Evaluation of the Analgesia Nociception Index With Varying Remifentanil Concentrations Under Sevoflurane
Study Details
Study Description
Brief Summary
Analgesia Nociception Index（ANI）which is derived by heart rate variability can be used to detect noxious stimulation during propofol while changing remifentanil concentrations.The aim of this study is to evaluate whether ANI can detect noxious stimulation under sevoflurane with different concentrations of remifentanil.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Detailed Description
General anesthesia with sevoflurane and remifentanil is widely used in minor surgeries.Monitoring noxious stimulation during general anesthesia is still worth further studies and reaching clinical consensus.Analgesia Nociception Index can be used to detect noxious stimulation during propofol while changing remifentanil concentrations.The aim of this study is to evaluate whether ANI can detect noxious stimulation under sevoflurane with different concentrations of remifentanil.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| sevoflurane with remifentanil patients receive standardized sevoflurane with different concentrations of remifentanil |
Device: tetanic stimulation
Using a standard muscle relaxometer to generate tetanic stimulation
Procedure: skin incision
To assess the predictive performance of ANI, when ANI indicated sufficient concentration of remifentanil induced by tetanic stimulation, applied skin incision under this concentration to verify the prediction of ANI performance.
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Outcome Measures
Primary Outcome Measures
- Evaluation of ANI at different analgesic levels [Change from Baseline ANI that 2 minutes after applied tetanic stilumation]
Tetanic stimulations are applied at different effect-site concentrations of remifentanil under sevoflurane. ANI is range from 0-100. Bigger number means better analgesic level. 50-70 is considered to be under adequate analgesia. Tetanic stimulation is a standard tester of nociceptive stimulus. The number of ANI will fall down if the patient is feeling pain.
Secondary Outcome Measures
- Evaluation of Systolic Blood Pressure at different analgesic levels [Change from Baseline Systolic Blood Pressure that 2 minutes after applied tetanic stilumation]
Systolic Blood Pressure will go up if patient is feeling pain.
- Evaluation of Heart Rate at different analgesic levels [Change from Baseline Heart Rate that 2 minutes after applied tetanic stilumation]
Heart Rate will go up if patient is feeling pain.
- Evaluation of Bispectral Index at different analgesic levels [Change from Baseline Bispectral Index that 2 minutes after applied tetanic stilumation]
Bispectral Index will go up if patient is feeling pain.
- To verify the prediction of ANI performance [Change from Baseline Bispectral Index that 2 minutes after applied skin incision]
when ANI indicated sufficient concentration of remifentanil induced by tetanic stilumation, applied skin incision under this concentration, ANI and hemodynamic variations will not imply that patient is feeling pain.
Eligibility Criteria
Criteria
Inclusion Criteria:
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Age between 18- 65 years
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ASA physical status I or II
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Elective surgery in general anesthesia planned
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Written informed consent
Exclusion Criteria:
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Use of CNS-active medication or abuse of alcohol
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Presents of any neuromuscular or neurologic disease
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History of cardiac arrhythmia
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Pregnancy or using pacemaker
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Beijing Chao Yang Hospital | Beijing | Beijing | China | 100020 |
Sponsors and Collaborators
- Beijing Chao Yang Hospital
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 00375930