CompassHER2-pCR: Decreasing Chemotherapy for Breast Cancer Patients After Pre-surgery Chemo and Targeted Therapy

• Sponsor: ECOG-ACRIN Cancer Research Group (Other)
• Overall Status: Recruiting
• CT.gov ID: NCT04266249
• Collaborator: National Cancer Institute (NCI) (NIH)
• Enrollment: 2,156
• Locations: 912
• Arms: 2
• Anticipated Duration (Months): 36.6
• Patients Per Site: 2.4
• Patients Per Site Per Month: 0.1

Study Details

Study Description

Brief Summary

This trial studies how well paclitaxel, trastuzumab, and pertuzumab work in eliminating further chemotherapy after surgery in patients with HER2-positive stage II-IIIa breast cancer who have no cancer remaining at surgery (either in the breast or underarm lymph nodes) after pre-operative chemotherapy and HER2-targeted therapy. Drugs used in chemotherapy, such as paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Trastuzumab and pertuzumab are both a form of "targeted therapy" because they work by attaching themselves to specific molecules (receptors) on the surface of tumor cells, known as HER2 receptors. When these drugs attach to HER2 receptors, the signals that tell the cells to grow are blocked and the tumor cell may be marked for destruction by the body's immune system. Giving paclitaxel, trastuzumab, and pertuzumab may enable fewer chemotherapy drugs to be given without compromising patient outcomes compared to the usual treatment.

Condition or Disease	Intervention/Treatment	Phase
Anatomic Stage II Breast Cancer AJCC v8; Anatomic Stage IIA Breast Cancer AJCC v8; Anatomic Stage IIB Breast Cancer AJCC v8; Anatomic Stage IIIA Breast Cancer AJCC v8; Invasive Breast Carcinoma; Prognostic Stage II Breast Cancer AJCC v8; Prognostic Stage IIA Breast Cancer AJCC v8; Prognostic Stage IIB Breast Cancer AJCC v8; Prognostic Stage IIIA Breast Cancer AJCC v8	Drug: Docetaxel; Procedure: Lumpectomy; Procedure: Mastectomy; Drug: Nab-paclitaxel; Drug: Paclitaxel; Biological: Pertuzumab; Radiation: Radiation Therapy; Biological: Trastuzumab; Biological: Trastuzumab Emtansine	Phase 2

Detailed Description

PRIMARY OBJECTIVES:

1. To determine if 3-year recurrence-free survival (RFS) is greater than 92% among clinical stages II or IIIa patients with HER2-positive breast cancer who achieve pathologic complete response (pCR) (ypT0/is ypN0) after preoperative therapy with 12 weeks of a taxane, trastuzumab (or Food and Drug Administration [FDA] approved biosimilar) and pertuzumab (THP x 12).

SECONDARY OBJECTIVES:

1. To determine 3-year IDFS (invasive disease-free survival), DDFS (distant disease-free survival), DRFS (distant relapse-free survival), RFI (recurrence-free interval), OS (overall survival) and breast cancer-specific survival in patients who achieve pCR (and by pretreatment clinical stage). (Secondary Clinical Objective) II. To determine 3-year EFS (event-free survival) in all patients from time of study registration. (Secondary Clinical Objective) III. To evaluate safety and tolerability for all patients during the pre-operative phase and for patients who attain pCR and de-escalate therapy (Arm A) until the completion of post-surgery protocol assigned therapy (i.e. until the end of trastuzumab and pertuzumab [HP] therapy). (Secondary Clinical Objective) IV. To evaluate the association of estrogen receptor (ER) status in the untreated primary tumor with pathologic response and with long-term survival outcomes (including RFS, EFS, IDFS, DDFS, DRFS, RFI, OS, and breast cancer-specific survival). (Secondary Correlative Objective) V. To evaluate the associations of detection of circulating tumor cells (CTCs) in the blood at baseline with pCR. (Secondary Correlative Objective) VI. To evaluate the association of detection of CTCs in the blood at baseline, after 3 weeks of THP, after 12 weeks of THP (before surgery), after surgery before any additional therapy, and after completion of HER2-targeted therapy with RFS in patients who achieve pCR or not. (Secondary Correlative Objective)

EXPLORATORY OBJECTIVES:

1. To determine 3-year RFS, IDFS (invasive disease-free survival), DDFS (distant disease-free survival), DRFS (distant relapse-free survival), RFI (recurrence-free interval), OS (overall survival) and breast cancer-specific survival in patients who do not achieve pCR (and by pretreatment clinical stage). (Exploratory Clinical Objective) II. To determine the pathologic response to THP neoadjuvant therapy, as assessed by residual cancer burden (RCB). (Exploratory Clinical Objective) III. To determine the association between residual cancer burden (RCB) and all described standardized definitions for efficacy end points (STEEP) criteria outcomes. (Exploratory Clinical Objective) IV. To determine the false negative rate (FNR) of limited staging procedures (defined as sentinel lymph node biopsy [SLNB] plus removal of clipped node) in patients who undergo such procedures with a planned axillary lymph node dissection (ALND). (Exploratory Clinical Objective) V. To determine axillary pCR rates as a function of the burden of disease at presentation as determined on pre-treatment ultrasound (US) and the axillary staging technique (SLNB plus ensuring removal of clipped node versus ALND). (Exploratory Clinical Objective) VI. To evaluate the associations between plasma tumor cell-free deoxyribonucleic acid (DNA) (cfDNA) tumor-specific mutations (baseline and after therapy) with pathologic response and long-term outcomes (including RFS, EFS, IDFS, DDFS, DRFS, RFI, OS, and breast cancer-specific survival). (Exploratory Correlative Objective) VII. To evaluate the associations between tumor infiltrating lymphocytes (TILs) and immune activation gene signatures in the baseline tumor with pathologic response and long-term outcomes (including RFS, EFS, IDFS, DDFS, DRFS, RFI, OS and breast cancer-specific survival). (Exploratory Correlative Objective) VIII. To determine the frequency of change in intrinsic subtype between pretreatment tumor specimen and residual disease at the time of surgery. (Exploratory Correlative Objective) IX. To evaluate the associations between DNA copy number, DNA mutations, ribonucleic acid (RNA) expression and protein expression in the baseline tumor and changes from baseline to post-THP therapy with pathologic response and long-term outcomes (including RFS, EFS, IDFS, DDFS, DRFS, RFI, OS, and breast cancer-specific survival). (Exploratory Correlative Objective)

OUTLINE:

PRE-OPERATIVE/NEOADJUVANT THERAPY: Patients receive either paclitaxel or nab-paclitaxel intravenously (IV) on days 1, 8 and 15, or docetaxel IV on day 1 at the discretion of the treating oncologist. Patients also receive trastuzumab IV on day 1 or days 1, 8, and 15, and pertuzumab IV on day 1. Treatment repeats every 21 days for up to 4 cycles in the absence of disease progression or unacceptable toxicity.

SURGERY: Within 42 days after last dose of neoadjuvant therapy, patients undergo standard of care lumpectomy and/or mastectomy.

POST-OPERATIVE/ADJUVANT THERAPY: Patients are assigned to 1 of 2 arms.

ARM A: Patients with pCR after surgery receive trastuzumab and pertuzumab IV on day 1. Treatment repeats every 21 days for up to 13 cycles in the absence of disease progression or unacceptable toxicity. Patients may also undergo standard of care radiation therapy and receive hormone therapy if appropriate.

ARM B: Patients with remaining tumor after surgery receive standard of care trastuzumab emtansine for 14 doses in the absence of disease progression or unacceptable toxicity. Patients may also receive additional standard of care chemotherapy, as well as hormone therapy if appropriate.

After completion of study treatment, patients are followed up every 3 months for 2 years, every 6 months for 2-5 years, then annually for 5-15 years from date of surgery.

Study Design

• Study Type: Interventional
• Anticipated Enrollment: 2156 participants
• Allocation: Non-Randomized
• Intervention Model: Parallel Assignment
• Masking: None (Open Label)
• Primary Purpose: Treatment
• Official Title: (CompassHER2-pCR): Preoperative THP and Postoperative HP in Patients Who Achieve a Pathologic Complete Response
• Actual Study Start Date: Feb 11, 2020
• Anticipated Primary Completion Date: Feb 28, 2023
• Anticipated Study Completion Date: Feb 28, 2023

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Arm A (pCR after surgery) PRE-OPERATIVE/NEOADJUVANT THERAPY: Patients receive either paclitaxel or nab-paclitaxel IV on days 1, 8 and 15, or docetaxel IV on day 1 at the discretion of the treating oncologist. Patients also receive trastuzumab IV on day 1 or days 1, 8, and 15, and pertuzumab IV on day 1. Treatment repeats every 21 days for up to 4 cycles in the absence of disease progression or unacceptable toxicity. SURGERY: Within 42 days after last dose of neoadjuvant therapy, patients undergo standard of care lumpectomy and/or mastectomy. POST-OPERATIVE.ADJUVANT THERAPY: Patients with pCR after surgery receive trastuzumab and pertuzumab IV on day 1. Treatment repeats every 21 days for up to 13 cycles in the absence of disease progression or unacceptable toxicity. Patients may also undergo standard of care radiation therapy and receive hormone therapy if appropriate.	Drug: Docetaxel; Given IV; Other Names: Docecad RP56976 Taxotere Taxotere Injection Concentrate ; Procedure: Lumpectomy; Undergo lumpectomy; Other Names: Lumpectomy of Breast Partial Mastectomy ; Procedure: Mastectomy; Undergo mastectomy; Other Names: Mammectomy ; Drug: Nab-paclitaxel; Given IV; Other Names: ABI 007 ABI-007 Abraxane Albumin-bound Paclitaxel Albumin-Stabilized Nanoparticle Paclitaxel Nanoparticle Albumin-bound Paclitaxel Nanoparticle Paclitaxel Paclitaxel Albumin paclitaxel albumin-stabilized nanoparticle formulation protein-bound paclitaxel ; Drug: Paclitaxel; Given IV; Other Names: Anzatax Asotax Bristaxol Praxel Taxol Taxol Konzentrat ; Biological: Pertuzumab; Given IV; Other Names: 2C4 2C4 Antibody MoAb 2C4 Monoclonal Antibody 2C4 Omnitarg Perjeta rhuMAb2C4 RO4368451 ; Radiation: Radiation Therapy; Undergo radiation therapy; Other Names: Cancer Radiotherapy Irradiate irradiated irradiation RADIATION Radiation Therapy, NOS Radiotherapeutics Radiotherapy RT Therapy, Radiation ; Biological: Trastuzumab; Given IV; Other Names: ABP 980 ALT02 Anti-c-ERB-2 Anti-c-erbB2 Monoclonal Antibody Anti-ERB-2 Anti-erbB-2 Anti-erbB2 Monoclonal Antibody Anti-HER2/c-erbB2 Monoclonal Antibody Anti-p185-HER2 c-erb-2 Monoclonal Antibody HER2 Monoclonal Antibody Herceptin Herceptin Biosimilar PF-05280014 Herceptin Trastuzumab Biosimilar PF-05280014 Herzuma MoAb HER2 Monoclonal Antibody c-erb-2 Monoclonal Antibody HER2 Ogivri Ontruzant PF-05280014 rhuMAb HER2 RO0452317 SB3 Trastuzumab Biosimilar ABP 980 Trastuzumab Biosimilar ALT02 trastuzumab biosimilar EG12014 Trastuzumab Biosimilar HLX02 Trastuzumab Biosimilar PF-05280014 Trastuzumab Biosimilar SB3 Trastuzumab-dkst Trastuzumab-dttb Trastuzumab-pkrb Trastuzumab-QYYP Trazimera
Experimental: Arm B (residual invasive disease after surgery) PRE-OPERATIVE/NEOADJUVANT THERAPY: Patients receive either paclitaxel or nab-paclitaxel IV on days 1, 8 and 15, or docetaxel IV on day 1 at the discretion of the treating oncologist. Patients also receive trastuzumab IV on day 1 or days 1, 8, and 15, and pertuzumab IV on day 1. Treatment repeats every 21 days for up to 4 cycles in the absence of disease progression or unacceptable toxicity. SURGERY: Within 42 days after last dose of neoadjuvant therapy, patients undergo standard of care lumpectomy and/or mastectomy. POST-OPERATIVE/ADJUVANT THERAPY: Patients with remaining tumor after surgery receive standard of care trastuzumab emtansine for 14 doses in the absence of disease progression or unacceptable toxicity. Patients may also receive additional standard of care chemotherapy, as well as hormone therapy if appropriate.	Drug: Docetaxel; Given IV; Other Names: Docecad RP56976 Taxotere Taxotere Injection Concentrate ; Procedure: Lumpectomy; Undergo lumpectomy; Other Names: Lumpectomy of Breast Partial Mastectomy ; Procedure: Mastectomy; Undergo mastectomy; Other Names: Mammectomy ; Drug: Nab-paclitaxel; Given IV; Other Names: ABI 007 ABI-007 Abraxane Albumin-bound Paclitaxel Albumin-Stabilized Nanoparticle Paclitaxel Nanoparticle Albumin-bound Paclitaxel Nanoparticle Paclitaxel Paclitaxel Albumin paclitaxel albumin-stabilized nanoparticle formulation protein-bound paclitaxel ; Drug: Paclitaxel; Given IV; Other Names: Anzatax Asotax Bristaxol Praxel Taxol Taxol Konzentrat ; Biological: Pertuzumab; Given IV; Other Names: 2C4 2C4 Antibody MoAb 2C4 Monoclonal Antibody 2C4 Omnitarg Perjeta rhuMAb2C4 RO4368451 ; Biological: Trastuzumab; Given IV; Other Names: ABP 980 ALT02 Anti-c-ERB-2 Anti-c-erbB2 Monoclonal Antibody Anti-ERB-2 Anti-erbB-2 Anti-erbB2 Monoclonal Antibody Anti-HER2/c-erbB2 Monoclonal Antibody Anti-p185-HER2 c-erb-2 Monoclonal Antibody HER2 Monoclonal Antibody Herceptin Herceptin Biosimilar PF-05280014 Herceptin Trastuzumab Biosimilar PF-05280014 Herzuma MoAb HER2 Monoclonal Antibody c-erb-2 Monoclonal Antibody HER2 Ogivri Ontruzant PF-05280014 rhuMAb HER2 RO0452317 SB3 Trastuzumab Biosimilar ABP 980 Trastuzumab Biosimilar ALT02 trastuzumab biosimilar EG12014 Trastuzumab Biosimilar HLX02 Trastuzumab Biosimilar PF-05280014 Trastuzumab Biosimilar SB3 Trastuzumab-dkst Trastuzumab-dttb Trastuzumab-pkrb Trastuzumab-QYYP Trazimera ; Biological: Trastuzumab Emtansine; Given IV; Other Names: Ado Trastuzumab Emtansine ADO-Trastuzumab Emtansine Kadcyla PRO132365 RO5304020 T-DM1 Trastuzumab-DM1 Trastuzumab-MCC-DM1 Trastuzumab-MCC-DM1 Antibody-Drug Conjugate Trastuzumab-MCC-DM1 Immunoconjugate

