A Comparative Study Between Dissociative Treatment and Binocular Interactive Treatment in Amblyopia

Sponsor

Ain Shams University (Other)

Overall Status

Unknown status

CT.gov ID

NCT03255707

Collaborator

(none)

100

Enrollment

Location

Arms

Anticipated Duration (Months)

2.1

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Amblyopia is a unilateral or, infrequently, a bilateral reduction of best corrected visual acuity which cannot be attributed to coexisting eye or visual pathway disease. Amblyopia can be due to eye-crossing occurring in early childhood or due to error of refraction whether a high difference between the two eyes or very high bilateral refractive errors.Another cause could be visual deprivation like the presence of congenital cataract.

The prevalence of amblyopia worldwide is approximately 1%-5% .In Egypt, a study that was held in Upper Egypt, found that the prevalence of amblyopia was 1.49%, which is higher in rural areas than in urban areas.

Several modalities of treatment for amblyopia are available, yet occlusion treatment is the gold standard involving covering the good eye with a patch for a prescribed period of time ranging from 10 minutes daily to all waking hours. However, its effectiveness decreases in older children and adults.

Disadvantages include prolonged treatment leading to poor compliance, patching related distress, relationship strain and stigma. In extreme cases, non-compliance with patching results in a costly hospital admission to supervise the patching treatment. In addition, wearing a patch eliminates any advantage of binocularity. Not to mention that not all patients respond to patching and of those who do, many have residual amblyopia after treatment is stopped regardless of compliance. More importantly, binocular vision is not automatically restored once the vision in the amblyopic eye has been improved. In fact, once the patch is removed after therapy, the amblyopic eye could be suppressed by the better seeing eye and can lose some of the gains achieved as a result of therapy.

Another modality of treatment is atropine eye drops and optical penalisation which are usually secondary treatments to failed patching but carrying the same disadvantages as the ordinary patching.

Advances in amblyopia treatment include dichoptic training, perceptual learning, and video gaming. These depend on the fact that the adult brain has been shown to be much more plastic than it was once believed to be and hence have the advantage of expanding the age of response in adults.

Perceptual learning approaches have the advantage of being a dichoptic (binocular treatment using both eyes) approach which is independent of age and type of amblyopia.

A step further to conventional treatment is the use of a home-based approach allowing remote internet monitoring of treatment between office visits and hence better compliance. In addition a video game version of the treatment is developed to make it more enjoyable for improving compliance.

Our goal is to compare the outcome between the gold standard occlusion therapy and one of the dichoptic treatments.

Condition or Disease	Intervention/Treatment	Phase
Amblyopia	Device: eye patch Device: dichoptic treatment	N/A

Detailed Description

Introduction Amblyopia is a unilateral or, infrequently, a bilateral reduction of best corrected visual acuity which cannot be attributed to coexisting eye or visual pathway disease. Amblyopic eyes may have decreased contrast sensitivity and accommodation deficit. The fellow eye is not often normal but has subtle deficits.This can be explained by interocular suppression, or inhibition of the amblyopic eye by the strong eye, with psychophysical and physiological evidence.

Amblyopia can be classified as follows: 1) Strabismic occurring in early childhood 2) Refractive: a) Anisometropic b) High bilateral refractive errors 3) Visual deprivation.

The prevalence of amblyopia worldwide is approximately 1%-5%. In Egypt, a study that was held in Upper Egypt, found that the prevalence of amblyopia was 1.49%, which is higher in rural areas than in urban areas.

Another modality of treatment is atropine eye drops and optical penalisation which are usually secondary treatments to failed patching but carrying the same disadvantages as the ordinary patching.

Perceptual learning approaches have the advantage of being a dichoptic (binocular treatment) approach which is independent of age and type of amblyopia. Furthermore, it has been shown recently that therapy promotes binocular vision by strengthening stereopsis and reducing suppression.

Aim of the work:

To compare the gold standard occlusion therapy alone with dichoptic therapy

Patients and Methods:

Design:

The study will be a prospective experimental controlled study.

Patients of the study:

From the vicinity of the ophthalmology outpatient clinic of Ain Shams University Hospital, 100 patients of both sexes with amblyopia will be enrolled to this study. Informed consents will be obtained from adult patients and children's parents.

Patients will be assigned randomly into two groups:

Group A: 50 patients will receive the gold standard occlusion therapy

Group B: 50 patients will receive dichoptic treatment in the form of playing a video game (Lazy Eye Blocks ®) while wearing a red/green goggle.

Each group will be subdivided according to age:

From 4 to 7 years.
From above 7 to 12 years.
From above 12 to 30 years.

Hours of occlusion will be classified according to the degree of amblyopia:

Mild to moderate amblyopia (Best corrected visual acuity (BCVA)< 0.2): 2-4 hours occlusion
Severe (BCVA> 0.2): 4-6 hours occlusion

Hours of dichoptic treatment in group B will be classified according to the degree of amblyopia:

Mild to moderate amblyopia (BCVA< 0.2): 2-4 hours of treatment
Severe (BCVA> 0.2): 4-6 hours of treatment

Methods

All patients will undergo the following:

Full medical and ophthalmic history
Examination:

A) External Appearance:

Anomalous Head Position, globes (e.g., proptosis), lids (e.g. ptosis).

