Ibrutinib and Rituximab Compared With Fludarabine Phosphate, Cyclophosphamide, and Rituximab in Treating Patients With Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

• Sponsor: National Cancer Institute (NCI) (NIH)
• Overall Status: Active, not recruiting
• CT.gov ID: NCT02048813
• Collaborator: (none)
• Enrollment: 519
• Locations: 796
• Arms: 2
• Anticipated Duration (Months): 147.6
• Patients Per Site: 0.7
• Patients Per Site Per Month: 0

Study Details

Study Description

Brief Summary

This phase III trial studies ibrutinib and rituximab to see how well they work compared to fludarabine phosphate, cyclophosphamide, and rituximab in treating patients with untreated chronic lymphocytic leukemia or small lymphocytic lymphoma. Ibrutinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Chemotherapy drugs, such as fludarabine phosphate and cyclophosphamide, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Rituximab is a monoclonal antibody. It binds to a protein called CD20, which is found on B cells (a type of white blood cell) and some types of cancer cells. This may help the immune system kill cancer cells. It is not yet known whether fludarabine phosphate, cyclophosphamide, and rituximab may work better than ibrutinib and rituximab in treating patients with untreated chronic lymphocytic leukemia or small lymphocytic lymphoma.

Condition or Disease	Intervention/Treatment	Phase
Anemia; Chronic Lymphocytic Leukemia; Small Lymphocytic Lymphoma	Drug: Cyclophosphamide; Drug: Fludarabine Phosphate; Drug: Ibrutinib; Other: Laboratory Biomarker Analysis; Other: Pharmacogenomic Study; Other: Quality-of-Life Assessment; Biological: Rituximab	Phase 3

Detailed Description

PRIMARY OBJECTIVE:

1. To evaluate the ability of ibrutinib-based induction therapy to prolong progression free survival (PFS) compared to standard fludarabine phosphate, cyclophosphamide, and rituximab (FCR) chemoimmunotherapy for younger patients with chronic lymphocytic leukemia (CLL).

SECONDARY OBJECTIVES:

1. Evaluate overall survival (OS) of patients based on treatment arm. II. Monitor and assess toxicity of treatment with ibrutinib-based induction relative to standard FCR chemotherapy.

2. To compare quality of life (QOL) in CLL patients during the first 6 months of treatment among patients receiving ibrutinib-based induction therapy relative to standard FCR chemoimmunotherapy.

3. To compare QOL over the long-term in CLL patients receiving continuous therapy using ibrutinib to that of CLL patients who completed FCR therapy.

4. Determine the effect of pretreatment clinical and biological characteristics (e.g. disease stage, immunoglobulin heavy chain variable region gene [IGHV] mutation status, fluorescent in situ hybridization [FISH]) on clinical outcomes (e.g. complete response, PFS) of the different arms.

5. Determine if the minimal residual disease (MRD) status as assessed by flow cytometry at different time points during and after treatment is an effective surrogate marker for prolonged PFS and overall survival.

6. Compare the genetic abnormalities and dynamics of intra-clonal architecture of CLL patients before and after treatment with chemoimmunotherapy (CIT) and non-CIT approaches and explore relationships with treatment resistance.

7. Explore the effects of FCR and ibrutinib-based therapy on T-cell immune function.

8. Conduct confirmatory validation genotyping of single nucleotide polymorphisms (SNPs) associated with the efficacy and toxicity of fludarabine-based therapy as in a prior Eastern Cooperative Oncology Group (ECOG) genome-wide association study (GWAS) analysis in the E2997 trial.

9. Evaluate the ability of prognostic model that incorporates clinical and biologic characters to predict a response to therapy and clinical outcome (PFS, OS).

10. Evaluate signaling networks downstream of the B-cell receptor in patients receiving ibrutinib-based therapy.

11. Collect relapse samples to study mechanisms of resistance to both FCR and ibrutinib-based therapy.

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

ARM A: Patients receive ibrutinib orally (PO) once daily (QD) on days 1-28. Beginning cycle 2, patients also receive rituximab intravenously (IV) over 4 hours on days 1 and 2 of cycle 2, and day 1 of cycles 3-7. Treatment repeats every 28 days for 7 cycles in the absence of unacceptable toxicity. In the absence of disease progression, patients may continue ibrutinib PO QD.

ARM B: Patients receive rituximab IV over 4 hours on days 1 and 2 of cycle 1, and day 1 of cycles 2-6. Patients also receive fludarabine phosphate IV over 30 minutes and cyclophosphamide IV over 30 minutes on days 1-3. Treatment repeats every 28 days for 6 cycles in the absence of unacceptable toxicity.

After completion of study treatment, patients are followed up for 10 years.