Outcome Measures

Primary Outcome Measures

1. Recurrence-free survival (RFS) [Up to 3 years after end of treatment]

   Events include recurrence of ipsilateral invasive breast tumor, recurrence of locoregional invasive breast tumor, and distant recurrence. Survival curve estimated using Kaplan-Meier method in the overall analysis population and by pretreatment clinical stage and estrogen receptor (ER) status. Greenwood method will be used to estimate the 95% confidence interval for 3-year rate.

Secondary Outcome Measures

1. Invasive disease-free survival (IDFS) [Up to 3 years after the end of treatment]

   Events include recurrence of ipsilateral invasive breast tumor, recurrence of locoregional invasive breast tumor, distant recurrence, contralateral invasive breast cancer, and second primary non-breast invasive cancer (other than squamous or basal cell skin cancer). Survival curve estimated using Kaplan-Meier method in the overall analysis population and by pretreatment clinical stage and ER status. The analysis will be descriptive and there will be no statistical test.

2. Distant disease-free survival (DDFS) [Up to 3 years after the end of treatment]

   Events include distant recurrence and second primary non-breast invasive cancer (other than squamous or basal cell skin cancer). Survival curve estimated using Kaplan-Meier method in the overall analysis population and by pretreatment clinical stage and ER status. The analysis will be descriptive and there will be no statistical test.

3. Distant relapse-free survival (DRFS) [U to 3 years after the end of treatment]

   Survival curve estimated using Kaplan-Meier method in the overall analysis population and by pretreatment clinical stage and ER status. The analysis will be descriptive and there will be no statistical test.

4. Recurrence-free interval (RFI) [Up to 3 years after the end of treatment]

   Survival curve estimated using Kaplan-Meier method in the overall analysis population and by pretreatment clinical stage and ER status. The analysis will be descriptive and there will be no statistical test.

5. Overall survival (OS) [From date of surgery until the date of death from any cause, assessed up to 3 years after the end of treatment]

   Survival curve estimated using Kaplan-Meier method in the overall analysis population and by pretreatment clinical stage and ER status. The analysis will be descriptive and there will be no statistical test.

6. Event-free survival (EFS) [Up to 3 years after the end of treatment]

   Survival curve estimated using Kaplan-Meier method in the overall analysis population and by pretreatment clinical stage and ER status. The analysis will be descriptive and there will be no statistical test.

7. Incidence of adverse events (AEs) [Up to 1 week after cycle 4 (all patients) and/or up to cycle 13 post-surgery (Arm A only) (each cycle is 21 days)]

   Will be graded using the National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) version (v)5.0. All treatment-emergent and baseline adverse events and hematological/biochemical toxicities based on laboratory measurements, as well as drug related AEs, will be summarized by NCI CTCAE v5.0 worst grade. The incidence of deaths and treatment-emergent serious adverse events (defined as number of patients experiencing the AE divided by all treated patients) will be summarized using binominal proportions and binomial exact 95% confidence intervals. The incidence of adverse events leading to discontinuation of protocol therapy will be summarized and listed as well.

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years and Older
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Inclusion Criteria:

• Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1

• Patient must have histologically confirmed HER2-positive primary invasive breast carcinoma, determined by local testing. The tumor must have either HER2 IHC result of 3+ or HER2/CEP17 ratio > 2 with > 4.0 HER2 signals per cell by ISH. Tumors with HER2/CEP17 ISH ratio < 2 are ineligible, even if HER2 copy number is > 6, unless HER2 IHC result is 3+.

• Patients hormone receptor (estrogen receptor [ER] and progesterone receptor [PR]) status must be known and will be determined by local testing. Patients with either hormone receptor -positive or hormone receptor- negative HER2-positive breast cancer are eligible

• Patients must have AJCC 8th Edition stage II or IIIa according to anatomic staging table at diagnosis

• Patients without nodal involvement (cN0) are eligible if T size > 2.0 cm (T2-3)

• Patients with nodal involvement (cN1-2) are eligible if T1-3

• Patients with clinical T4 or N3 disease are not eligible

• Patient must be willing and able (i.e., have no contraindication) to receive standard adjuvant therapy, consisting of HER2-directed therapy, radiation (if indicated) and endocrine therapy (if ER+) if achieving pCR at surgery

• Patient with bilateral invasive breast cancers are eligible if both cancers are HER2-positive (as defined in 3.1.3) at least one meets protocol eligibility and neither cancer renders the patient ineligible (i.e. per eligibility 3.1.5)

• Patients with multiple ipsilateral invasive tumors are eligible as long as all tumors are HER2-positive, and at least one tumor focus meets eligibility criteria (per eligibility 3.1.5). Multiple lesions that appear part of the same index tumor do not require additional biopsy/HER2 testing. Multiple lesions that appear part of the same index tumor do not require additional biopsy/HER2 testing. However, even if biopsy is not deemed necessary, consideration should be given to placing a clip in any lesion that is 1 cm or further from the primary tumor to ensure that all tumor is removed at surgery AND that the pathologist can locate all primary sites of tumor to assess pathologic response at surgery.

• Patients with a history of other non-breast malignancies are eligible if they have been disease-free for at least 5 years, and are deemed by the investigator to be at low risk for recurrence of that malignancy.

• Patients with the following cancers are eligible if diagnosed and treated within the past 5 years: cervical cancer in situ, basal cell or squamous cell carcinoma of the skin, and localized papillary or follicular thyroid cancer who have completed recommended treatment including surgery. Patients with any other cancers within the last 5 years are ineligible.

• Patents must have a left ventricular ejection fraction (LVEF) within normal institutional parameters (or > 50%)

• Patients must not have > grade 1 peripheral neuropathy of any etiology.

• Patients must have a bilateral mammogram and a diagnostic breast ultrasound [on the side of the cancer(s)] (with or without breast MRI) performed at screening. An axillary ultrasound on the side of the cancer(s) is also required. However, if a patient has a negative axillary physical exam and a baseline MRI without suspicious lymph nodes performed before axillary ultrasound, axillary ultrasound may be omitted. Comprehensive breast and axillary imaging must be performed within 42 days of registration (i.e. the patient's mammogram/ breast ultrasound /axillary ultrasound OR their breast MRI).

• Baseline imaging of the ipsilateral axilla by ultrasound or breast MRI is mandatory. For subjects with axillary lymph node(s) suspicious on clinical exam or imaging, patient must be willing to have a needle aspiration or core biopsy to determine the presence of metastatic disease in the lymph nodes. A clip must be placed in the involved axillary lymph node. (If there are more than 1 suspicious axillary nodes, only one clipped node is required).

• Patient of childbearing potential and sexually active patients must use accepted and effective method(s) of contraception or to abstain from sexual intercourse for the duration of their participation in the study and for 7 months after the last dose of study treatment.

• Patient must be willing and able to sign informed consent

• Leukocytes >= 3,000/mcL (obtained =< 28 days prior to protocol registration)

• Absolute neutrophil count >= 1,500/mcL (obtained =< 28 days prior to protocol registration)

• Platelets >= 100,000/mcL (obtained =< 28 days prior to protocol registration)

• Total bilirubin =< 1.5 x institutional upper limit of normal (ULN) (obtained =< 28 days prior to protocol registration)

• Aspartate aminotransferase (AST) (serum glutamic-oxaloacetic transaminase [SGOT])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) =< 2.5 x institutional ULN (obtained =< 28 days prior to protocol registration)

• Creatinine =< 1.5 x institutional ULN (obtained =< 28 days prior to protocol registration)

• Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial

• For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy, if indicated

• Patients with a history of hepatitis C virus (HCV) infection must have been treated and cured. For patients with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load

Exclusion Criteria:

• Patients must not have impaired decision-making capacity

• Patient must not have a history of any prior (ipsilateral or contralateral) invasive breast cancer

• One exception: a patient with a history of T1N0 triple negative breast cancer diagnosed more than 10 years earlier, who remains disease free is eligible

• Patient must not have prior ipsilateral ductal breast carcinoma in situ (DCIS). Patients with prior lobular breast carcinoma in situ (LCIS), atypical hyperplasia, other high risk benign lesions or contralateral DCIS (without evidence of microinvasion) are eligible

• NOTE: Patients currently receiving endocrine therapy for prior contralateral DCIS are eligible

• Patient must not have stage IV (metastatic) breast cancer

• Staging studies (computed tomography [CT] chest/abdomen/pelvis and a bone scan or positron emission tomography [PET]-CT scan) are required for stage III disease or those with abnormal baseline liver function tests (LFTs), symptoms (e.g. new bone pain) or abnormal physical exam findings (National Comprehensive Cancer Network [NCCN] guidelines version [V]1.2019)

• Patient must not have T4 and/or N3 disease, including inflammatory breast cancer

• Patient must not have any prior treatment for the current breast cancer, including surgery, chemotherapy, hormonal therapy, radiation or experimental therapy

• Patients must not have > grade 1 peripheral neuropathy of any etiology

• Patient must not have a concurrent serious medical condition that would preclude completion of study therapy. For example, uncontrolled hypertension (systolic > 180 mm Hg and/or diastolic > 100 mm Hg) or clinically significant (i.e. active) cardiovascular disease: cerebrovascular accident/stroke or myocardial infarction within 6 months prior to registration, unstable angina, congestive heart failure (CHF) or serious cardiac arrhythmia requiring medication and other concurrent serious diseases that may interfere with planned treatment

• Patient must not be pregnant or breast-feeding due to the potential harm to an unborn fetus and possible risk for adverse events in nursing infants with the treatment regimens being used. Patients must also not expect to conceive from the time of registration, while on study treatment, and until at least 7 months after the last dose of study treatment. All patients of childbearing potential must have a blood test or urine study within 14 days prior to registration to rule out pregnancy

