AMS Study: Inflammatory and Biomechanical Contributors to Arthritis Development Following Arthroscopic Meniscectomy
Study Details
Study Description
Brief Summary
The purpose of this study is to examine the relationship between muscle activation and heart rate on joint generalized inflammation and arthritis development.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Detailed Description
This study will test the hypothesis that knee trauma (as exemplified by the arthroscopy procedure) causes inflammation that alters muscle activation patterns locally and also disrupts the balance between parasympathetic-sympathetic reflexes. It is hypothesized that these factors contribute to development and progression of knee osteoarthritis.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| 1 24 adults with meniscal damage for which arthroscopy is clinically indicated |
|
| 2 8 adults who have already undergone meniscal resection to serve as positive controls |
Outcome Measures
Primary Outcome Measures
Eligibility Criteria
Criteria
Inclusion Criteria:
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Age 40 or older
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Potential candidate for knee arthroscopy for medial
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Meniscal tear confirmed on MRI
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Prior meniscal resection at least 1 year prior with a persistent knee effusion
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Body mass index between 25-35 kg/m2
Exclusion Criteria:
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Knee injury in the 1 month before the initial study evaluation
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Knee surgery within 1 year before the initial study evaluation
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Pace-maker or defibrillator, 2nd or 3rd degree heart block, or other abnormal rhythms
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Current diagnosis of diabetes mellitus, a fasting glucose>100mg/dl or >140 mg/dl 2 hour after a glucose challenge
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Current diagnosis of an inflammatory condition (e.g. rheumatoid arthritis, gout, etc)
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Untreated thyroid disease
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Morbid obesity (body mass index >35)
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Neuropathy or nerve damage
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Stroke or transient-ischemic attacks (mini-stroke)
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Recent diagnosis of congestive heart failure or heart attack
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Use of prednisone or chemotherapy, steroid or other joint or ant-inflammatory agents in the past 3 months
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Current use of medications that influence heart rate
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Cognitive impairment that limits your ability to provide informed consent
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Pregnancy
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | NIA Clinical Research Unit | Baltimore | Maryland | United States | 21225 |
Sponsors and Collaborators
- National Institute on Aging (NIA)
Investigators
- Principal Investigator: Shari M. Ling, MD, National Institute on Aging (NIA)
Study Documents (Full-Text)
None provided.More Information
Publications
- Handel TM, Johnson Z, Crown SE, Lau EK, Proudfoot AE. Regulation of protein function by glycosaminoglycans--as exemplified by chemokines. Annu Rev Biochem. 2005;74:385-410. Review.
- Roos EM. Joint injury causes knee osteoarthritis in young adults. Curr Opin Rheumatol. 2005 Mar;17(2):195-200. Review.
- Saeed RW, Varma S, Peng-Nemeroff T, Sherry B, Balakhaneh D, Huston J, Tracey KJ, Al-Abed Y, Metz CN. Cholinergic stimulation blocks endothelial cell activation and leukocyte recruitment during inflammation. J Exp Med. 2005 Apr 4;201(7):1113-23.
- AG0105