Study Design

• Study Type: Interventional
• Anticipated Enrollment: 519 participants
• Allocation: Randomized
• Intervention Model: Parallel Assignment
• Masking: None (Open Label)
• Primary Purpose: Treatment
• Official Title: A Randomized Phase III Study of Ibrutinib (PCI-32765)-Based Therapy vs Standard Fludarabine, Cyclophosphamide, and Rituximab (FCR) Chemoimmunotherapy in Untreated Younger Patients With Chronic Lymphocytic Leukemia (CLL)
• Actual Study Start Date: Feb 20, 2014
• Anticipated Primary Completion Date: Jun 9, 2026
• Anticipated Study Completion Date: Jun 9, 2026

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Arm A (ibrutinib, rituximab) Patients receive ibrutinib PO QD on days 1-28. Beginning cycle 2, patients also receive rituximab IV over 4 hours on days 1 and 2 of cycle 2, and day 1 of cycles 3-7. Treatment repeats every 28 days for 7 cycles in the absence of unacceptable toxicity. In the absence of disease progression, patients may continue ibrutinib PO QD.	Drug: Ibrutinib; Given PO; Other Names: BTK Inhibitor PCI-32765 CRA-032765 Imbruvica PCI-32765 ; Other: Laboratory Biomarker Analysis; Correlative studies; Other: Pharmacogenomic Study; Correlative studies; Other Names: PHARMACOGENOMIC ; Other: Quality-of-Life Assessment; Ancillary studies; Other Names: Quality of Life Assessment ; Biological: Rituximab; Given IV; Other Names: ABP 798 BI 695500 C2B8 Monoclonal Antibody Chimeric Anti-CD20 Antibody CT-P10 IDEC-102 IDEC-C2B8 IDEC-C2B8 Monoclonal Antibody MabThera Monoclonal Antibody IDEC-C2B8 PF-05280586 Riabni Rituxan Rituximab ABBS Rituximab ARRX Rituximab Biosimilar ABP 798 Rituximab Biosimilar BI 695500 Rituximab Biosimilar CT-P10 Rituximab Biosimilar GB241 Rituximab Biosimilar IBI301 Rituximab Biosimilar JHL1101 Rituximab Biosimilar PF-05280586 Rituximab Biosimilar RTXM83 Rituximab Biosimilar SAIT101 Rituximab Biosimilar SIBP-02 rituximab biosimilar TQB2303 Rituximab PVVR rituximab-abbs Rituximab-arrx Rituximab-pvvr RTXM83 Ruxience Truxima
Active Comparator: Arm B (rituximab, fludarabine phosphate, cyclophosphamide) Patients receive rituximab IV over 4 hours on days 1 and 2 of cycle 1, and day 1 of cycles 2-6. Patients also receive fludarabine phosphate IV over 30 minutes and cyclophosphamide IV over 30 minutes on days 1-3. Treatment repeats every 28 days for 6 cycles in the absence of unacceptable toxicity.	Drug: Cyclophosphamide; Given IV; Other Names: (-)-Cyclophosphamide 2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate Carloxan Ciclofosfamida Ciclofosfamide Cicloxal Clafen Claphene CP monohydrate CTX CYCLO-cell Cycloblastin Cycloblastine Cyclophospham Cyclophosphamid monohydrate Cyclophosphamide Monohydrate Cyclophosphamidum Cyclophosphan Cyclophosphane Cyclophosphanum Cyclostin Cyclostine Cytophosphan Cytophosphane Cytoxan Fosfaseron Genoxal Genuxal Ledoxina Mitoxan Neosar Revimmune Syklofosfamid WR- 138719 ; Drug: Fludarabine Phosphate; Given IV; Other Names: 2-F-ara-AMP 9H-Purin-6-amine, 2-fluoro-9-(5-O-phosphono-.beta.-D-arabinofuranosyl)- Beneflur Fludara SH T 586 ; Other: Laboratory Biomarker Analysis; Correlative studies; Other: Pharmacogenomic Study; Correlative studies; Other Names: PHARMACOGENOMIC ; Other: Quality-of-Life Assessment; Ancillary studies; Other Names: Quality of Life Assessment ; Biological: Rituximab; Given IV; Other Names: ABP 798 BI 695500 C2B8 Monoclonal Antibody Chimeric Anti-CD20 Antibody CT-P10 IDEC-102 IDEC-C2B8 IDEC-C2B8 Monoclonal Antibody MabThera Monoclonal Antibody IDEC-C2B8 PF-05280586 Riabni Rituxan Rituximab ABBS Rituximab ARRX Rituximab Biosimilar ABP 798 Rituximab Biosimilar BI 695500 Rituximab Biosimilar CT-P10 Rituximab Biosimilar GB241 Rituximab Biosimilar IBI301 Rituximab Biosimilar JHL1101 Rituximab Biosimilar PF-05280586 Rituximab Biosimilar RTXM83 Rituximab Biosimilar SAIT101 Rituximab Biosimilar SIBP-02 rituximab biosimilar TQB2303 Rituximab PVVR rituximab-abbs Rituximab-arrx Rituximab-pvvr RTXM83 Ruxience Truxima

Outcome Measures

Primary Outcome Measures

1. Progression free survival (PFS) [The time from randomization to progression or to death without documentation of progression, assessed up to 10 years]

   A stratified logrank test applied to all patients as randomized will be the primary analysis, with age, Eastern Cooperative Oncology Group (ECOG) performance status, disease stage, and baseline cytogenetic abnormalities as stratification factors. The same analysis applied to eligible patients only will also be performed as a sensitivity analysis. Cox proportional hazards models will be used to assess possible effects of clinical and biological characteristics on outcome, including age, gender, disease stage, cytogenetic abnormalities, ECOG performance status, and important mutations.