• All patients of childbearing potential is anyone, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point, 2) has not undergone a hysterectomy or bilateral oophorectomy; or 3) has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	University of Alabama at Birmingham Cancer Center	Birmingham	Alabama	United States	35233
2	Anchorage Associates in Radiation Medicine	Anchorage	Alaska	United States	98508
3	Anchorage Radiation Therapy Center	Anchorage	Alaska	United States	99504
4	Alaska Breast Care and Surgery LLC	Anchorage	Alaska	United States	99508
5	Alaska Oncology and Hematology LLC	Anchorage	Alaska	United States	99508
6	Alaska Women's Cancer Care	Anchorage	Alaska	United States	99508
7	Anchorage Oncology Centre	Anchorage	Alaska	United States	99508
8	Katmai Oncology Group	Anchorage	Alaska	United States	99508
9	Providence Alaska Medical Center	Anchorage	Alaska	United States	99508
10	Fairbanks Memorial Hospital	Fairbanks	Alaska	United States	99701
11	Kingman Regional Medical Center	Kingman	Arizona	United States	86401
12	Cancer Center at Saint Joseph's	Phoenix	Arizona	United States	85004
13	University of Arizona Cancer Center-Orange Grove Campus	Tucson	Arizona	United States	85704
14	Banner University Medical Center - Tucson	Tucson	Arizona	United States	85719
15	University of Arizona Cancer Center-North Campus	Tucson	Arizona	United States	85719
16	Mercy Hospital Fort Smith	Fort Smith	Arkansas	United States	72903
17	CHI Saint Vincent Cancer Center Hot Springs	Hot Springs	Arkansas	United States	71913
18	NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro	Jonesboro	Arkansas	United States	72401
19	Mission Hope Medical Oncology - Arroyo Grande	Arroyo Grande	California	United States	93420
20	PCR Oncology	Arroyo Grande	California	United States	93420
21	Sutter Auburn Faith Hospital	Auburn	California	United States	95602
22	Sutter Cancer Centers Radiation Oncology Services-Auburn	Auburn	California	United States	95603
23	Alta Bates Summit Medical Center-Herrick Campus	Berkeley	California	United States	94704
24	Providence Saint Joseph Medical Center/Disney Family Cancer Center	Burbank	California	United States	91505
25	Mills-Peninsula Medical Center	Burlingame	California	United States	94010
26	Sutter Cancer Centers Radiation Oncology Services-Cameron Park	Cameron Park	California	United States	95682
27	Eden Hospital Medical Center	Castro Valley	California	United States	94546
28	Sutter Davis Hospital	Davis	California	United States	95616
29	Epic Care-Dublin	Dublin	California	United States	94568
30	Bay Area Breast Surgeons Inc	Emeryville	California	United States	94608
31	Epic Care Partners in Cancer Care	Emeryville	California	United States	94608
32	Palo Alto Medical Foundation-Fremont	Fremont	California	United States	94538
33	Washington Hospital	Fremont	California	United States	94538
34	Keck Medicine of USC Huntington Beach	Huntington Beach	California	United States	92648
35	Los Angeles County-USC Medical Center	Los Angeles	California	United States	90033
36	USC / Norris Comprehensive Cancer Center	Los Angeles	California	United States	90033
37	Contra Costa Regional Medical Center	Martinez	California	United States	94553-3156
38	Fremont - Rideout Cancer Center	Marysville	California	United States	95901
39	Memorial Medical Center	Modesto	California	United States	95355
40	Palo Alto Medical Foundation-Camino Division	Mountain View	California	United States	94040
41	Palo Alto Medical Foundation-Gynecologic Oncology	Mountain View	California	United States	94040
42	USC Norris Oncology/Hematology-Newport Beach	Newport Beach	California	United States	92663
43	Alta Bates Summit Medical Center - Summit Campus	Oakland	California	United States	94609
44	Bay Area Tumor Institute	Oakland	California	United States	94609
45	Saint Joseph Hospital - Orange	Orange	California	United States	92868
46	Desert Regional Medical Center	Palm Springs	California	United States	92262
47	Palo Alto Medical Foundation Health Care	Palo Alto	California	United States	94301
48	Stanford Cancer Institute Palo Alto	Palo Alto	California	United States	94304
49	Keck Medical Center of USC Pasadena	Pasadena	California	United States	91105
50	Sutter Cancer Centers Radiation Oncology Services-Roseville	Roseville	California	United States	95661
51	Sutter Roseville Medical Center	Roseville	California	United States	95661
52	Sutter Medical Center Sacramento	Sacramento	California	United States	95816
53	Saint Helena Hospital	Saint Helena	California	United States	94574
54	Salinas Valley Memorial	Salinas	California	United States	93901
55	Zuckerberg San Francisco General Hospital	San Francisco	California	United States	94110
56	California Pacific Medical Center-Pacific Campus	San Francisco	California	United States	94115
57	Stanford Cancer Center South Bay	San Jose	California	United States	95124
58	Pacific Central Coast Health Center-San Luis Obispo	San Luis Obispo	California	United States	93401
59	Palo Alto Medical Foundation-Santa Cruz	Santa Cruz	California	United States	95065
60	Mission Hope Medical Oncology - Santa Maria	Santa Maria	California	United States	93444
61	Sutter Pacific Medical Foundation	Santa Rosa	California	United States	95403
62	Palo Alto Medical Foundation-Sunnyvale	Sunnyvale	California	United States	94086
63	Gene Upshaw Memorial Tahoe Forest Cancer Center	Truckee	California	United States	96161
64	Sutter Cancer Centers Radiation Oncology Services-Vacaville	Vacaville	California	United States	95687
65	Sutter Solano Medical Center/Cancer Center	Vallejo	California	United States	94589
66	Epic Care Cyberknife Center	Walnut Creek	California	United States	94597
67	Rocky Mountain Cancer Centers-Aurora	Aurora	Colorado	United States	80012
68	The Medical Center of Aurora	Aurora	Colorado	United States	80012
69	University of Colorado Hospital	Aurora	Colorado	United States	80045
70	Boulder Community Foothills Hospital	Boulder	Colorado	United States	80303
71	Rocky Mountain Cancer Centers-Boulder	Boulder	Colorado	United States	80304
72	Rocky Mountain Cancer Centers - Centennial	Centennial	Colorado	United States	80112
73	Penrose-Saint Francis Healthcare	Colorado Springs	Colorado	United States	80907
74	Rocky Mountain Cancer Centers-Penrose	Colorado Springs	Colorado	United States	80907
75	UCHealth Memorial Hospital Central	Colorado Springs	Colorado	United States	80909
76	Memorial Hospital North	Colorado Springs	Colorado	United States	80920
77	Saint Francis Cancer Center	Colorado Springs	Colorado	United States	80923
78	UCHealth - Cherry Creek	Denver	Colorado	United States	80206
79	The Women's Imaging Center	Denver	Colorado	United States	80209
80	Porter Adventist Hospital	Denver	Colorado	United States	80210
81	Colorado Blood Cancer Institute	Denver	Colorado	United States	80218
82	Presbyterian - Saint Lukes Medical Center - Health One	Denver	Colorado	United States	80218
83	Rocky Mountain Cancer Centers-Midtown	Denver	Colorado	United States	80218
84	Rocky Mountain Cancer Centers-Rose	Denver	Colorado	United States	80220
85	Rose Medical Center	Denver	Colorado	United States	80220
86	Western Surgical Care	Denver	Colorado	United States	80220
87	Mercy Medical Center	Durango	Colorado	United States	81301
88	Southwest Oncology PC	Durango	Colorado	United States	81301
89	Mountain Blue Cancer Care Center - Swedish	Englewood	Colorado	United States	80113
90	Rocky Mountain Cancer Centers - Swedish	Englewood	Colorado	United States	80113
91	Swedish Medical Center	Englewood	Colorado	United States	80113
92	The Melanoma and Skin Cancer Institute	Englewood	Colorado	United States	80113
93	Poudre Valley Hospital	Fort Collins	Colorado	United States	80524
94	Cancer Care and Hematology-Fort Collins	Fort Collins	Colorado	United States	80528
95	Grand Valley Oncology	Grand Junction	Colorado	United States	81505
96	North Colorado Medical Center	Greeley	Colorado	United States	80631
97	UCHealth Greeley Hospital	Greeley	Colorado	United States	80631
98	UCHealth Highlands Ranch Hospital	Highlands Ranch	Colorado	United States	80129
99	Rocky Mountain Cancer Centers-Lakewood	Lakewood	Colorado	United States	80228
100	Saint Anthony Hospital	Lakewood	Colorado	United States	80228
101	Rocky Mountain Cancer Centers-Littleton	Littleton	Colorado	United States	80120
102	Littleton Adventist Hospital	Littleton	Colorado	United States	80122
103	Rocky Mountain Cancer Centers-Sky Ridge	Lone Tree	Colorado	United States	80124
104	Sky Ridge Medical Center	Lone Tree	Colorado	United States	80124
105	UCHealth Lone Tree Health Center	Lone Tree	Colorado	United States	80124
106	Longmont United Hospital	Longmont	Colorado	United States	80501
107	Rocky Mountain Cancer Centers-Longmont	Longmont	Colorado	United States	80501
108	Medical Center of the Rockies	Loveland	Colorado	United States	80538
109	McKee Medical Center	Loveland	Colorado	United States	80539
110	Parker Adventist Hospital	Parker	Colorado	United States	80138
111	Saint Mary Corwin Medical Center	Pueblo	Colorado	United States	81004
112	Rocky Mountain Cancer Centers-Thornton	Thornton	Colorado	United States	80260
113	Hartford HealthCare - Saint Vincent's Medical Center	Bridgeport	Connecticut	United States	06606
114	Smilow Cancer Hospital-Derby Care Center	Derby	Connecticut	United States	06418
115	Smilow Cancer Hospital Care Center-Fairfield	Fairfield	Connecticut	United States	06824
116	Smilow Cancer Hospital Care Center at Glastonbury	Glastonbury	Connecticut	United States	06033
117	Smilow Cancer Hospital Care Center at Greenwich	Greenwich	Connecticut	United States	06830
118	Smilow Cancer Hospital Care Center - Guiford	Guilford	Connecticut	United States	06437
119	Hartford Hospital	Hartford	Connecticut	United States	06102
120	Smilow Cancer Hospital Care Center at Saint Francis	Hartford	Connecticut	United States	06105
121	Midstate Medical Center	Meriden	Connecticut	United States	06451
122	The Hospital of Central Connecticut	New Britain	Connecticut	United States	06050
123	Smilow Cancer Center/Yale-New Haven Hospital	New Haven	Connecticut	United States	06510
124	Yale University	New Haven	Connecticut	United States	06520
125	Yale-New Haven Hospital North Haven Medical Center	North Haven	Connecticut	United States	06473
126	Smilow Cancer Hospital-Orange Care Center	Orange	Connecticut	United States	06477
127	Smilow Cancer Hospital Care Center at Long Ridge	Stamford	Connecticut	United States	06902
128	Stamford Hospital/Bennett Cancer Center	Stamford	Connecticut	United States	06904
129	Smilow Cancer Hospital-Torrington Care Center	Torrington	Connecticut	United States	06790
130	Smilow Cancer Hospital Care Center-Trumbull	Trumbull	Connecticut	United States	06611
131	Smilow Cancer Hospital-Waterbury Care Center	Waterbury	Connecticut	United States	06708
132	Smilow Cancer Hospital Care Center - Waterford	Waterford	Connecticut	United States	06385
133	Beebe South Coastal Health Campus	Frankford	Delaware	United States	19945
134	Beebe Medical Center	Lewes	Delaware	United States	19958
135	Delaware Clinical and Laboratory Physicians PA	Newark	Delaware	United States	19713
136	Helen F Graham Cancer Center	Newark	Delaware	United States	19713
137	Medical Oncology Hematology Consultants PA	Newark	Delaware	United States	19713
138	Christiana Care Health System-Christiana Hospital	Newark	Delaware	United States	19718
139	Beebe Health Campus	Rehoboth Beach	Delaware	United States	19971
140	TidalHealth Nanticoke / Allen Cancer Center	Seaford	Delaware	United States	19973
141	Christiana Care Health System-Wilmington Hospital	Wilmington	Delaware	United States	19801
142	Sibley Memorial Hospital	Washington	District of Columbia	United States	20016
143	AdventHealth Altamonte	Altamonte Springs	Florida	United States	32701
144	Mount Sinai Comprehensive Cancer Center at Aventura	Aventura	Florida	United States	33180
145	UM Sylvester Comprehensive Cancer Center at Aventura	Aventura	Florida	United States	33180
146	AdventHealth Celebration	Celebration	Florida	United States	34747
147	Morton Plant Hospital	Clearwater	Florida	United States	33756
148	UM Sylvester Comprehensive Cancer Center at Coral Gables	Coral Gables	Florida	United States	33146
149	UM Sylvester Comprehensive Cancer Center at Deerfield Beach	Deerfield Beach	Florida	United States	33442
150	University of Florida Health Science Center - Gainesville	Gainesville	Florida	United States	32610