B) Refraction:

With and without cyclopegia

C) Visual acuity:

With and without correction using Snellen acuity chart and preferential looking test for non-verbal patients.

D) Motility:

Ductions and versions (9 positions of gaze) E) Angle of deviation if any

F) Fixation :

Fixation behavior (fixation preference) will be tested via base down 10 prism diopter fixation preference test.

Quantitative Binocular vision assessment H) Anterior segment examination. I) Posterior segment examination using indirect ophthalmoscopy with a 20 diopter lens through a dilated pupil.

All patients in Group A will receive the gold standard occlusion therapy. All patients in Group B will receive dichoptic treatment

Study Design

Study Type:

Interventional

Anticipated Enrollment :

100 participants

Allocation:

Randomized

Intervention Model:

Parallel Assignment

Intervention Model Description:

Patients of the study will be recruited from the ophthalmology outpatient clinic of Ain Shams University Hospital.100 patients of both sexes with amblyopia will be enrolled. Informed consents will be obtained from adult patients and children's parents. Patients will be assigned randomly: Group A:50 patients will receive the gold standard occlusion therapy while playing a video game (Lazy Eye Tetris games such as Lazy Eye Blocks ®).Group B:50 patients will receive dichoptic treatment in the form of playing a video game (Lazy Eye Tetris games such as Lazy Eye Blocks ®) while wearing a red/green goggle.Each group will be subdivided according to age: 1)4 to 7 years. 2)>7 to 12 years. 3)>12 to 30 years. Hours of occlusion /dichoptic treatment will be classified according to the degree of amblyopia: Mild to moderate amblyopia (Best corrected visual acuity (BCVA)< 0.2) : 2-4 hours Severe (BCVA> 0.2) : 4-6 hours All patients will undergo full ophthalmological examinationPatients of the study will be recruited from the ophthalmology outpatient clinic of Ain Shams University Hospital.100 patients of both sexes with amblyopia will be enrolled. Informed consents will be obtained from adult patients and children's parents.Patients will be assigned randomly:Group A:50 patients will receive the gold standard occlusion therapy while playing a video game (Lazy Eye Tetris games such as Lazy Eye Blocks ®).Group B:50 patients will receive dichoptic treatment in the form of playing a video game (Lazy Eye Tetris games such as Lazy Eye Blocks ®) while wearing a red/green goggle.Each group will be subdivided according to age:1)4 to 7 years. 2)>7 to 12 years. 3)>12 to 30 years.Hours of occlusion /dichoptic treatment will be classified according to the degree of amblyopia:Mild to moderate amblyopia (Best corrected visual acuity (BCVA)< 0.2) : 2-4 hours Severe (BCVA> 0.2) : 4-6 hours All patients will undergo full ophthalmological examination

Masking:

None (Open Label)

Primary Purpose:

Treatment

Official Title:

A Comparative Study Between Dissociative Treatment and Binocular Interactive Treatment in Amblyopia

Actual Study Start Date :

Nov 24, 2016

Anticipated Primary Completion Date :

Nov 24, 2017

Anticipated Study Completion Date :

Nov 24, 2020

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Group A 50 patients will receive the gold standard occlusion therapy	Device: eye patch Occluding the better seeing eye for a given number of hours daily
Experimental: Group B 50 patients will receive dichoptic treatment in the form of playing a video game (Lazy Eye Blocks ®) while wearing a red/green goggle.	Device: dichoptic treatment dichoptic treatment in the form of playing a video game (Lazy Eye Blocks ®) while wearing a red/green goggle.

Arm

Intervention/Treatment

Experimental: Group A

50 patients will receive the gold standard occlusion therapy

Device: eye patch

Occluding the better seeing eye for a given number of hours daily

Experimental: Group B

50 patients will receive dichoptic treatment in the form of playing a video game (Lazy Eye Blocks ®) while wearing a red/green goggle.

Device: dichoptic treatment

dichoptic treatment in the form of playing a video game (Lazy Eye Blocks ®) while wearing a red/green goggle.

Outcome Measures

Primary Outcome Measures

visual acuity [6 months]
Best corrected visual acuity in the amblyopic eye

Secondary Outcome Measures

Compliance [6 months]
Compliance of the patient to treatment
crowding ratio [6 months]
crowded vs uncrowded visual acuity

Eligibility Criteria

Criteria

Ages Eligible for Study:

4 Years to 30 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

Any degree of amblyopia
Orthotropia in primary position.

Exclusion Criteria:

Any ocular disease affecting vision
Angle of deviation in primary position (Heterotropia)
Adult patients and children's parents unwilling to enter or complete the study
Ignorance of patients to use the video game

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Ain Shams University Hospitals (Demerdash)	Cairo		Egypt

Sponsors and Collaborators

Ain Shams University

Investigators

Study Chair: Hazem H Nouh, MD, Ophthalmology department, faculty of medicine, Ain Shams University
Study Chair: Mohammad A Rashad, MD, Ophthalmology department, faculty of medicine, Ain Shams University
Study Director: Walid M El-Zawahry, MD, Ophthalmology department, faculty of medicine, Ain Shams University
Study Director: Ahmad T Ismail, MD, Ophthalmology department, faculty of medicine, Ain Shams University
Principal Investigator: Suha A Hussein, M.Sc, Ophthalmology department, faculty of medicine, Ain Shams University