2. Change in quality of life [Baseline to 12 months after beginning therapy]

   Will be assessed using Functional Assessment of Cancer Therapy -Leukemia (FACT-Leu) Trial Outcome Index (TOI).

Secondary Outcome Measures

1. Overall survival (OS) [Time from randomization until death due to any cause, assessed up to 10 years]

   A stratified logrank test applied to all patients as randomized will be the primary analysis for OS, with age, ECOG performance status, disease stage, and baseline cytogenetic abnormalities as stratification factors. The same analysis applied to eligible patients only will also be performed as a sensitivity analysis. Cox proportional hazards models will be used to assess possible effects of clinical and biological characteristics on outcome, including age, gender, disease stage, cytogenetic abnormalities, ECOG performance status, and important mutations.

2. Incidence of toxicity, defined as adverse events that are classified as either possibly, probably, or definitely related to study treatment, graded according to the National Cancer Institute (NCI) Common Terminology for Adverse Events version 4.0 [Up to 10 years]

   The maximum grade for each type of toxicity will be recorded for each patient, and frequency tables will be reviewed to determine toxicity patterns. In addition, all adverse event data that is graded as 3, 4, or 5 will be reviewed and classified as either "unrelated or unlikely to be related" to study treatment in the event of an actual relationship developing. Effective April 1, 2018 adverse event reporting will use Common Terminology for Adverse Events (CTCAE) version 5.0.

3. Change in FACT-Leu TOI score [Baseline to 3 months after beginning therapy]

   The change in FACT-Leu TOI score will be compared between arm A and arm B to assess the short-term effect of the two therapies on quality of life (QOL).

4. Change in FACT-Leu TOI score [Baseline to 6 months after beginning therapy]

   The change in FACT-Leu TOI score from the time of randomization to 6 months after beginning therapy will be compared between the two treatment arms in order to provide additional information regarding the toxicity of the different regimens.

5. Impact of chronic lymphocytic leukemia (CLL) on QOL [Baseline]

   The social well-being and emotional well-being components of the FACT-General (G) will be administered at study entry. The entire FACT-Leukemia instrument (FACT-G and the leukemia subscale) at baseline will be analyzed using descriptive statistics to assess the impact of CLL on QOL independent of treatment.

6. Adherence to prescription assessed by the Moriskey Adherence Scale (Arm A only) [Up to 24 months]

   Descriptive statistics will be used to summarize trend in adherence to prescription.

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years to 70 Years
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Inclusion Criteria:

• Diagnosis of CLL according to the National Cancer Institute (NCI)/Internal Workshop on Chronic Lymphocytic Leukemia (IWCLL) criteria or small lymphocytic lymphoma (SLL) according to the World Health Organization (WHO) criteria; this includes previous documentation of:

• Biopsy-proven small lymphocytic lymphoma or

• Diagnosis of CLL according to the NCI/IWCLL criteria as evidenced by all of the following:

• Peripheral blood lymphocyte count of greater than 5 x 10^9/L

• Immunophenotype consistent with CLL defined as:

• The predominant population of lymphocytes share both B-cell antigens (cluster of differentiation [CD]19, CD20 [typically dim expression], or CD23) as well as CD5 in the absence of other pan-T-cell markers (CD3, CD2, etc)

• Clonality as evidenced by kappa or lambda light chain restriction (typically dim immunoglobulin expression)

• Negative FISH analysis for t(11;14)(immunoglobulin heavy locus [IgH]/cyclin D1 [CCND1]) on peripheral blood or tissue biopsy (e.g. marrow aspirate) or negative immunohistochemical stains for cyclin D1 staining on involved tissue biopsy (e.g. marrow aspirate or lymph node biopsy)

• No prior chemotherapy, Bruton's tyrosine kinase (BTK) inhibitor therapy, or monoclonal anti-body therapy for treatment of CLL or SLL

• Has met at least one of the following indications for treatment:

• Evidence of progressive marrow failure as manifested by the development of worsening anemia (hemoglobin [Hg] < 11 g/dl) and/or thrombocytopenia (platelets < 100 x 10^9/L)

• Symptomatic or progressive lymphadenopathy, splenomegaly, or hepatomegaly

• One or more of the following disease-related symptoms:

• Weight loss >= 10% within the previous 6 months

• Grade 2 or 3 fatigue attributed to CLL

• Fevers > 100.5 Fahrenheit (F) for 2 weeks without evidence of infection

• Clinically significant night sweats without evidence of infection

• Progressive lymphocytosis (not due to the effects of corticosteroids) with an increase of > 50% over a two-month period or an anticipated doubling time of less than six months