151	Memorial Regional Hospital/Joe DiMaggio Children's Hospital	Hollywood	Florida	United States	33021
152	Mayo Clinic in Florida	Jacksonville	Florida	United States	32224-9980
153	AdventHealth Kissimmee	Kissimmee	Florida	United States	34744
154	Mount Sinai Medical Center	Miami Beach	Florida	United States	33140
155	University of Miami Miller School of Medicine-Sylvester Cancer Center	Miami	Florida	United States	33136
156	UM Sylvester Comprehensive Cancer Center at Kendall	Miami	Florida	United States	33176
157	AdventHealth Medical Group Urology at Orlando	Orlando	Florida	United States	32803
158	AdventHealth Orlando	Orlando	Florida	United States	32803
159	AdventHealth East Orlando	Orlando	Florida	United States	32822
160	Memorial Hospital West	Pembroke Pines	Florida	United States	33028
161	UM Sylvester Comprehensive Cancer Center at Plantation	Plantation	Florida	United States	33324
162	Mease Countryside Hospital	Safety Harbor	Florida	United States	34695
163	Winter Haven Hospital	Winter Haven	Florida	United States	33881
164	AdventHealth Winter Park	Winter Park	Florida	United States	32792
165	Grady Health System	Atlanta	Georgia	United States	30303
166	Emory University Hospital Midtown	Atlanta	Georgia	United States	30308
167	Emory University Hospital/Winship Cancer Institute	Atlanta	Georgia	United States	30322
168	Emory Saint Joseph's Hospital	Atlanta	Georgia	United States	30342
169	Northside Hospital	Atlanta	Georgia	United States	30342
170	Hamilton Medical Center - Peeples Cancer Institute	Dalton	Georgia	United States	30720
171	Northside Hospital - Duluth	Duluth	Georgia	United States	30096
172	Northside Hospital - Gwinnett	Lawrenceville	Georgia	United States	30046
173	Lewis Cancer and Research Pavilion at Saint Joseph's/Candler	Savannah	Georgia	United States	31405
174	Suburban Hematology Oncology Associates - Snellville	Snellville	Georgia	United States	30078
175	Lewis Hall Singletary Oncology Center	Thomasville	Georgia	United States	31792
176	Saint Alphonsus Cancer Care Center-Boise	Boise	Idaho	United States	83706
177	Saint Luke's Cancer Institute - Boise	Boise	Idaho	United States	83712
178	Saint Alphonsus Cancer Care Center-Caldwell	Caldwell	Idaho	United States	83605
179	Kootenai Health - Coeur d'Alene	Coeur d'Alene	Idaho	United States	83814
180	Walter Knox Memorial Hospital	Emmett	Idaho	United States	83617
181	Saint Luke's Cancer Institute - Fruitland	Fruitland	Idaho	United States	83619
182	Idaho Urologic Institute-Meridian	Meridian	Idaho	United States	83642
183	Saint Luke's Cancer Institute - Meridian	Meridian	Idaho	United States	83642
184	Saint Alphonsus Medical Center-Nampa	Nampa	Idaho	United States	83686
185	Saint Luke's Cancer Institute - Nampa	Nampa	Idaho	United States	83686
186	Kootenai Clinic Cancer Services - Post Falls	Post Falls	Idaho	United States	83854
187	Kootenai Cancer Clinic	Sandpoint	Idaho	United States	83864
188	Saint Luke's Cancer Institute - Twin Falls	Twin Falls	Idaho	United States	83301
189	Saint Anthony's Health	Alton	Illinois	United States	62002
190	Rush - Copley Medical Center	Aurora	Illinois	United States	60504
191	Illinois CancerCare-Bloomington	Bloomington	Illinois	United States	61704
192	Illinois CancerCare-Canton	Canton	Illinois	United States	61520
193	Memorial Hospital of Carbondale	Carbondale	Illinois	United States	62902
194	SIH Cancer Institute	Carterville	Illinois	United States	62918
195	Illinois CancerCare-Carthage	Carthage	Illinois	United States	62321
196	Centralia Oncology Clinic	Centralia	Illinois	United States	62801
197	Mount Sinai Hospital Medical Center	Chicago	Illinois	United States	60608
198	Northwestern University	Chicago	Illinois	United States	60611
199	Rush University Medical Center	Chicago	Illinois	United States	60612
200	University of Illinois	Chicago	Illinois	United States	60612
201	Swedish Covenant Hospital	Chicago	Illinois	United States	60625
202	University of Chicago Comprehensive Cancer Center	Chicago	Illinois	United States	60637
203	Carle on Vermilion	Danville	Illinois	United States	61832
204	Cancer Care Specialists of Illinois - Decatur	Decatur	Illinois	United States	62526
205	Decatur Memorial Hospital	Decatur	Illinois	United States	62526
206	Illinois CancerCare-Dixon	Dixon	Illinois	United States	61021
207	Carle Physician Group-Effingham	Effingham	Illinois	United States	62401
208	Crossroads Cancer Center	Effingham	Illinois	United States	62401
209	Illinois CancerCare-Eureka	Eureka	Illinois	United States	61530
210	NorthShore University HealthSystem-Evanston Hospital	Evanston	Illinois	United States	60201
211	Illinois CancerCare-Galesburg	Galesburg	Illinois	United States	61401
212	Western Illinois Cancer Treatment Center	Galesburg	Illinois	United States	61401
213	NorthShore University HealthSystem-Glenbrook Hospital	Glenview	Illinois	United States	60026
214	NorthShore University HealthSystem-Highland Park Hospital	Highland Park	Illinois	United States	60035
215	Duly Health and Care Joliet	Joliet	Illinois	United States	60435
216	Illinois CancerCare-Kewanee Clinic	Kewanee	Illinois	United States	61443
217	Northwestern Medicine Lake Forest Hospital	Lake Forest	Illinois	United States	60045
218	Illinois CancerCare-Macomb	Macomb	Illinois	United States	61455
219	Carle Physician Group-Mattoon/Charleston	Mattoon	Illinois	United States	61938
220	Good Samaritan Regional Health Center	Mount Vernon	Illinois	United States	62864
221	UC Comprehensive Cancer Center at Silver Cross	New Lenox	Illinois	United States	60451
222	Cancer Care Center of O'Fallon	O'Fallon	Illinois	United States	62269
223	University of Chicago Medicine-Orland Park	Orland Park	Illinois	United States	60462
224	Illinois CancerCare-Ottawa Clinic	Ottawa	Illinois	United States	61350
225	Advocate Lutheran General Hospital	Park Ridge	Illinois	United States	60068
226	Illinois CancerCare-Pekin	Pekin	Illinois	United States	61554
227	Illinois CancerCare-Peoria	Peoria	Illinois	United States	61615
228	Methodist Medical Center of Illinois	Peoria	Illinois	United States	61636
229	Illinois CancerCare-Peru	Peru	Illinois	United States	61354
230	Valley Radiation Oncology	Peru	Illinois	United States	61354
231	Illinois CancerCare-Princeton	Princeton	Illinois	United States	61356
232	SwedishAmerican Regional Cancer Center/ACT	Rockford	Illinois	United States	61114
233	Genesis Cancer Center - Silvis	Silvis	Illinois	United States	61282
234	Southern Illinois University School of Medicine	Springfield	Illinois	United States	62702
235	Springfield Clinic	Springfield	Illinois	United States	62702
236	Memorial Medical Center	Springfield	Illinois	United States	62781
237	Southwest Illinois Health Services LLP	Swansea	Illinois	United States	62226
238	Carle Cancer Center	Urbana	Illinois	United States	61801
239	The Carle Foundation Hospital	Urbana	Illinois	United States	61801
240	Illinois CancerCare - Washington	Washington	Illinois	United States	61571
241	Rush-Copley Healthcare Center	Yorkville	Illinois	United States	60560
242	IU Health North Hospital	Carmel	Indiana	United States	46032
243	Indiana University/Melvin and Bren Simon Cancer Center	Indianapolis	Indiana	United States	46202
244	Sidney and Lois Eskenazi Hospital	Indianapolis	Indiana	United States	46202
245	Community Cancer Center East	Indianapolis	Indiana	United States	46219
246	Community Cancer Center South	Indianapolis	Indiana	United States	46227
247	Community Cancer Center North	Indianapolis	Indiana	United States	46256
248	Community Howard Regional Health	Kokomo	Indiana	United States	46904
249	Reid Health	Richmond	Indiana	United States	47374
250	Mary Greeley Medical Center	Ames	Iowa	United States	50010
251	McFarland Clinic PC - Ames	Ames	Iowa	United States	50010
252	McFarland Clinic PC-Boone	Boone	Iowa	United States	50036
253	Saint Anthony Regional Hospital	Carroll	Iowa	United States	51401
254	Mercy Hospital	Cedar Rapids	Iowa	United States	52403
255	Oncology Associates at Mercy Medical Center	Cedar Rapids	Iowa	United States	52403
256	Medical Oncology and Hematology Associates-West Des Moines	Clive	Iowa	United States	50325
257	Mercy Cancer Center-West Lakes	Clive	Iowa	United States	50325
258	Alegent Health Mercy Hospital	Council Bluffs	Iowa	United States	51503
259	Greater Regional Medical Center	Creston	Iowa	United States	50801
260	Genesis Medical Center - East Campus	Davenport	Iowa	United States	52803
261	Genesis Cancer Care Institute	Davenport	Iowa	United States	52804
262	Iowa Cancer Specialists	Davenport	Iowa	United States	52807
263	Iowa Methodist Medical Center	Des Moines	Iowa	United States	50309
264	Medical Oncology and Hematology Associates-Des Moines	Des Moines	Iowa	United States	50309
265	Broadlawns Medical Center	Des Moines	Iowa	United States	50314
266	Medical Oncology and Hematology Associates-Laurel	Des Moines	Iowa	United States	50314
267	Mercy Medical Center - Des Moines	Des Moines	Iowa	United States	50314
268	Iowa Lutheran Hospital	Des Moines	Iowa	United States	50316
269	McFarland Clinic PC-Trinity Cancer Center	Fort Dodge	Iowa	United States	50501
270	Trinity Regional Medical Center	Fort Dodge	Iowa	United States	50501
271	McFarland Clinic PC-Jefferson	Jefferson	Iowa	United States	50129
272	McFarland Clinic PC-Marshalltown	Marshalltown	Iowa	United States	50158
273	Methodist West Hospital	West Des Moines	Iowa	United States	50266-7700
274	Mercy Medical Center-West Lakes	West Des Moines	Iowa	United States	50266
275	Cancer Center of Kansas - Chanute	Chanute	Kansas	United States	66720
276	Cancer Center of Kansas - Dodge City	Dodge City	Kansas	United States	67801
277	Cancer Center of Kansas - El Dorado	El Dorado	Kansas	United States	67042
278	Central Care Cancer Center - Garden City	Garden City	Kansas	United States	67846
279	Central Care Cancer Center - Great Bend	Great Bend	Kansas	United States	67530
280	Cancer Center of Kansas-Independence	Independence	Kansas	United States	67301
281	Cancer Center of Kansas-Kingman	Kingman	Kansas	United States	67068
282	Cancer Center of Kansas-Liberal	Liberal	Kansas	United States	67905
283	Cancer Center of Kansas-Manhattan	Manhattan	Kansas	United States	66502
284	Cancer Center of Kansas - McPherson	McPherson	Kansas	United States	67460
285	Cancer Center of Kansas - Newton	Newton	Kansas	United States	67114
286	Cancer Center of Kansas - Parsons	Parsons	Kansas	United States	67357
287	Cancer Center of Kansas - Pratt	Pratt	Kansas	United States	67124
288	Cancer Center of Kansas - Salina	Salina	Kansas	United States	67401
289	Cancer Center of Kansas - Wellington	Wellington	Kansas	United States	67152
290	Cancer Center of Kansas-Wichita Medical Arts Tower	Wichita	Kansas	United States	67208
291	Ascension Via Christi Hospitals Wichita	Wichita	Kansas	United States	67214
292	Cancer Center of Kansas - Wichita	Wichita	Kansas	United States	67214
293	Cancer Center of Kansas - Winfield	Winfield	Kansas	United States	67156
294	King's Daughter's Medical Center	Ashland	Kentucky	United States	41101
295	Flaget Memorial Hospital	Bardstown	Kentucky	United States	40004
296	Baptist Health Corbin	Corbin	Kentucky	United States	40701
297	Commonwealth Cancer Center-Corbin	Corbin	Kentucky	United States	40701
298	Baptist Health Lexington	Lexington	Kentucky	United States	40503
299	Saint Joseph Radiation Oncology Resource Center	Lexington	Kentucky	United States	40504
300	Saint Joseph Hospital East	Lexington	Kentucky	United States	40509
301	University of Kentucky/Markey Cancer Center	Lexington	Kentucky	United States	40536
302	Saint Joseph London	London	Kentucky	United States	40741
303	Jewish Hospital	Louisville	Kentucky	United States	40202
304	Baptist Health Louisville	Louisville	Kentucky	United States	40207
305	Saints Mary and Elizabeth Hospital	Louisville	Kentucky	United States	40215
306	UofL Health Medical Center Northeast	Louisville	Kentucky	United States	40245
307	Baptist Health Madisonville/Merle Mahr Cancer Center	Madisonville	Kentucky	United States	42431
308	Baptist Health Paducah	Paducah	Kentucky	United States	42003
309	Jewish Hospital Medical Center South	Shepherdsville	Kentucky	United States	40165
310	Ochsner Hematology Oncology North Shore - Covington (West Region)	Covington	Louisiana	United States	70433
311	Louisiana State University Health Science Center	New Orleans	Louisiana	United States	70112
312	University Medical Center New Orleans	New Orleans	Louisiana	United States	70112
