NCRAD: Alzheimer's Disease Genetics Study

Sponsor

Indiana University (Other)

Overall Status

Recruiting

CT.gov ID

NCT00064870

Collaborator

National Institute on Aging (NIA) (NIH)

3,000

Enrollment

Location

289

Duration (Months)

10.4

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The purpose of the Alzheimer's Disease Genetics Study is to identify the genes that are responsible for causing Alzheimer's Disease (AD). One of the ways in which the risk factor genes for late onset AD can be investigated is by identifying and collecting genetic material from families with multiple members diagnosed with AD or dementia.

Condition or Disease	Intervention/Treatment	Phase
Alzheimer Disease Late Onset Alzheimer Disease Dementia

Detailed Description

The purpose of the Alzheimer's Disease Genetics Study is to help identify the genes that may be responsible for causing Alzheimer's Disease (AD) by collecting genetic material from families with multiple members diagnosed with AD. Qualifying families will have two living blood-related individuals who have been diagnosed with or are showing symptoms of AD or dementia. Local study sites are located all over the United States, and arrangements may be made for eligible families who do not live near a participating site. The biological samples and data from these families will be made available to qualified researchers, who must sign a Materials Transfer Agreement (MTA) in order to protect the privacy rights of study participants before receiving samples and data.

Study Design

Study Type:

Observational

Anticipated Enrollment :

3000 participants

Observational Model:

Cohort

Time Perspective:

Prospective

Official Title:

National Cell Repository for Alzheimer's Disease (NCRAD)

Study Start Date :

Jun 1, 2002

Anticipated Primary Completion Date :

Jul 1, 2026

Anticipated Study Completion Date :

Jul 1, 2026

Outcome Measures

Primary Outcome Measures

Distribute biological specimens to qualified investigators for use in their research studies. [Contact investigators annually for an update on progress and publication status.]
Investigators will analyze the samples and publish de-identified results. These publications will help to further the knowledge in the field of dementia and potentially lead to new therapies and targets for therapies.

Eligibility Criteria

Criteria

Ages Eligible for Study:

N/A and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

Two living family members diagnosed with AD or other dementia with any age of onset
Biological samples available
Fresh blood, or
Immortalized lymphoblastic cell lines, or
3-5 grams of frozen cerebral cortex; fixed samples are not accepted

Please note: this study does not include genetic counseling; because no personal identifying information such as name or date of birth is attached to samples, results of individual tests are not available to participants or family members.

Exclusion Criteria:

Does not meet inclusion criteria
Member of a family that was included in the National Institute of Mental Health AD Genetics Sib Pair collection

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Participants are being recruited from all over the United States	Multiple Locations	Indiana	United States	46202

Sponsors and Collaborators

Indiana University
National Institute on Aging (NIA)

Investigators

Principal Investigator: Tatiana M. Foroud, PhD, National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD), Indiana University