• ECOG performance status between 0-2

• Life expectancy of >= 12 months

• Ability to tolerate FCR based therapy

• No deletion of 17p13 on cytogenetic analysis by FISH

• Glomerular filtration rate (GFR) > 40 mL/minute as calculated by the Cockcroft-Gault formula (obtained =< 14 days prior to registration)

• Total bilirubin =< 2.5 x upper limit of normal (ULN) (obtained =< 14 days prior to registration) unless due to Gilbert's disease; for those with a total bilirubin > 2.5 x ULN, a direct bilirubin should be performed and must be < 1.5 mg/dL for Gilbert's to be diagnosed

• If value is higher due to hepatic involvement by CLL, patient is eligible

• Serum glutamic oxaloacetic transaminase (SGOT) (aspartate transaminase [AST])/serum glutamate-pyruvate transaminase (SGPT) (alanine transaminase [ALT]) =< 3.0 x the institutional ULN (obtained =< 14 days prior to registration)

• If value is higher due to hepatic involvement by CLL, patient is eligible

• Prothrombin time (PT)/international normalized ratio (INR) < 1.5 ULN and partial thromboplastin time (PTT) (activated partial thromboplastin time [aPTT]) < 1.5 X ULN (obtained =< 14 days prior to registration)

• If value is higher due to hepatic involvement by CLL, patient is eligible

• No active hemolytic anemia requiring immunosuppressive therapy or other pharmacologic treatment; patients who have a positive Coombs test but no evidence of hemolysis are NOT excluded from participation

• No current use of corticosteroids; EXCEPTION: low doses of steroids (< 10 mg of prednisone or equivalent dose of other steroid) used for treatment of non-hematologic medical condition (e.g. chronic adrenal insufficiency) is permitted

• No previous use of corticosteroids for autoimmune complications that have developed since the initial diagnosis of CLL; prior use of corticosteroids for reasons other than treatment of autoimmune complications is allowed

• No other active primary malignancy (other than non-melanomatous skin cancer or carcinoma in situ of the cervix) requiring treatment or limiting expected survival to =< 2 years; NOTE: if there is a history of prior malignancy, they must not be receiving other specific treatment (other than hormonal therapy for their cancer)

• Able to adhere to the study visit schedule and other protocol requirements

• No major surgery within the last 4 weeks (28 days) of first dose of study drug or minor surgery within 3 days of first dose of study drug

• No radiation therapy =< 4 weeks prior to registration

• Patients with human immunodeficiency virus (HIV) infection may be eligible provided they meet the following criteria:

• CD4-positive cell count >= lower limit of institutional normal

• HIV viral load < 10,000 copies HIV ribonucleic acid (RNA)/mL (if not on anti-HIV therapy) OR < 50 copies HIV RNA/mL (if on anti-HIV therapy)

• No evidence of hepatitis B or C infection

• No evidence of resistant strains of HIV

• No history of acquired immune deficiency syndrome (AIDS)-defining condition

• Patients must not have any of the following conditions:

• Congestive heart failure or New York Heart Association Functional Classification III or IV congestive heart failure

• History of myocardial infarction, unstable angina, or acute coronary syndrome within 6 months prior to registration

• Recent infections requiring systemic treatment; need to have completed anti-biotic therapy > 14 days before the first dose of study drug

• Cerebral vascular accident or intracranial bleed within the last 6 months

• Infection with known chronic, active hepatitis C

• Serologic status reflecting active hepatitis B or C infection; patients that are positive for hepatitis B core antibody, hepatitis B surface antigen (HBsAg), or hepatitis C antibody must have a negative polymerase chain reaction (PCR) prior to enrollment (PCR positive patients will be excluded)

• Patients are not eligible if they require treatment with a strong cytochrome P450 (CYP) family 3, subfamily A (3A) inhibitor

• Patients may not be on any other investigational agents

• Patients may not have received warfarin or another vitamin K antagonist in the preceding 30 days

• Women must not be pregnant or breast-feeding since this study involves an investigational agent whose genotoxic, mutagenic, and teratogenic effects on the developing fetus and newborn are unknown; female patients of childbearing potential must have a negative serum pregnancy test within 2 weeks prior to registration to rule out pregnancy; female patients who are of non-reproductive potential are those who are post-menopausal by history (i.e. no menses for >= 1 year); OR history of hysterectomy; OR history of bilateral tubal ligation; OR history of bilateral oophorectomy)

• Women of childbearing potential and sexually active males must be strongly advised to use an accepted and effective method of contraception or to abstain from sexual intercourse for 90 days after the last dose of study drug

• Patient must be able to swallow capsules and not have the following conditions:

• Disease significantly affecting gastrointestinal function

• Resection of the stomach or small bowel

• Symptomatic inflammatory bowel disease

• Ulcerative colitis

• Partial or complete bowel obstruction

• Patient must not be on any other systemic immunosuppressant therapy other than corticosteroids within 28 days of the first dose of study drug