313	Ochsner Medical Center Jefferson	New Orleans	Louisiana	United States	70121
314	LSU Health Sciences Center at Shreveport	Shreveport	Louisiana	United States	71103
315	Harold Alfond Center for Cancer Care	Augusta	Maine	United States	04330
316	Waldo County General Hospital	Belfast	Maine	United States	04915
317	MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford	Biddeford	Maine	United States	04005
318	Lafayette Family Cancer Center-EMMC	Brewer	Maine	United States	04412
319	Maine Center for Cancer Medicine-Kennebunk	Kennebunk	Maine	United States	04043
320	Penobscot Bay Medical Center	Rockport	Maine	United States	04856
321	MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford	Sanford	Maine	United States	04073
322	Maine Center for Cancer Medicine-Scarborough	Scarborough	Maine	United States	04074
323	Maine Medical Center- Scarborough Campus	Scarborough	Maine	United States	04074
324	Maine Medical Partners - South Portland	South Portland	Maine	United States	04106
325	Maine Center for Cancer Medicine-Topsham	Topsham	Maine	United States	04086
326	Anne Arundel Medical Center	Annapolis	Maryland	United States	21401
327	Sinai Hospital of Baltimore	Baltimore	Maryland	United States	21215
328	Johns Hopkins University/Sidney Kimmel Cancer Center	Baltimore	Maryland	United States	21287
329	Northwest Hospital Center	Randallstown	Maryland	United States	21133
330	William E Kahlert Regional Cancer Center/Sinai Hospital	Westminster	Maryland	United States	21157
331	Beverly Hospital	Beverly	Massachusetts	United States	01915
332	Tufts Medical Center	Boston	Massachusetts	United States	02111
333	Boston Medical Center	Boston	Massachusetts	United States	02118
334	Beth Israel Deaconess Medical Center	Boston	Massachusetts	United States	02215
335	Dana-Farber Cancer Institute	Boston	Massachusetts	United States	02215
336	Lahey Hospital and Medical Center	Burlington	Massachusetts	United States	01805
337	Addison Gilbert Hospital	Gloucester	Massachusetts	United States	01930
338	Lowell General Hospital	Lowell	Massachusetts	United States	01854
339	Dana-Farber/Brigham and Women's Cancer Center at Milford Regional	Milford	Massachusetts	United States	01757
340	Lahey Medical Center-Peabody	Peabody	Massachusetts	United States	01960
341	Dana-Farber/Brigham and Women's Cancer Center at South Shore	South Weymouth	Massachusetts	United States	02190
342	Baystate Medical Center	Springfield	Massachusetts	United States	01199
343	Winchester Hospital	Winchester	Massachusetts	United States	01890
344	UMass Memorial Medical Center - University Campus	Worcester	Massachusetts	United States	01655
345	University of Michigan Comprehensive Cancer Center	Ann Arbor	Michigan	United States	48109
346	Bronson Battle Creek	Battle Creek	Michigan	United States	49017
347	University of Michigan - Brighton Center for Specialty Care	Brighton	Michigan	United States	48116
348	Wayne State University/Karmanos Cancer Institute	Detroit	Michigan	United States	48201
349	Weisberg Cancer Treatment Center	Farmington Hills	Michigan	United States	48334
350	Helen DeVos Children's Hospital at Spectrum Health	Grand Rapids	Michigan	United States	49503
351	Mercy Health Saint Mary's	Grand Rapids	Michigan	United States	49503
352	Spectrum Health at Butterworth Campus	Grand Rapids	Michigan	United States	49503
353	Bronson Methodist Hospital	Kalamazoo	Michigan	United States	49007
354	West Michigan Cancer Center	Kalamazoo	Michigan	United States	49007
355	Ascension Borgess Cancer Center	Kalamazoo	Michigan	United States	49009
356	Borgess Medical Center	Kalamazoo	Michigan	United States	49048
357	Mercy Health Mercy Campus	Muskegon	Michigan	United States	49444
358	Lakeland Hospital Niles	Niles	Michigan	United States	49120
359	Cancer and Hematology Centers of Western Michigan - Norton Shores	Norton Shores	Michigan	United States	49444
360	Ascension Providence Hospitals - Novi	Novi	Michigan	United States	48374
361	Spectrum Health Reed City Hospital	Reed City	Michigan	United States	49677
362	Lakeland Medical Center Saint Joseph	Saint Joseph	Michigan	United States	49085
363	Marie Yeager Cancer Center	Saint Joseph	Michigan	United States	49085
364	Ascension Providence Hospitals - Southfield	Southfield	Michigan	United States	48075
365	Munson Medical Center	Traverse City	Michigan	United States	49684
366	Metro Health Hospital	Wyoming	Michigan	United States	49519
367	Riverwood Healthcare Center	Aitkin	Minnesota	United States	56431
368	Essentia Health - Baxter Clinic	Baxter	Minnesota	United States	56425
369	Sanford Joe Lueken Cancer Center	Bemidji	Minnesota	United States	56601
370	Essentia Health Saint Joseph's Medical Center	Brainerd	Minnesota	United States	56401
371	Fairview Ridges Hospital	Burnsville	Minnesota	United States	55337
372	Minnesota Oncology - Burnsville	Burnsville	Minnesota	United States	55337
373	Cambridge Medical Center	Cambridge	Minnesota	United States	55008
374	Mercy Hospital	Coon Rapids	Minnesota	United States	55433
375	Essentia Health - Deer River Clinic	Deer River	Minnesota	United States	56636
376	Essentia Health Saint Mary's - Detroit Lakes Clinic	Detroit Lakes	Minnesota	United States	56501
377	Essentia Health Cancer Center	Duluth	Minnesota	United States	55805
378	Essentia Health Saint Mary's Medical Center	Duluth	Minnesota	United States	55805
379	Miller-Dwan Hospital	Duluth	Minnesota	United States	55805
380	Fairview Southdale Hospital	Edina	Minnesota	United States	55435
381	Essentia Health - Ely Clinic	Ely	Minnesota	United States	55731
382	Lake Region Healthcare Corporation-Cancer Care	Fergus Falls	Minnesota	United States	56537
383	Essentia Health - Fosston	Fosston	Minnesota	United States	56542
384	Unity Hospital	Fridley	Minnesota	United States	55432
385	Essentia Health Hibbing Clinic	Hibbing	Minnesota	United States	55746
386	Essentia Health - International Falls Clinic	International Falls	Minnesota	United States	56649
387	Fairview Clinics and Surgery Center Maple Grove	Maple Grove	Minnesota	United States	55369
388	Minnesota Oncology Hematology PA-Maplewood	Maplewood	Minnesota	United States	55109
389	Saint John's Hospital - Healtheast	Maplewood	Minnesota	United States	55109
390	Abbott-Northwestern Hospital	Minneapolis	Minnesota	United States	55407
391	Hennepin County Medical Center	Minneapolis	Minnesota	United States	55415
392	Health Partners Inc	Minneapolis	Minnesota	United States	55454
393	Monticello Cancer Center	Monticello	Minnesota	United States	55362
394	Essentia Health - Moose Lake Clinic	Moose Lake	Minnesota	United States	55767
395	New Ulm Medical Center	New Ulm	Minnesota	United States	56073
396	Essentia Health - Park Rapids	Park Rapids	Minnesota	United States	56470
397	Fairview Northland Medical Center	Princeton	Minnesota	United States	55371
398	North Memorial Medical Health Center	Robbinsdale	Minnesota	United States	55422
399	Mayo Clinic in Rochester	Rochester	Minnesota	United States	55905
400	Coborn Cancer Center at Saint Cloud Hospital	Saint Cloud	Minnesota	United States	56303
401	Park Nicollet Clinic - Saint Louis Park	Saint Louis Park	Minnesota	United States	55416
402	Regions Hospital	Saint Paul	Minnesota	United States	55101
403	United Hospital	Saint Paul	Minnesota	United States	55102
404	Essentia Health Sandstone	Sandstone	Minnesota	United States	55072
405	Saint Francis Regional Medical Center	Shakopee	Minnesota	United States	55379
406	Lakeview Hospital	Stillwater	Minnesota	United States	55082
407	Sanford Thief River Falls Medical Center	Thief River Falls	Minnesota	United States	56701
408	Essentia Health Virginia Clinic	Virginia	Minnesota	United States	55792
409	Ridgeview Medical Center	Waconia	Minnesota	United States	55387
410	Rice Memorial Hospital	Willmar	Minnesota	United States	56201
411	Minnesota Oncology Hematology PA-Woodbury	Woodbury	Minnesota	United States	55125
412	Fairview Lakes Medical Center	Wyoming	Minnesota	United States	55092
413	Baptist Memorial Hospital and Cancer Center-Golden Triangle	Columbus	Mississippi	United States	39705
414	Baptist Cancer Center-Grenada	Grenada	Mississippi	United States	38901
415	University of Mississippi Medical Center	Jackson	Mississippi	United States	39216
416	Baptist Memorial Hospital and Cancer Center-Union County	New Albany	Mississippi	United States	38652
417	Baptist Memorial Hospital and Cancer Center-Oxford	Oxford	Mississippi	United States	38655
418	Singing River Hospital	Pascagoula	Mississippi	United States	39581
419	Baptist Memorial Hospital and Cancer Center-Desoto	Southhaven	Mississippi	United States	38671
420	Saint Louis Cancer and Breast Institute-Ballwin	Ballwin	Missouri	United States	63011
421	Central Care Cancer Center - Bolivar	Bolivar	Missouri	United States	65613
422	Cox Cancer Center Branson	Branson	Missouri	United States	65616
423	Saint Francis Medical Center	Cape Girardeau	Missouri	United States	63703
424	Southeast Cancer Center	Cape Girardeau	Missouri	United States	63703
425	Saint Luke's Hospital	Chesterfield	Missouri	United States	63017
426	University of Missouri - Ellis Fischel	Columbia	Missouri	United States	65212
427	Siteman Cancer Center at West County Hospital	Creve Coeur	Missouri	United States	63141
428	Parkland Health Center - Farmington	Farmington	Missouri	United States	63640
429	Capital Region Southwest Campus	Jefferson City	Missouri	United States	65109
430	Freeman Health System	Joplin	Missouri	United States	64804
431	Mercy Hospital Joplin	Joplin	Missouri	United States	64804
432	Delbert Day Cancer Institute at PCRMC	Rolla	Missouri	United States	65401
433	Mercy Clinic-Rolla-Cancer and Hematology	Rolla	Missouri	United States	65401
434	Heartland Regional Medical Center	Saint Joseph	Missouri	United States	64506
435	Saint Louis Cancer and Breast Institute-South City	Saint Louis	Missouri	United States	63109
436	Washington University School of Medicine	Saint Louis	Missouri	United States	63110
437	Mercy Hospital South	Saint Louis	Missouri	United States	63128
438	Siteman Cancer Center-South County	Saint Louis	Missouri	United States	63129
439	Missouri Baptist Medical Center	Saint Louis	Missouri	United States	63131
440	Siteman Cancer Center at Christian Hospital	Saint Louis	Missouri	United States	63136
441	Mercy Hospital Saint Louis	Saint Louis	Missouri	United States	63141
442	Siteman Cancer Center at Saint Peters Hospital	Saint Peters	Missouri	United States	63376
443	Sainte Genevieve County Memorial Hospital	Sainte Genevieve	Missouri	United States	63670
444	Mercy Hospital Springfield	Springfield	Missouri	United States	65804
445	CoxHealth South Hospital	Springfield	Missouri	United States	65807
446	Missouri Baptist Sullivan Hospital	Sullivan	Missouri	United States	63080
447	Missouri Baptist Outpatient Center-Sunset Hills	Sunset Hills	Missouri	United States	63127
448	Mercy Hospital Washington	Washington	Missouri	United States	63090
449	Community Hospital of Anaconda	Anaconda	Montana	United States	59711
450	Billings Clinic Cancer Center	Billings	Montana	United States	59101
451	Bozeman Deaconess Hospital	Bozeman	Montana	United States	59715
452	Benefis Healthcare- Sletten Cancer Institute	Great Falls	Montana	United States	59405
453	Great Falls Clinic	Great Falls	Montana	United States	59405
454	Kalispell Regional Medical Center	Kalispell	Montana	United States	59901
455	Saint Patrick Hospital - Community Hospital	Missoula	Montana	United States	59802
456	Community Medical Hospital	Missoula	Montana	United States	59804
457	Nebraska Medicine-Bellevue	Bellevue	Nebraska	United States	68123
458	CHI Health Saint Francis	Grand Island	Nebraska	United States	68803
459	CHI Health Good Samaritan	Kearney	Nebraska	United States	68847
460	Saint Elizabeth Regional Medical Center	Lincoln	Nebraska	United States	68510
461	Cancer Partners of Nebraska - Pine Lake	Lincoln	Nebraska	United States	68516
462	Southeast Nebraska Cancer Center - 68th Street Place	Lincoln	Nebraska	United States	68516
463	Nebraska Medicine-Village Pointe	Omaha	Nebraska	United States	68118
464	Alegent Health Immanuel Medical Center	Omaha	Nebraska	United States	68122
465	Alegent Health Bergan Mercy Medical Center	Omaha	Nebraska	United States	68124
466	Alegent Health Lakeside Hospital	Omaha	Nebraska	United States	68130
467	Creighton University Medical Center	Omaha	Nebraska	United States	68131
468	University of Nebraska Medical Center	Omaha	Nebraska	United States	68198
469	Midlands Community Hospital	Papillion	Nebraska	United States	68046
