Cognitive-motor Intervention Using Virtual Reality for Middle-aged Individuals at High Dementia Risk
Study Details
Study Description
Brief Summary
The primary objective of this program is to apply a virtual reality (VR) cognitive-motor intervention (compared to active and passive control groups) to delay or slow cognitive decline of middle-aged adults who have a family history of Alzheimer's disease (AD) and thus are at particularly high risk of developing the disease.
Condition or Disease | Intervention/Treatment | Phase |
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N/A |
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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Experimental: VR cognitive tasks + treadmill This is the primary group of interest, in which the investigators hypothesize the greatest cognitive gains since motor activity will augment cognitive activity. |
Behavioral: cognitive training by virtual reality
Device: treadmill
VR cognitive training will be augmented by walking on a treadmill, since it is well established that dual tasking-i.e. performing the VR-based cognitive effort together with a motor task, even as simple as walking on a treadmill-places greater demand on cognitive resources than a "single task".
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Active Comparator: VR cognitive tasks - treadmill This group will be an active control, receiving the VR cognitive training without treadmill walking, to examine whether the motor component augments the effect of the VR in the experimental group. |
Behavioral: cognitive training by virtual reality
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Sham Comparator: scientific TV documentary + treadmill This group will watch a scientific TV documentary while walking on the treadmill. This control group will permit examination of whether the VR cognitive training, which requires an especially active cognitive effort while walking on the treadmill, is more advantageous than passively watching a scientific TV documentary while performing the same motor task as the experimental group. |
Behavioral: watching a scientific TV documentary
Device: treadmill
VR cognitive training will be augmented by walking on a treadmill, since it is well established that dual tasking-i.e. performing the VR-based cognitive effort together with a motor task, even as simple as walking on a treadmill-places greater demand on cognitive resources than a "single task".
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No Intervention: Passive control This group of participants will not receive any intervention but will be assessed with the same battery of assessments as the other three groups, permitting comparisons of the cognitive and neurobiological outcomes of the intervention groups to that of the natural course of decline/deterioration of these at-risk individuals. |
Outcome Measures
Primary Outcome Measures
- change in overall cognition- measured by averaging z-scores from 14 paper and pencil neuropsychological tests covering episodic memory and executive functions cognitive domains. [baseline, immediately after 12-week training, and 3 months post-training (or corresponding time points in passive control group)]
summary of the z-scores of all 14 paper and pencil cognitive tests
- change in cerebral blood flow from arterial spin labeling (ASL) [baseline, immediately after 12-week training, and 3 months post-training (or corresponding time points in passive control group)]
acquired by structural MRI using background-suppressed pseudo-continuous ASL (pcASL) featuring a 3D fast spin echo spiral sequence
Secondary Outcome Measures
- specific cognitive domains- average of z-scores of paper and pencil memory tests and of executive functions tests [baseline, immediately after 12-week training, and 3 months post-training (or corresponding time points in passive control group)]
summary of z-scores of executive functions tests and of episodic memory tests
- blood oxygenation level dependent (BOLD) functional MRI (fMRI) signal in the fronto-parietal network associated with working memory [baseline, immediately after 12-week training, and 3 months post-training (or corresponding time points in passive control group)]
T2*-weighted fMRI during an n-back working memory task; contrasts: 1-back minus 0-back; 2-back minus 0-back; 2-back minus 1-back
- brain resting state functional connectivity by resting state network fMRI BOLD signal correlations [baseline, immediately after 12-week training, and 3 months post-training (or corresponding time points in passive control group)]
T2*-weighted fMRI while relaxing with eyes closed; functional connectivity between seed regions of resting state networks (e.g., default mode, attentional, salience) and other regions by correlation of BOLD signal in seed regions with that in other regions
- hippocampal volume [baseline, immediately after 12-week training, and 3 months post-training (or corresponding time points in passive control group)]
3D T1-weighted MRI imaging
- frontal inferior cortex volume [baseline, immediately after 12-week training, and 3 months post-training (or corresponding time points in passive control group)]
3D T1-weighted MRI imaging
- white matter hyperintensity (WMH) burden [baseline, immediately after 12-week training, and 3 months post-training (or corresponding time points in passive control group)]
3D T2-FLAIR MRI imaging
- diffusion-tensor imaging (DTI) measures [baseline, immediately after 12-week training, and 3 months post-training (or corresponding time points in passive control group)]
diffusion-weighted MRI imaging (DWI) to map white matter tractography
Eligibility Criteria
Criteria
Inclusion Criteria:
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The participants of the study must have at least one parent with Alzheimer's disease.
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Fluency in Hebrew, in order to understand the instructions of the cognitive tests.
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Availability of an informant for the participant.
Exclusion Criteria:
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Severe neurological or psychological conditions that may affect cognitive performance.
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Substantial orthopedic limitations which prevent the use of treadmill.
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Unstable medical condition such as an active cancer.
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Incapability of adherence to the training program.
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The participant is undergoing a treatment that may interfere with the study program.
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | Sheba Medical Center | Ramat Gan | Israel |
Sponsors and Collaborators
- Sheba Medical Center
Investigators
- Principal Investigator: Michal Schnaider Beeri, PhD, Sheba Medical Center/Icahn School of Medicine at Mount Sinai
Study Documents (Full-Text)
None provided.More Information
Publications
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- Optale G, Urgesi C, Busato V, Marin S, Piron L, Priftis K, Gamberini L, Capodieci S, Bordin A. Controlling memory impairment in elderly adults using virtual reality memory training: a randomized controlled pilot study. Neurorehabil Neural Repair. 2010 May;24(4):348-57. doi: 10.1177/1545968309353328. Epub 2009 Nov 24.
- Rebok GW, Ball K, Guey LT, Jones RN, Kim HY, King JW, Marsiske M, Morris JN, Tennstedt SL, Unverzagt FW, Willis SL; ACTIVE Study Group. Ten-year effects of the advanced cognitive training for independent and vital elderly cognitive training trial on cognition and everyday functioning in older adults. J Am Geriatr Soc. 2014 Jan;62(1):16-24. doi: 10.1111/jgs.12607. Epub 2014 Jan 13.
- Stern Y. Cognitive reserve in ageing and Alzheimer's disease. Lancet Neurol. 2012 Nov;11(11):1006-12. doi: 10.1016/S1474-4422(12)70191-6. Review.
- Tárraga L, Boada M, Modinos G, Espinosa A, Diego S, Morera A, Guitart M, Balcells J, López OL, Becker JT. A randomised pilot study to assess the efficacy of an interactive, multimedia tool of cognitive stimulation in Alzheimer's disease. J Neurol Neurosurg Psychiatry. 2006 Oct;77(10):1116-21. Epub 2006 Jul 4.
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- SHEBA-16-2988-MSB-CTIL