• Patient must not be vaccinated with live, attenuated vaccines within 4 weeks of first dose of study drug

• Patient must not have any known bleeding disorders (e.g., von Willebrand's disease) or hemophilia

• Patient must not have currently active, clinically significant hepatic impairment (>= moderate hepatic impairment according to the NCI/Child Pugh)

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	University of Alabama at Birmingham Cancer Center	Birmingham	Alabama	United States	35233
2	Anchorage Associates in Radiation Medicine	Anchorage	Alaska	United States	98508
3	Anchorage Radiation Therapy Center	Anchorage	Alaska	United States	99504
4	Alaska Breast Care and Surgery LLC	Anchorage	Alaska	United States	99508
5	Alaska Oncology and Hematology LLC	Anchorage	Alaska	United States	99508
6	Alaska Regional Hospital	Anchorage	Alaska	United States	99508
7	Alaska Women's Cancer Care	Anchorage	Alaska	United States	99508
8	Anchorage Oncology Centre	Anchorage	Alaska	United States	99508
9	Katmai Oncology Group	Anchorage	Alaska	United States	99508
10	Providence Alaska Medical Center	Anchorage	Alaska	United States	99508
11	Fairbanks Memorial Hospital	Fairbanks	Alaska	United States	99701
12	Mayo Clinic in Arizona	Scottsdale	Arizona	United States	85259
13	CHI Saint Vincent Cancer Center Hot Springs	Hot Springs	Arkansas	United States	71913
14	NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro	Jonesboro	Arkansas	United States	72401
15	University of Arkansas for Medical Sciences	Little Rock	Arkansas	United States	72205
16	Kaiser Permanente-Anaheim	Anaheim	California	United States	92806
17	Kaiser Permanente-Deer Valley Medical Center	Antioch	California	United States	94531
18	PCR Oncology	Arroyo Grande	California	United States	93420
19	Sutter Auburn Faith Hospital	Auburn	California	United States	95602
20	Sutter Cancer Centers Radiation Oncology Services-Auburn	Auburn	California	United States	95603
21	Kaiser Permanente-Baldwin Park	Baldwin Park	California	United States	91706
22	Kaiser Permanente-Bellflower	Bellflower	California	United States	90706
23	Alta Bates Summit Medical Center-Herrick Campus	Berkeley	California	United States	94704
24	Providence Saint Joseph Medical Center/Disney Family Cancer Center	Burbank	California	United States	91505
25	Mills-Peninsula Medical Center	Burlingame	California	United States	94010
26	Sutter Cancer Centers Radiation Oncology Services-Cameron Park	Cameron Park	California	United States	95682
27	Eden Hospital Medical Center	Castro Valley	California	United States	94546
28	Adventist Health Cancer Care Center Chico	Chico	California	United States	95973
29	John Muir Medical Center-Concord Campus	Concord	California	United States	94520
30	Sutter Davis Hospital	Davis	California	United States	95616
31	Kaiser Permanente-Fontana	Fontana	California	United States	92335
32	Kaiser Permanente-Fremont	Fremont	California	United States	94538
33	Kaiser Permanente-Fresno	Fresno	California	United States	93720
34	Marin Cancer Care Inc	Greenbrae	California	United States	94904
35	Marin General Hospital	Greenbrae	California	United States	94904
36	Kaiser Permanente - Harbor City	Harbor City	California	United States	90710
37	Kaiser Permanente-Irvine	Irvine	California	United States	92618
38	Kaiser Permanente Los Angeles Medical Center	Los Angeles	California	United States	90027
39	Kaiser Permanente West Los Angeles	Los Angeles	California	United States	90034
40	Memorial Medical Center	Modesto	California	United States	95355
41	Kaiser Permanente-Modesto	Modesto	California	United States	95356
42	Palo Alto Medical Foundation-Camino Division	Mountain View	California	United States	94040
43	Palo Alto Medical Foundation-Gynecologic Oncology	Mountain View	California	United States	94040
44	Sutter Cancer Research Consortium	Novato	California	United States	94945
45	Kaiser Permanente-Oakland	Oakland	California	United States	94611
46	UC Irvine Health/Chao Family Comprehensive Cancer Center	Orange	California	United States	92868
47	Palo Alto Medical Foundation Health Care	Palo Alto	California	United States	94301
48	Stanford Cancer Institute Palo Alto	Palo Alto	California	United States	94304
49	Kaiser Permanente - Panorama City	Panorama City	California	United States	91402
50	Kaiser Permanente-Redwood City	Redwood City	California	United States	94063
51	Kaiser Permanente-Richmond	Richmond	California	United States	94801
52	Kaiser Permanente-Riverside	Riverside	California	United States	92505
53	Kaiser Permanente-Roseville	Roseville	California	United States	95661