470	Carson Tahoe Regional Medical Center	Carson City	Nevada	United States	89703
471	Cancer and Blood Specialists-Henderson	Henderson	Nevada	United States	89052
472	Comprehensive Cancer Centers of Nevada - Henderson	Henderson	Nevada	United States	89052
473	Comprehensive Cancer Centers of Nevada-Horizon Ridge	Henderson	Nevada	United States	89052
474	Las Vegas Cancer Center-Henderson	Henderson	Nevada	United States	89052
475	OptumCare Cancer Care at Seven Hills	Henderson	Nevada	United States	89052
476	Comprehensive Cancer Centers of Nevada-Southeast Henderson	Henderson	Nevada	United States	89074
477	GenesisCare USA - Henderson	Henderson	Nevada	United States	89074
478	Las Vegas Urology - Green Valley	Henderson	Nevada	United States	89074
479	Las Vegas Urology - Pebble	Henderson	Nevada	United States	89074
480	Urology Specialists of Nevada - Green Valley	Henderson	Nevada	United States	89074
481	Las Vegas Urology - Pecos	Las Vegas	Nevada	United States	89074
482	Desert West Surgery	Las Vegas	Nevada	United States	89102
483	OptumCare Cancer Care at Charleston	Las Vegas	Nevada	United States	89102
484	University Medical Center of Southern Nevada	Las Vegas	Nevada	United States	89102
485	Hope Cancer Care of Nevada	Las Vegas	Nevada	United States	89103
486	Cancer and Blood Specialists-Shadow	Las Vegas	Nevada	United States	89106
487	Radiation Oncology Centers of Nevada Central	Las Vegas	Nevada	United States	89106
488	Urology Specialists of Nevada - Central	Las Vegas	Nevada	United States	89106
489	GenesisCare USA - Las Vegas	Las Vegas	Nevada	United States	89109
490	HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway	Las Vegas	Nevada	United States	89109
491	Sunrise Hospital and Medical Center	Las Vegas	Nevada	United States	89109
492	HealthCare Partners Medical Group Oncology/Hematology-San Martin	Las Vegas	Nevada	United States	89113
493	Las Vegas Prostate Cancer Center	Las Vegas	Nevada	United States	89113
494	Las Vegas Urology - Sunset	Las Vegas	Nevada	United States	89113
495	Urology Specialists of Nevada - Southwest	Las Vegas	Nevada	United States	89113
496	Radiation Oncology Centers of Nevada Southeast	Las Vegas	Nevada	United States	89119
497	Ann M Wierman MD LTD	Las Vegas	Nevada	United States	89128
498	Cancer and Blood Specialists-Tenaya	Las Vegas	Nevada	United States	89128
499	Comprehensive Cancer Centers of Nevada - Northwest	Las Vegas	Nevada	United States	89128
500	GenesisCare USA - Vegas Tenaya	Las Vegas	Nevada	United States	89128
501	HealthCare Partners Medical Group Oncology/Hematology-Tenaya	Las Vegas	Nevada	United States	89128
502	Las Vegas Urology - Cathedral Rock	Las Vegas	Nevada	United States	89128
503	Las Vegas Urology - Smoke Ranch	Las Vegas	Nevada	United States	89128
504	OptumCare Cancer Care at MountainView	Las Vegas	Nevada	United States	89128
505	Urology Specialists of Nevada - Northwest	Las Vegas	Nevada	United States	89128
506	Alliance for Childhood Diseases/Cure 4 the Kids Foundation	Las Vegas	Nevada	United States	89135
507	Comprehensive Cancer Centers of Nevada - Town Center	Las Vegas	Nevada	United States	89144
508	Comprehensive Cancer Centers of Nevada-Summerlin	Las Vegas	Nevada	United States	89144
509	Summerlin Hospital Medical Center	Las Vegas	Nevada	United States	89144
510	Las Vegas Cancer Center-Medical Center	Las Vegas	Nevada	United States	89148-2405
511	Comprehensive Cancer Centers of Nevada	Las Vegas	Nevada	United States	89148
512	GenesisCare USA - Fort Apache	Las Vegas	Nevada	United States	89148
513	OptumCare Cancer Care at Fort Apache	Las Vegas	Nevada	United States	89148
514	HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills	Las Vegas	Nevada	United States	89149
515	Comprehensive Cancer Centers of Nevada - Central Valley	Las Vegas	Nevada	United States	89169
516	University Cancer Center	Las Vegas	Nevada	United States	89169
517	Hope Cancer Care of Nevada-Pahrump	Pahrump	Nevada	United States	89048
518	Renown Regional Medical Center	Reno	Nevada	United States	89502
519	Saint Mary's Regional Medical Center	Reno	Nevada	United States	89503
520	Radiation Oncology Associates	Reno	Nevada	United States	89509
521	New Hampshire Oncology Hematology PA-Concord	Concord	New Hampshire	United States	03301
522	Elliot Hospital	Manchester	New Hampshire	United States	03103
523	Solinsky Center for Cancer Care	Manchester	New Hampshire	United States	03103
524	Memorial Sloan Kettering Basking Ridge	Basking Ridge	New Jersey	United States	07920
525	Trinitas Hospital and Comprehensive Cancer Center - Williamson Street Campus	Elizabeth	New Jersey	United States	07207
526	Hackensack University Medical Center	Hackensack	New Jersey	United States	07601
527	The Cancer Institute of New Jersey Hamilton	Hamilton	New Jersey	United States	08690
528	Jersey City Medical Center	Jersey City	New Jersey	United States	07302
529	Monmouth Medical Center Southern Campus	Lakewood	New Jersey	United States	08701
530	Saint Barnabas Medical Center	Livingston	New Jersey	United States	07039
531	Monmouth Medical Center	Long Branch	New Jersey	United States	07740
532	Memorial Sloan Kettering Monmouth	Middletown	New Jersey	United States	07748
533	Memorial Sloan Kettering Bergen	Montvale	New Jersey	United States	07645
534	Morristown Medical Center	Morristown	New Jersey	United States	07960
535	Inspira Medical Center Mullica Hill	Mullica Hill	New Jersey	United States	08062
536	Rutgers Cancer Institute of New Jersey	New Brunswick	New Jersey	United States	08903
537	Rutgers New Jersey Medical School	Newark	New Jersey	United States	07101
538	Newark Beth Israel Medical Center	Newark	New Jersey	United States	07112
539	Sidney Kimmel Cancer Center Washington Township	Sewell	New Jersey	United States	08080
540	Robert Wood Johnson University Hospital Somerset	Somerville	New Jersey	United States	08876
541	Overlook Hospital	Summit	New Jersey	United States	07902
542	Holy Name Hospital	Teaneck	New Jersey	United States	07666
543	Community Medical Center	Toms River	New Jersey	United States	08755
544	Inspira Medical Center Vineland	Vineland	New Jersey	United States	08360
545	Lovelace Medical Center-Saint Joseph Square	Albuquerque	New Mexico	United States	87102
546	University of New Mexico Cancer Center	Albuquerque	New Mexico	United States	87102
547	Lovelace Women's Hospital	Albuquerque	New Mexico	United States	87109
548	Presbyterian Kaseman Hospital	Albuquerque	New Mexico	United States	87110
549	Memorial Medical Center - Las Cruces	Las Cruces	New Mexico	United States	88011
550	Presbyterian Rust Medical Center/Jorgensen Cancer Center	Rio Rancho	New Mexico	United States	87124
551	Hematology Oncology Associates of Central New York-Auburn	Auburn	New York	United States	13021
552	Montefiore Medical Center-Einstein Campus	Bronx	New York	United States	10461
553	Montefiore Medical Center-Weiler Hospital	Bronx	New York	United States	10461
554	Montefiore Medical Center - Moses Campus	Bronx	New York	United States	10467
555	New York-Presbyterian/Brooklyn Methodist Hospital	Brooklyn	New York	United States	11215
556	Maimonides Medical Center	Brooklyn	New York	United States	11219
557	Roswell Park Cancer Institute	Buffalo	New York	United States	14263
558	Memorial Sloan Kettering Commack	Commack	New York	United States	11725
559	Cancer Institute at Saint Francis Hospital	East Hills	New York	United States	11548
560	Hematology Oncology Associates of Central New York-East Syracuse	East Syracuse	New York	United States	13057
561	The New York Hospital Medical Center of Queens	Flushing	New York	United States	11355
562	Glens Falls Hospital	Glens Falls	New York	United States	12801
563	Memorial Sloan Kettering Westchester	Harrison	New York	United States	10604
564	NYU Winthrop Hospital	Mineola	New York	United States	11501
565	Mount Sinai Chelsea	New York	New York	United States	10011
566	Laura and Isaac Perlmutter Cancer Center at NYU Langone	New York	New York	United States	10016
567	Mount Sinai West	New York	New York	United States	10019
568	Mount Sinai Hospital	New York	New York	United States	10029
569	NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center	New York	New York	United States	10032
570	Memorial Sloan Kettering Cancer Center	New York	New York	United States	10065
571	NYP/Weill Cornell Medical Center	New York	New York	United States	10065
572	Upstate Cancer Center at Oneida	Oneida	New York	United States	13421
573	Upstate Cancer Center at Oswego	Oswego	New York	United States	13126
574	University of Rochester	Rochester	New York	United States	14642
575	Stony Brook University Medical Center	Stony Brook	New York	United States	11794
576	State University of New York Upstate Medical University	Syracuse	New York	United States	13210
577	Hematology Oncology Associates of Central New York-Onondaga Hill	Syracuse	New York	United States	13215
578	Memorial Sloan Kettering Nassau	Uniondale	New York	United States	11553
579	South Nassau Cancer Center	Valley Stream	New York	United States	11580
580	Dickstein Cancer Treatment Center	White Plains	New York	United States	10601
581	Atrium Health Stanly/LCI-Albemarle	Albemarle	North Carolina	United States	28002
582	Rex Hematology Oncology Associates-Cary	Cary	North Carolina	United States	27518
583	UNC Lineberger Comprehensive Cancer Center	Chapel Hill	North Carolina	United States	27599
584	Carolinas Medical Center/Levine Cancer Institute	Charlotte	North Carolina	United States	28203
585	Novant Health Presbyterian Medical Center	Charlotte	North Carolina	United States	28204
586	Novant Health Carolina Surgical - Randolph	Charlotte	North Carolina	United States	28207
587	Atrium Health Pineville/LCI-Pineville	Charlotte	North Carolina	United States	28210
588	Southeastern Medical Oncology Center-Clinton	Clinton	North Carolina	United States	28328
589	Atrium Health Cabarrus/LCI-Concord	Concord	North Carolina	United States	28025
590	Levine Cancer Institute - Rutherford	Forest City	North Carolina	United States	28043
591	Rex Hematology Oncology Associates-Garner	Garner	North Carolina	United States	27529
592	Southeastern Medical Oncology Center-Goldsboro	Goldsboro	North Carolina	United States	27534
593	Novant Health Breast Surgery - Greensboro	Greensboro	North Carolina	United States	27403
594	Margaret R Pardee Memorial Hospital	Hendersonville	North Carolina	United States	28791
595	University of North Carolina-Hillsborough Campus	Hillsborough	North Carolina	United States	27278
596	Novant Health Cancer Institute - Huntersville	Huntersville	North Carolina	United States	28078
597	Novant Health Presbyterian Medical Center Huntersville	Huntersville	North Carolina	United States	28078
598	Southeastern Medical Oncology Center-Jacksonville	Jacksonville	North Carolina	United States	28546
599	Novant Health Cancer Institute - Kernersville	Kernersville	North Carolina	United States	27284
600	Atrium Health Lincoln/LCI-Lincolnton	Lincolnton	North Carolina	United States	28092
601	Levine Cancer Institute - Union West	Matthews	North Carolina	United States	28104
602	Matthews Radiation Oncology Center	Matthews	North Carolina	United States	28105
603	Novant Health Cancer Institute - Matthews	Matthews	North Carolina	United States	28105
604	Atrium Health Union/LCI-Union	Monroe	North Carolina	United States	28112
605	Novant Health Cancer Institute - Mooresville	Mooresville	North Carolina	United States	28117
606	Novant Health Cancer Institute - Mount Airy	Mount Airy	North Carolina	United States	27030
607	FirstHealth of the Carolinas-Moore Regional Hospital	Pinehurst	North Carolina	United States	28374
608	Rex Hematology Oncology Associates-Blue Ridge	Raleigh	North Carolina	United States	27607
609	UNC Rex Cancer Center	Raleigh	North Carolina	United States	27607
610	Rex Cancer Center of Wakefield	Raleigh	North Carolina	United States	27614
611	Novant Health Cancer Institute - Rowan	Salisbury	North Carolina	United States	28144
612	Rowan Regional Medical Center	Salisbury	North Carolina	United States	28144
613	Atrium Health Cleveland/LCI-Cleveland	Shelby	North Carolina	United States	28150
614	Novant Health Cancer Institute - Statesville	Statesville	North Carolina	United States	28625
615	Novant Health Cancer Institute - Thomasville	Thomasville	North Carolina	United States	27360
616	Novant Health Cancer Institute - Wilkesboro	Wilkesboro	North Carolina	United States	28659
