Alzheimer's Disease Prevention Trial

Sponsor

National Institute on Aging (NIA) (NIH)

Overall Status

Completed

CT.gov ID

NCT00000176

Collaborator

(none)

Locations

Study Details

Study Description

Brief Summary

This is a three-year study to determine if estrogens can prevent memory loss and Alzheimer's disease in women with a family history of Alzheimer's disease.

Condition or Disease	Intervention/Treatment	Phase
Alzheimer Disease Memory Disorders	Drug: Estrogen Drug: Estrogen and Progesterone	Phase 3

Detailed Description

PREventing Postmenopausal memory loss and Alzheimer's with Replacement Estrogens (PREPARE) is a double-blind-placebo controlled trial to determine whether estrogen (or estrogen and progesterone) can delay the onset of memory loss or Alzheimer's Disease in elderly women with a family history of the disease.

Study Design

Study Type:

Interventional

Allocation:

Randomized

Masking:

Double

Primary Purpose:

Prevention

Official Title:

Alzheimer's Disease Prevention Trial. A Multi-center, Randomized, Double-blind Placebo Controlled Trial of Estrogens to Prevent Alzheimer's Disease and Loss of Memory in Women.

Actual Primary Completion Date :

Sep 1, 2007

Actual Study Completion Date :

Sep 1, 2007

Outcome Measures

Primary Outcome Measures

Eligibility Criteria

Criteria

Ages Eligible for Study:

65 Years and Older

Sexes Eligible for Study:

Female

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

Healthy women 65 or older with a family history of memory problems not currently on estrogen.

Exclusion Criteria:

Significant neurological impairment
Current estrogen use
History of breast cancer

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	University of Alabama	Birmingham	Alabama	United States	35294
2	University of California, Irvine	Irvine	California	United States	29697-4540
3	New England Center for Headache	Stamford	Connecticut	United States	06902-1249
4	Howard University	Washington	District of Columbia	United States	20060
5	Lee Memorial Health System	Fort Myers	Florida	United States	33901
6	Mayo Clinic Jacksonville	Jacksonville	Florida	United States	32225
7	Wein Center	Miami Beach	Florida	United States	33140
8	West Florida Regional Medical Center	Pensacola	Florida	United States	32514
9	North Broward Medical Center	Pompano Beach	Florida	United States
10	Tallahassee Memorial Health Center	Tallahassee	Florida	United States	32308
11	St. Mary's Medical Center	West Palm Beach	Florida	United States	33407
12	Johns Hopkins Bayview Medical Center	Baltimore	Maryland	United States	21224
13	Neurology Group of Bergen County	Ridgewood	New Jersey	United States	07450
14	Columbia University	New York	New York	United States	10032
15	Cornell Medical Center, New York Presbyterian Medical Center	New York	New York	United States
16	New York United Hospital Medical Center	Port Chester	New York	United States	10573
17	Burke Medical Research Institute	White Plains	New York	United States	10605
18	Duke University Medical Center	Durham	North Carolina	United States	27710
19	Clinical Pharmaceutical Trials	Tulsa	Oklahoma	United States	74104-5428
20	Butler Hospital, Rhode Island Hospital	Providence	Rhode Island	United States	02906
21	Medical University of South Carolina	North Charleston	South Carolina	United States	29406
22	Eastern Virginia Medical School	Norfolk	Virginia	United States	23507-1912