54	Sutter Cancer Centers Radiation Oncology Services-Roseville	Roseville	California	United States	95661
55	Sutter Roseville Medical Center	Roseville	California	United States	95661
56	Sutter Medical Center Sacramento	Sacramento	California	United States	95816
57	Kaiser Permanente-South Sacramento	Sacramento	California	United States	95823
58	Kaiser Permanente - Sacramento	Sacramento	California	United States	95825
59	Kaiser Permanente-San Diego Mission	San Diego	California	United States	92108
60	Kaiser Permanente-San Diego Zion	San Diego	California	United States	92120
61	California Pacific Medical Center-Pacific Campus	San Francisco	California	United States	94115
62	Kaiser Permanente-San Francisco	San Francisco	California	United States	94115
63	Kaiser Permanente-Santa Teresa-San Jose	San Jose	California	United States	95119
64	Stanford Cancer Center South Bay	San Jose	California	United States	95124
65	Kaiser Permanente San Leandro	San Leandro	California	United States	94577
66	Pacific Central Coast Health Center-San Luis Obispo	San Luis Obispo	California	United States	93401
67	Kaiser Permanente-San Marcos	San Marcos	California	United States	92078
68	Kaiser Permanente-San Rafael	San Rafael	California	United States	94903
69	Kaiser Permanente Medical Center - Santa Clara	Santa Clara	California	United States	95051
70	Palo Alto Medical Foundation-Santa Cruz	Santa Cruz	California	United States	95065
71	Kaiser Permanente-Santa Rosa	Santa Rosa	California	United States	95403
72	Sutter Pacific Medical Foundation	Santa Rosa	California	United States	95403
73	Kaiser Permanente-South San Francisco	South San Francisco	California	United States	94080
74	Kaiser Permanente-Stockton	Stockton	California	United States	95210
75	Palo Alto Medical Foundation-Sunnyvale	Sunnyvale	California	United States	94086
76	Sutter Cancer Centers Radiation Oncology Services-Vacaville	Vacaville	California	United States	95687
77	Kaiser Permanente Medical Center-Vacaville	Vacaville	California	United States	95688
78	Kaiser Permanente-Vallejo	Vallejo	California	United States	94589
79	Sutter Solano Medical Center/Cancer Center	Vallejo	California	United States	94589
80	Kaiser Permanente-Walnut Creek	Walnut Creek	California	United States	94596
81	John Muir Medical Center-Walnut Creek	Walnut Creek	California	United States	94598
82	Kaiser Permanente-Woodland Hills	Woodland Hills	California	United States	91367
83	Rocky Mountain Cancer Centers-Aurora	Aurora	Colorado	United States	80012
84	The Medical Center of Aurora	Aurora	Colorado	United States	80012
85	Boulder Community Hospital	Boulder	Colorado	United States	80301
86	Rocky Mountain Cancer Centers-Boulder	Boulder	Colorado	United States	80304
87	Penrose-Saint Francis Healthcare	Colorado Springs	Colorado	United States	80907
88	Rocky Mountain Cancer Centers-Penrose	Colorado Springs	Colorado	United States	80907
89	Denver Health Medical Center	Denver	Colorado	United States	80204
90	Kaiser Permanente-Franklin	Denver	Colorado	United States	80205
91	National Jewish Health-Main Campus	Denver	Colorado	United States	80206
92	Porter Adventist Hospital	Denver	Colorado	United States	80210
93	Colorado Blood Cancer Institute	Denver	Colorado	United States	80218
94	Presbyterian - Saint Lukes Medical Center - Health One	Denver	Colorado	United States	80218
95	Rocky Mountain Cancer Centers-Midtown	Denver	Colorado	United States	80218
96	SCL Health Saint Joseph Hospital	Denver	Colorado	United States	80218
97	Rocky Mountain Cancer Centers-Rose	Denver	Colorado	United States	80220
98	Rose Medical Center	Denver	Colorado	United States	80220
99	Western States Cancer Research NCORP	Denver	Colorado	United States	80222
100	Mercy Medical Center	Durango	Colorado	United States	81301
101	Southwest Oncology PC	Durango	Colorado	United States	81301
102	Mountain Blue Cancer Care Center - Swedish	Englewood	Colorado	United States	80113
103	Swedish Medical Center	Englewood	Colorado	United States	80113
104	Mountain Blue Cancer Care Center	Golden	Colorado	United States	80401
105	National Jewish Health-Western Hematology Oncology	Golden	Colorado	United States	80401
106	North Colorado Medical Center	Greeley	Colorado	United States	80631
107	Rocky Mountain Cancer Centers-Greenwood Village	Greenwood Village	Colorado	United States	80111
108	Kaiser Permanente-Rock Creek	Lafayette	Colorado	United States	80026
109	Rocky Mountain Cancer Centers-Lakewood	Lakewood	Colorado	United States	80228
110	Saint Anthony Hospital	Lakewood	Colorado	United States	80228