617	Novant Health Forsyth Medical Center	Winston-Salem	North Carolina	United States	27103
618	Sanford Bismarck Medical Center	Bismarck	North Dakota	United States	58501
619	Essentia Health Cancer Center-South University Clinic	Fargo	North Dakota	United States	58103
620	Sanford South University Medical Center	Fargo	North Dakota	United States	58103
621	Southpointe-Sanford Medical Center Fargo	Fargo	North Dakota	United States	58103
622	Sanford Medical Center Fargo	Fargo	North Dakota	United States	58104
623	Sanford Broadway Medical Center	Fargo	North Dakota	United States	58122
624	Sanford Roger Maris Cancer Center	Fargo	North Dakota	United States	58122
625	Essentia Health - Jamestown Clinic	Jamestown	North Dakota	United States	58401
626	Aultman Alliance Community Hospital	Alliance	Ohio	United States	44601
627	Indu and Raj Soin Medical Center	Beavercreek	Ohio	United States	45431
628	Saint Elizabeth Boardman Hospital	Boardman	Ohio	United States	44512
629	Aultman Health Foundation	Canton	Ohio	United States	44710
630	Dayton Physicians LLC-Miami Valley South	Centerville	Ohio	United States	45459
631	Miami Valley Hospital South	Centerville	Ohio	United States	45459
632	The Christ Hospital	Cincinnati	Ohio	United States	45219
633	Good Samaritan Hospital - Cincinnati	Cincinnati	Ohio	United States	45220
634	Oncology Hematology Care Inc-Kenwood	Cincinnati	Ohio	United States	45236
635	Bethesda North Hospital	Cincinnati	Ohio	United States	45242
636	TriHealth Cancer Institute-Westside	Cincinnati	Ohio	United States	45247
637	TriHealth Cancer Institute-Anderson	Cincinnati	Ohio	United States	45255
638	MetroHealth Medical Center	Cleveland	Ohio	United States	44109
639	Ohio State University Comprehensive Cancer Center	Columbus	Ohio	United States	43210
640	Miami Valley Hospital	Dayton	Ohio	United States	45409
641	Dayton Physician LLC-Miami Valley Hospital North	Dayton	Ohio	United States	45415
642	Miami Valley Hospital North	Dayton	Ohio	United States	45415
643	Armes Family Cancer Center	Findlay	Ohio	United States	45840
644	Blanchard Valley Hospital	Findlay	Ohio	United States	45840
645	Orion Cancer Care	Findlay	Ohio	United States	45840
646	Atrium Medical Center-Middletown Regional Hospital	Franklin	Ohio	United States	45005-1066
647	Dayton Physicians LLC-Atrium	Franklin	Ohio	United States	45005
648	Dayton Physicians LLC-Wayne	Greenville	Ohio	United States	45331
649	Wayne Hospital	Greenville	Ohio	United States	45331
650	Greater Dayton Cancer Center	Kettering	Ohio	United States	45409
651	First Dayton Cancer Care	Kettering	Ohio	United States	45420
652	Kettering Medical Center	Kettering	Ohio	United States	45429
653	Springfield Regional Cancer Center	Springfield	Ohio	United States	45504
654	Springfield Regional Medical Center	Springfield	Ohio	United States	45505
655	Trinity's Tony Teramana Cancer Center	Steubenville	Ohio	United States	43952
656	Dayton Physicians LLC-Upper Valley	Troy	Ohio	United States	45373
657	Upper Valley Medical Center	Troy	Ohio	United States	45373
658	Saint Joseph Warren Hospital	Warren	Ohio	United States	44484
659	Wright-Patterson Medical Center	Wright-Patterson Air Force Base	Ohio	United States	45433
660	Saint Elizabeth Youngstown Hospital	Youngstown	Ohio	United States	44501
661	Cancer Centers of Southwest Oklahoma Research	Lawton	Oklahoma	United States	73505
662	University of Oklahoma Health Sciences Center	Oklahoma City	Oklahoma	United States	73104
663	Mercy Hospital Oklahoma City	Oklahoma City	Oklahoma	United States	73120
664	Saint Alphonsus Medical Center-Baker City	Baker City	Oregon	United States	97814
665	Saint Charles Health System	Bend	Oregon	United States	97701
666	Clackamas Radiation Oncology Center	Clackamas	Oregon	United States	97015
667	Providence Cancer Institute Clackamas Clinic	Clackamas	Oregon	United States	97015
668	Bay Area Hospital	Coos Bay	Oregon	United States	97420
669	Providence Newberg Medical Center	Newberg	Oregon	United States	97132
670	Saint Alphonsus Medical Center-Ontario	Ontario	Oregon	United States	97914
671	Providence Portland Medical Center	Portland	Oregon	United States	97213
672	Providence Saint Vincent Medical Center	Portland	Oregon	United States	97225
673	Saint Charles Health System-Redmond	Redmond	Oregon	United States	97756
674	UPMC Altoona	Altoona	Pennsylvania	United States	16601
675	UPMC-Heritage Valley Health System Beaver	Beaver	Pennsylvania	United States	15009
676	Bryn Mawr Hospital	Bryn Mawr	Pennsylvania	United States	19010
677	UPMC Hillman Cancer Center at Butler Health System	Butler	Pennsylvania	United States	16001
678	UPMC Camp Hill	Camp Hill	Pennsylvania	United States	17011
679	Carlisle Regional Cancer Center	Carlisle	Pennsylvania	United States	17015
680	Christiana Care Health System-Concord Health Center	Chadds Ford	Pennsylvania	United States	19317
681	Chambersburg Hospital	Chambersburg	Pennsylvania	United States	17201
682	WellSpan Medical Oncology and Hematology	Chambersburg	Pennsylvania	United States	17201
683	Main Line Health Center-Collegeville	Collegeville	Pennsylvania	United States	19426
684	UPMC Hillman Cancer Center - Passavant - Cranberry	Cranberry Township	Pennsylvania	United States	16066
685	Geisinger Medical Center	Danville	Pennsylvania	United States	17822
686	Fox Chase Cancer Center - East Norriton Hospital Outpatient Center	East Norriton	Pennsylvania	United States	19401
687	Ephrata Cancer Center	Ephrata	Pennsylvania	United States	17522
688	UPMC Hillman Cancer Center Erie	Erie	Pennsylvania	United States	16505
689	Saint Vincent Hospital	Erie	Pennsylvania	United States	16544
690	Main Line Health Center-Exton	Exton	Pennsylvania	United States	19341
691	UPMC Cancer Center at UPMC Horizon	Farrell	Pennsylvania	United States	16121
692	Adams Cancer Center	Gettysburg	Pennsylvania	United States	17325
693	UPMC Cancer Centers - Arnold Palmer Pavilion	Greensburg	Pennsylvania	United States	15601
694	Oncology Hematology Associates	Greenville	Pennsylvania	United States	16125
695	Cherry Tree Cancer Center	Hanover	Pennsylvania	United States	17331
696	UPMC Pinnacle Harrisburg	Harrisburg	Pennsylvania	United States	17101
697	UPMC Pinnacle Cancer Center/Community Osteopathic Campus	Harrisburg	Pennsylvania	United States	17109
698	Geisinger Medical Center-Cancer Center Hazleton	Hazleton	Pennsylvania	United States	18201
699	Penn State Milton S Hershey Medical Center	Hershey	Pennsylvania	United States	17033-0850
700	IRMC Cancer Center	Indiana	Pennsylvania	United States	15701
701	Jefferson Hospital	Jefferson Hills	Pennsylvania	United States	15025
702	UPMC-Johnstown/John P. Murtha Regional Cancer Center	Johnstown	Pennsylvania	United States	15901
703	Sechler Family Cancer Center	Lebanon	Pennsylvania	United States	17042
704	Geisinger Medical Oncology-Lewisburg	Lewisburg	Pennsylvania	United States	17837
705	Lewistown Hospital	Lewistown	Pennsylvania	United States	17044
706	UPMC Cancer Center at UPMC McKeesport	McKeesport	Pennsylvania	United States	15132
707	UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion	Mechanicsburg	Pennsylvania	United States	17050
708	Riddle Memorial Hospital	Media	Pennsylvania	United States	19063
709	Forbes Hospital	Monroeville	Pennsylvania	United States	15146
710	UPMC Hillman Cancer Center - Monroeville	Monroeville	Pennsylvania	United States	15146
711	UPMC-Coraopolis/Heritage Valley Radiation Oncology	Moon	Pennsylvania	United States	15108
712	UPMC Hillman Cancer Center - Part of Frick Hospital	Mount Pleasant	Pennsylvania	United States	15666
713	Arnold Palmer Cancer Center Medical Oncology Norwin	N. Huntingdon	Pennsylvania	United States	15642
714	UPMC Cancer Center-Natrona Heights	Natrona Heights	Pennsylvania	United States	15065
715	UPMC Hillman Cancer Center - New Castle	New Castle	Pennsylvania	United States	16105
716	Bryn Mawr Health Center	Newtown Square	Pennsylvania	United States	19073
717	Paoli Memorial Hospital	Paoli	Pennsylvania	United States	19301
718	University of Pennsylvania/Abramson Cancer Center	Philadelphia	Pennsylvania	United States	19104
719	Thomas Jefferson University Hospital	Philadelphia	Pennsylvania	United States	19107
720	Fox Chase Cancer Center	Philadelphia	Pennsylvania	United States	19111
721	Jefferson Torresdale Hospital	Philadelphia	Pennsylvania	United States	19114
722	Temple University Hospital	Philadelphia	Pennsylvania	United States	19140
723	Jefferson Methodist Hospital	Philadelphia	Pennsylvania	United States	19148
724	Allegheny General Hospital	Pittsburgh	Pennsylvania	United States	15212
725	UPMC-Magee Womens Hospital	Pittsburgh	Pennsylvania	United States	15213
726	Oncology Hematology Association	Pittsburgh	Pennsylvania	United States	15215
727	UPMC-Saint Margaret	Pittsburgh	Pennsylvania	United States	15215
728	UPMC-Mercy Hospital	Pittsburgh	Pennsylvania	United States	15219
729	West Penn Hospital	Pittsburgh	Pennsylvania	United States	15224
730	University of Pittsburgh Cancer Institute (UPCI)	Pittsburgh	Pennsylvania	United States	15232
731	UPMC-Passavant Hospital	Pittsburgh	Pennsylvania	United States	15237
732	UPMC-Saint Clair Hospital Cancer Center	Pittsburgh	Pennsylvania	United States	15243
733	Geisinger Cancer Services-Pottsville	Pottsville	Pennsylvania	United States	17901
734	Penn State Health Saint Joseph Medical Center	Reading	Pennsylvania	United States	19605
735	Community Medical Center	Scranton	Pennsylvania	United States	18510
736	Geisinger Medical Oncology-Selinsgrove	Selinsgrove	Pennsylvania	United States	17870
737	UPMC Cancer Center at UPMC Northwest	Seneca	Pennsylvania	United States	16346
738	Geisinger Medical Group	State College	Pennsylvania	United States	16801
739	UPMC Cancer Center-Uniontown	Uniontown	Pennsylvania	United States	15401
740	UPMC Uniontown Hospital Radiation Oncology	Uniontown	Pennsylvania	United States	15401
741	UPMC Cancer Center-Washington	Washington	Pennsylvania	United States	15301
742	UPMC Washington Hospital Radiation Oncology	Washington	Pennsylvania	United States	15301
743	Chester County Hospital	West Chester	Pennsylvania	United States	19380
744	UPMC West Mifflin-Cancer Center Jefferson	West Mifflin	Pennsylvania	United States	15122
745	Reading Hospital	West Reading	Pennsylvania	United States	19611
746	Wexford Health and Wellness Pavilion	Wexford	Pennsylvania	United States	15090
747	Geisinger Wyoming Valley/Henry Cancer Center	Wilkes-Barre	Pennsylvania	United States	18711
748	Divine Providence Hospital	Williamsport	Pennsylvania	United States	17754
749	Asplundh Cancer Pavilion	Willow Grove	Pennsylvania	United States	19090
750	Lankenau Medical Center	Wynnewood	Pennsylvania	United States	19096
751	Cancer Care Associates of York	York	Pennsylvania	United States	17403
752	WellSpan Health-York Cancer Center	York	Pennsylvania	United States	17403
753	WellSpan Health-York Hospital	York	Pennsylvania	United States	17403
754	UPMC Memorial	York	Pennsylvania	United States	17408
755	Women and Infants Hospital	Providence	Rhode Island	United States	02905
756	Kent Hospital	Warwick	Rhode Island	United States	02886
757	Smilow Cancer Hospital Care Center - Westerly	Westerly	Rhode Island	United States	02891
758	Saint Joseph's/Candler - Bluffton Campus	Bluffton	South Carolina	United States	29910
759	Saint Francis Hospital	Greenville	South Carolina	United States	29601
760	Saint Francis Cancer Center	Greenville	South Carolina	United States	29607
761	South Carolina Cancer Specialists PC	Hilton Head Island	South Carolina	United States	29926-3827
762	Levine Cancer Institute-Rock Hill	Rock Hill	South Carolina	United States	29732
763	Avera Cancer Institute-Aberdeen	Aberdeen	South Dakota	United States	57401
764	Avera Cancer Institute	Sioux Falls	South Dakota	United States	57105
765	Bristol Regional Medical Center	Bristol	Tennessee	United States	37620
766	Baptist Memorial Hospital and Cancer Center-Collierville	Collierville	Tennessee	United States	38017
767	Vanderbilt-Ingram Cancer Center Cool Springs	Franklin	Tennessee	United States	37067
768	Ballad Health Cancer Care - Kingsport	Kingsport	Tennessee	United States	37660
769	Wellmont Holston Valley Hospital and Medical Center	Kingsport	Tennessee	United States	37660
770	Baptist Memorial Hospital and Cancer Center-Memphis	Memphis	Tennessee	United States	38120
771	Vanderbilt Breast Center at One Hundred Oaks	Nashville	Tennessee	United States	37204
772	Vanderbilt University/Ingram Cancer Center	Nashville	Tennessee	United States	37232
