completion Date :

Mar 1, 2026

Arms and Interventions

Arm	Intervention/Treatment
Active Comparator: Messaging Only 16,000 participants will be randomized to Arm 1 where no monetary incentive is offered.	Behavioral: Message Message inviting participant to enroll
Experimental: Small Incentive 16,000 participants will be randomized to Arm 2 where a small one-time monetary incentive is offered.	Behavioral: Financial Incentives Small financial incentive or prize incentive
Experimental: Prize Incentive 16,000 participants will be randomized to Arm 3 where an opportunity based incentive (or a drawing with a prize) with a single winner will be offered.	Behavioral: Financial Incentives Small financial incentive or prize incentive

Arm

Intervention/Treatment

Active Comparator: Messaging Only

16,000 participants will be randomized to Arm 1 where no monetary incentive is offered.

Behavioral: Message

Message inviting participant to enroll

Experimental: Small Incentive

16,000 participants will be randomized to Arm 2 where a small one-time monetary incentive is offered.

Behavioral: Financial Incentives

Small financial incentive or prize incentive

Experimental: Prize Incentive

16,000 participants will be randomized to Arm 3 where an opportunity based incentive (or a drawing with a prize) with a single winner will be offered.

Behavioral: Financial Incentives

Small financial incentive or prize incentive

Outcome Measures

Primary Outcome Measures

Enrollment status into the APT Webstudy [2-weeks]
APT Webstudy enrollment rate based on completion of at least one of the two APT Webstudy cognitive assessments (Cognitive Function Instrument [CFI] and/or Cogstate Brief Battery).

Secondary Outcome Measures

Cost per enrollee [annual]
Cost to acquire an enrollment
Completion of cognitive assessments within the APT Webstudy [2-weeks]
Completion of both APT Webstudy cognitive assessments (Cognitive Function Instrument [CFI] and/or Cogstate Brief Battery).

Eligibility Criteria

Criteria

Ages Eligible for Study:

50 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

To be eligible to participate in this study, an individual must meet all of the following criteria:

Patients empaneled at Contra Costa Regional Medical Center (CCRMC), the county public hospital and its affiliated health centers.
Age 50 or older
Literate in either English or Spanish