111	Rocky Mountain Cancer Centers-Littleton	Littleton	Colorado	United States	80120
112	Littleton Adventist Hospital	Littleton	Colorado	United States	80122
113	Kaiser Permanente-Lone Tree	Lone Tree	Colorado	United States	80124
114	Rocky Mountain Cancer Centers-Sky Ridge	Lone Tree	Colorado	United States	80124
115	Sky Ridge Medical Center	Lone Tree	Colorado	United States	80124
116	Longmont United Hospital	Longmont	Colorado	United States	80501
117	Rocky Mountain Cancer Centers-Longmont	Longmont	Colorado	United States	80501
118	McKee Medical Center	Loveland	Colorado	United States	80539
119	Parker Adventist Hospital	Parker	Colorado	United States	80138
120	Rocky Mountain Cancer Centers-Parker	Parker	Colorado	United States	80138
121	Saint Mary Corwin Medical Center	Pueblo	Colorado	United States	81004
122	Rocky Mountain Cancer Centers - Pueblo	Pueblo	Colorado	United States	81008
123	Rocky Mountain Cancer Centers-Thornton	Thornton	Colorado	United States	80260
124	SCL Health Lutheran Medical Center	Wheat Ridge	Colorado	United States	80033
125	Smilow Cancer Hospital-Derby Care Center	Derby	Connecticut	United States	06418
126	Smilow Cancer Hospital Care Center-Fairfield	Fairfield	Connecticut	United States	06824
127	Smilow Cancer Hospital Care Center at Saint Francis	Hartford	Connecticut	United States	06105
128	Middlesex Hospital	Middletown	Connecticut	United States	06457
129	Smilow Cancer Center/Yale-New Haven Hospital	New Haven	Connecticut	United States	06510
130	Yale University	New Haven	Connecticut	United States	06520
131	Yale-New Haven Hospital North Haven Medical Center	North Haven	Connecticut	United States	06473
132	Smilow Cancer Hospital-Orange Care Center	Orange	Connecticut	United States	06477
133	Smilow Cancer Hospital-Torrington Care Center	Torrington	Connecticut	United States	06790
134	Smilow Cancer Hospital Care Center-Trumbull	Trumbull	Connecticut	United States	06611
135	Smilow Cancer Hospital-Waterbury Care Center	Waterbury	Connecticut	United States	06708
136	Beebe Medical Center	Lewes	Delaware	United States	19958
137	Christiana Gynecologic Oncology LLC	Newark	Delaware	United States	19713
138	Delaware Clinical and Laboratory Physicians PA	Newark	Delaware	United States	19713
139	Helen F Graham Cancer Center	Newark	Delaware	United States	19713
140	Medical Oncology Hematology Consultants PA	Newark	Delaware	United States	19713
141	Christiana Care Health System-Christiana Hospital	Newark	Delaware	United States	19718
142	Beebe Health Campus	Rehoboth Beach	Delaware	United States	19971
143	TidalHealth Nanticoke / Allen Cancer Center	Seaford	Delaware	United States	19973
144	Christiana Care Health System-Wilmington Hospital	Wilmington	Delaware	United States	19801
145	Baptist MD Anderson Cancer Center	Jacksonville	Florida	United States	32207
146	Lakeland Regional Health Hollis Cancer Center	Lakeland	Florida	United States	33805
147	Orlando Health Cancer Institute	Orlando	Florida	United States	32806
148	Phoebe Putney Memorial Hospital	Albany	Georgia	United States	31701
149	Emory University Hospital/Winship Cancer Institute	Atlanta	Georgia	United States	30322
150	John B Amos Cancer Center	Columbus	Georgia	United States	31904
151	Central Georgia Gynecologic Oncology	Macon	Georgia	United States	31201
152	Medical Center of Central Georgia	Macon	Georgia	United States	31201
153	Lewis Cancer and Research Pavilion at Saint Joseph's/Candler	Savannah	Georgia	United States	31405
154	Kaiser Permanente Moanalua Medical Center	Honolulu	Hawaii	United States	96819
155	Saint Alphonsus Cancer Care Center-Boise	Boise	Idaho	United States	83706
156	Saint Luke's Cancer Institute - Boise	Boise	Idaho	United States	83712
157	Kootenai Health - Coeur d'Alene	Coeur d'Alene	Idaho	United States	83814
158	Saint Luke's Cancer Institute - Fruitland	Fruitland	Idaho	United States	83619
159	Saint Luke's Cancer Institute - Meridian	Meridian	Idaho	United States	83642
160	Saint Luke's Cancer Institute - Nampa	Nampa	Idaho	United States	83686
161	Kootenai Clinic Cancer Services - Post Falls	Post Falls	Idaho	United States	83854
162	Kootenai Cancer Clinic	Sandpoint	Idaho	United States	83864
163	Saint Luke's Cancer Institute - Twin Falls	Twin Falls	Idaho	United States	83301
164	Rush - Copley Medical Center	Aurora	Illinois	United States	60504
165	Saint Joseph Medical Center	Bloomington	Illinois	United States	61701
166	Illinois CancerCare-Bloomington	Bloomington	Illinois	United States	61704
167	Illinois CancerCare-Canton	Canton	Illinois	United States	61520