773	Saint Joseph Regional Cancer Center	Bryan	Texas	United States	77802
774	Parkland Memorial Hospital	Dallas	Texas	United States	75235
775	UT Southwestern/Simmons Cancer Center-Dallas	Dallas	Texas	United States	75390
776	Tarrant County Hospital District/JPS Health Network	Fort Worth	Texas	United States	76104
777	UT Southwestern/Simmons Cancer Center-Fort Worth	Fort Worth	Texas	United States	76104
778	Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center	Houston	Texas	United States	77030
779	Ben Taub General Hospital	Houston	Texas	United States	77030
780	Doctor's Hospital of Laredo	Laredo	Texas	United States	78041
781	UT Southwestern Clinical Center at Richardson/Plano	Richardson	Texas	United States	75080
782	Farmington Health Center	Farmington	Utah	United States	84025
783	University of Utah Sugarhouse Health Center	Salt Lake City	Utah	United States	84106
784	Huntsman Cancer Institute/University of Utah	Salt Lake City	Utah	United States	84112
785	South Jordan Health Center	South Jordan	Utah	United States	84009
786	Wellmont Medical Associates-Bristol	Bristol	Virginia	United States	24201
787	Cancer Specialists of Tidewater Limited	Chesapeake	Virginia	United States	23320
788	Peninsula Cancer Institute-Gloucester	Gloucester	Virginia	United States	23061
789	Bon Secours Memorial Regional Medical Center	Mechanicsville	Virginia	United States	23116
790	Bon Secours Westchester Emergency Center	Midlothian	Virginia	United States	23113
791	Bon Secours Saint Francis Medical Center	Midlothian	Virginia	United States	23114
792	Peninsula Cancer Institute-Newport News	Newport News	Virginia	United States	23601
793	Bon Secours DePaul Medical Center	Norfolk	Virginia	United States	23505
794	Southwest VA Regional Cancer Center	Norton	Virginia	United States	24273
795	Bon Secours Maryview Medical Center	Portsmouth	Virginia	United States	23707
796	Bon Secours Saint Mary's Hospital	Richmond	Virginia	United States	23226
797	Bon Secours Cancer Institute at Reynolds Crossing	Richmond	Virginia	United States	23230
798	VCU Massey Cancer Center at Stony Point	Richmond	Virginia	United States	23235
799	Virginia Commonwealth University/Massey Cancer Center	Richmond	Virginia	United States	23298
800	VCU Community Memorial Health Center	South Hill	Virginia	United States	23970
801	Bon Secours Health Center at Harbour View	Suffolk	Virginia	United States	23435
802	Cancer Specialists of Tidewater-Suffolk	Suffolk	Virginia	United States	23435
803	Peninsula Cancer Institute-Cancer Specialists of Tidewater	Virginia Beach	Virginia	United States	23454
804	Peninsula Cancer Institute-Williamsburg	Williamsburg	Virginia	United States	23185
805	Providence Regional Cancer System-Aberdeen	Aberdeen	Washington	United States	98520
806	Overlake Medical Center	Bellevue	Washington	United States	98004
807	PeaceHealth Saint Joseph Medical Center	Bellingham	Washington	United States	98225
808	Harrison HealthPartners Hematology and Oncology-Bremerton	Bremerton	Washington	United States	98310
809	Harrison Medical Center	Bremerton	Washington	United States	98310
810	Highline Medical Center-Main Campus	Burien	Washington	United States	98166
811	Providence Regional Cancer System-Centralia	Centralia	Washington	United States	98531
812	Swedish Cancer Institute-Edmonds	Edmonds	Washington	United States	98026
813	Saint Elizabeth Hospital	Enumclaw	Washington	United States	98022
814	Providence Regional Cancer Partnership	Everett	Washington	United States	98201
815	Saint Francis Hospital	Federal Way	Washington	United States	98003
816	Swedish Cancer Institute-Issaquah	Issaquah	Washington	United States	98029
817	Kadlec Clinic Hematology and Oncology	Kennewick	Washington	United States	99336
818	Providence Regional Cancer System-Lacey	Lacey	Washington	United States	98503
819	Saint Clare Hospital	Lakewood	Washington	United States	98499
820	PeaceHealth Saint John Medical Center	Longview	Washington	United States	98632
821	Jefferson Healthcare	Port Townsend	Washington	United States	98368
822	Harrison HealthPartners Hematology and Oncology-Poulsbo	Poulsbo	Washington	United States	98370
823	Valley Medical Center	Renton	Washington	United States	98055
824	Pacific Gynecology Specialists	Seattle	Washington	United States	98104
825	Swedish Medical Center-Ballard Campus	Seattle	Washington	United States	98107
826	Swedish Medical Center-First Hill	Seattle	Washington	United States	98122-4307
827	Swedish Medical Center-Cherry Hill	Seattle	Washington	United States	98122-5711
828	PeaceHealth United General Medical Center	Sedro-Woolley	Washington	United States	98284
829	Providence Regional Cancer System-Shelton	Shelton	Washington	United States	98584
830	Franciscan Research Center-Northwest Medical Plaza	Tacoma	Washington	United States	98405
831	Northwest Medical Specialties PLLC	Tacoma	Washington	United States	98405
832	PeaceHealth Southwest Medical Center	Vancouver	Washington	United States	98664
833	Providence Saint Mary Regional Cancer Center	Walla Walla	Washington	United States	99362
834	North Star Lodge Cancer Center at Yakima Valley Memorial Hospital	Yakima	Washington	United States	98902
835	Providence Regional Cancer System-Yelm	Yelm	Washington	United States	98597
836	West Virginia University Charleston Division	Charleston	West Virginia	United States	25304
837	Langlade Hospital and Cancer Center	Antigo	Wisconsin	United States	54409
838	ThedaCare Regional Cancer Center	Appleton	Wisconsin	United States	54911
839	Ascension Saint Elizabeth Hospital	Appleton	Wisconsin	United States	54915
840	Duluth Clinic Ashland	Ashland	Wisconsin	United States	54806
841	Northwest Wisconsin Cancer Center	Ashland	Wisconsin	United States	54806
842	ThedaCare Cancer Care - Berlin	Berlin	Wisconsin	United States	54923
843	Ascension Southeast Wisconsin Hospital - Elmbrook Campus	Brookfield	Wisconsin	United States	53045
844	Aurora Cancer Care-Southern Lakes VLCC	Burlington	Wisconsin	United States	53105
845	Ascension Calumet Hospital	Chilton	Wisconsin	United States	53014
846	Marshfield Clinic-Chippewa Center	Chippewa Falls	Wisconsin	United States	54729
847	Aurora Saint Luke's South Shore	Cudahy	Wisconsin	United States	53110
848	HSHS Sacred Heart Hospital	Eau Claire	Wisconsin	United States	54701
849	Marshfield Medical Center-EC Cancer Center	Eau Claire	Wisconsin	United States	54701
850	Mayo Clinic Health System-Eau Claire Clinic	Eau Claire	Wisconsin	United States	54701
851	Mayo Clinic Health System Eau Claire Hospital-Luther Campus	Eau Claire	Wisconsin	United States	54703
852	Ascension Saint Francis - Reiman Cancer Center	Franklin	Wisconsin	United States	53132
853	Ascension Southeast Wisconsin Hospital - Franklin	Franklin	Wisconsin	United States	53132
854	Aurora Health Care Germantown Health Center	Germantown	Wisconsin	United States	53022
855	Aurora Cancer Care-Grafton	Grafton	Wisconsin	United States	53024
856	Saint Vincent Hospital Cancer Center Green Bay	Green Bay	Wisconsin	United States	54301
857	Saint Vincent Hospital Cancer Center at Saint Mary's	Green Bay	Wisconsin	United States	54303
858	Aurora BayCare Medical Center	Green Bay	Wisconsin	United States	54311
859	Essentia Health-Hayward Clinic	Hayward	Wisconsin	United States	54843
860	UW Cancer Center Johnson Creek	Johnson Creek	Wisconsin	United States	53038
861	Aurora Cancer Care-Kenosha South	Kenosha	Wisconsin	United States	53142
862	Gundersen Lutheran Medical Center	La Crosse	Wisconsin	United States	54601
863	Mayo Clinic Health System-Franciscan Healthcare	La Crosse	Wisconsin	United States	54601
864	Marshfield Clinic - Ladysmith Center	Ladysmith	Wisconsin	United States	54848
865	University of Wisconsin Carbone Cancer Center	Madison	Wisconsin	United States	53792
866	Aurora Bay Area Medical Group-Marinette	Marinette	Wisconsin	United States	54143
867	Marshfield Medical Center-Marshfield	Marshfield	Wisconsin	United States	54449
868	Aspirus Medford Hospital	Medford	Wisconsin	United States	54451
869	Ascension Columbia Saint Mary's Hospital Ozaukee	Mequon	Wisconsin	United States	53097
870	Aurora Cancer Care-Milwaukee	Milwaukee	Wisconsin	United States	53209
871	Ascension Southeast Wisconsin Hospital - Saint Joseph Campus	Milwaukee	Wisconsin	United States	53210
872	Ascension Columbia Saint Mary's Hospital - Milwaukee	Milwaukee	Wisconsin	United States	53211
873	Ascension Saint Francis Hospital	Milwaukee	Wisconsin	United States	53215
874	Aurora Saint Luke's Medical Center	Milwaukee	Wisconsin	United States	53215
875	Aurora Sinai Medical Center	Milwaukee	Wisconsin	United States	53233
876	Marshfield Clinic-Minocqua Center	Minocqua	Wisconsin	United States	54548
877	ThedaCare Regional Medical Center - Neenah	Neenah	Wisconsin	United States	54956
878	Cancer Center of Western Wisconsin	New Richmond	Wisconsin	United States	54017
879	Saint Vincent Hospital Cancer Center at Oconto Falls	Oconto Falls	Wisconsin	United States	54154
880	Ascension Mercy Hospital	Oshkosh	Wisconsin	United States	54904
881	Vince Lombardi Cancer Clinic - Oshkosh	Oshkosh	Wisconsin	United States	54904
882	Ascension All Saints Hospital	Racine	Wisconsin	United States	53405
883	Aurora Cancer Care-Racine	Racine	Wisconsin	United States	53406
884	Ascension Saint Mary's Hospital	Rhinelander	Wisconsin	United States	54501
885	Marshfield Medical Center-Rice Lake	Rice Lake	Wisconsin	United States	54868
886	Vince Lombardi Cancer Clinic-Sheboygan	Sheboygan	Wisconsin	United States	53081
887	Essentia Health-Spooner Clinic	Spooner	Wisconsin	United States	54801
888	Ascension Saint Michael's Hospital	Stevens Point	Wisconsin	United States	54481
889	Marshfield Medical Center-River Region at Stevens Point	Stevens Point	Wisconsin	United States	54482
890	Saint Vincent Hospital Cancer Center at Sturgeon Bay	Sturgeon Bay	Wisconsin	United States	54235-1495
891	Aurora Medical Center in Summit	Summit	Wisconsin	United States	53066
892	Essentia Health Saint Mary's Hospital - Superior	Superior	Wisconsin	United States	54880
893	Vince Lombardi Cancer Clinic-Two Rivers	Two Rivers	Wisconsin	United States	54241
894	Aspirus Regional Cancer Center	Wausau	Wisconsin	United States	54401
895	Marshfield Clinic-Wausau Center	Wausau	Wisconsin	United States	54401
896	Ascension Medical Group Southeast Wisconsin - Mayfair Road	Wauwatosa	Wisconsin	United States	53226
897	Aurora Cancer Care-Milwaukee West	Wauwatosa	Wisconsin	United States	53226
898	Aurora West Allis Medical Center	West Allis	Wisconsin	United States	53227
899	Marshfield Medical Center - Weston	Weston	Wisconsin	United States	54476
900	Aspirus Cancer Care - Wisconsin Rapids	Wisconsin Rapids	Wisconsin	United States	54494
901	Marshfield Clinic - Wisconsin Rapids Center	Wisconsin Rapids	Wisconsin	United States	54494
902	Cheyenne Regional Medical Center-West	Cheyenne	Wyoming	United States	82001
903	Billings Clinic-Cody	Cody	Wyoming	United States	82414
904	Welch Cancer Center	Sheridan	Wyoming	United States	82801
905	Cancer Center-Metro Medical Center Bayamon	Bayamon		Puerto Rico	00959-5060
906	HIMA San Pablo Oncologic Hospital	Caguas		Puerto Rico	00726
907	Doctors Cancer Center	Manati		Puerto Rico	00674
908	Instituto Oncologia Moderna Ponce	Ponce		Puerto Rico	00716
909	San Juan Community Oncology Group	San Juan		Puerto Rico	00917
910	Primary Care Physician Group	San Juan		Puerto Rico	00920
911	Centro Comprensivo de Cancer de UPR	San Juan		Puerto Rico	00927
912	San Juan City Hospital	San Juan		Puerto Rico	00936

Sponsors and Collaborators

• ECOG-ACRIN Cancer Research Group
• National Cancer Institute (NCI)

Investigators

• Principal Investigator: Nadine M Tung, ECOG-ACRIN Cancer Research Group

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: ECOG-ACRIN Cancer Research Group
• ClinicalTrials.gov Identifier: NCT04266249
• Other Study ID Numbers: EA1181; NCI-2019-07439; EA1181; EA1181; U10CA180820
• First Posted: Feb 12, 2020
• Last Update Posted: Aug 25, 2022
• Last Verified: Aug 1, 2022

• Studies a U.S. FDA-regulated Drug Product: No
• Studies a U.S. FDA-regulated Device Product: No
• Additional relevant MeSH terms: Breast Neoplasms; Paclitaxel; Maytansine; Docetaxel; Ado-Trastuzumab Emtansine; Albumin-Bound Paclitaxel; Trastuzumab; Pertuzumab; Trastuzumab biosimilar HLX02; Antineoplastic Agents, Immunological; Antibodies; Immunoglobulins; Antibodies, Monoclonal; Immunoconjugates

Study Results

No Results Posted as of Aug 25, 2022