168	Memorial Hospital of Carbondale	Carbondale	Illinois	United States	62902
169	Illinois CancerCare-Carthage	Carthage	Illinois	United States	62321
170	Centralia Oncology Clinic	Centralia	Illinois	United States	62801
171	Northwestern University	Chicago	Illinois	United States	60611
172	University of Chicago Comprehensive Cancer Center	Chicago	Illinois	United States	60637
173	Carle on Vermilion	Danville	Illinois	United States	61832
174	Cancer Care Specialists of Illinois - Decatur	Decatur	Illinois	United States	62526
175	Decatur Memorial Hospital	Decatur	Illinois	United States	62526
176	Carle Physician Group-Effingham	Effingham	Illinois	United States	62401
177	Crossroads Cancer Center	Effingham	Illinois	United States	62401
178	AMITA Health Alexian Brothers Medical Center	Elk Grove Village	Illinois	United States	60007
179	Illinois CancerCare-Eureka	Eureka	Illinois	United States	61530
180	NorthShore University HealthSystem-Evanston Hospital	Evanston	Illinois	United States	60201
181	Illinois CancerCare-Galesburg	Galesburg	Illinois	United States	61401
182	Western Illinois Cancer Treatment Center	Galesburg	Illinois	United States	61401
183	Northwestern Medicine Cancer Center Delnor	Geneva	Illinois	United States	60134
184	NorthShore University HealthSystem-Glenbrook Hospital	Glenview	Illinois	United States	60026
185	Hematology Oncology Associates of Illinois-Highland Park	Highland Park	Illinois	United States	60035
186	NorthShore University HealthSystem-Highland Park Hospital	Highland Park	Illinois	United States	60035
187	Duly Health and Care Joliet	Joliet	Illinois	United States	60435
188	Presence Saint Mary's Hospital	Kankakee	Illinois	United States	60901
189	Illinois CancerCare-Kewanee Clinic	Kewanee	Illinois	United States	61443
190	AMG Libertyville - Oncology	Libertyville	Illinois	United States	60048
191	Illinois CancerCare-Macomb	Macomb	Illinois	United States	61455
192	Carle Physician Group-Mattoon/Charleston	Mattoon	Illinois	United States	61938
193	Loyola University Medical Center	Maywood	Illinois	United States	60153
194	Trinity Medical Center	Moline	Illinois	United States	61265
195	Good Samaritan Regional Health Center	Mount Vernon	Illinois	United States	62864
196	UC Comprehensive Cancer Center at Silver Cross	New Lenox	Illinois	United States	60451
197	Illinois Cancer Specialists-Niles	Niles	Illinois	United States	60714
198	Carle Cancer Institute Normal	Normal	Illinois	United States	61761
199	Cancer Care Center of O'Fallon	O'Fallon	Illinois	United States	62269
200	Advocate Christ Medical Center	Oak Lawn	Illinois	United States	60453-2699
201	Illinois CancerCare-Ottawa Clinic	Ottawa	Illinois	United States	61350
202	Radiation Oncology of Northern Illinois	Ottawa	Illinois	United States	61350
203	Illinois CancerCare-Pekin	Pekin	Illinois	United States	61554
204	OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center	Pekin	Illinois	United States	61554
205	Illinois CancerCare-Peoria	Peoria	Illinois	United States	61615
206	OSF Saint Francis Radiation Oncology at Peoria Cancer Center	Peoria	Illinois	United States	61615
207	Methodist Medical Center of Illinois	Peoria	Illinois	United States	61636
208	OSF Saint Francis Medical Center	Peoria	Illinois	United States	61637
209	Illinois CancerCare-Peru	Peru	Illinois	United States	61354
210	Valley Radiation Oncology	Peru	Illinois	United States	61354
211	Illinois CancerCare-Princeton	Princeton	Illinois	United States	61356
212	SwedishAmerican Regional Cancer Center/ACT	Rockford	Illinois	United States	61114
213	Hematology Oncology Associates of Illinois - Skokie	Skokie	Illinois	United States	60076
214	North Shore Medical Center	Skokie	Illinois	United States	60076
215	Central Illinois Hematology Oncology Center	Springfield	Illinois	United States	62702
216	Southern Illinois University School of Medicine	Springfield	Illinois	United States	62702
217	Springfield Clinic	Springfield	Illinois	United States	62702
218	Memorial Medical Center	Springfield	Illinois	United States	62781
219	Carle Cancer Center	Urbana	Illinois	United States	61801
220	The Carle Foundation Hospital	Urbana	Illinois	United States	61801
221	Northwestern Medicine Cancer Center Warrenville	Warrenville	Illinois	United States	60555
222	Rush-Copley Healthcare Center	Yorkville	Illinois	United States	60560
223	Saint Vincent Anderson Regional Hospital/Cancer Center	Anderson	Indiana	United States	46016
224	Franciscan Saint Anthony Health-Michigan City	Michigan City	Indiana	United States	46360
225	Woodland Cancer Care Center	Michigan City	Indiana	United States	46360
226	Memorial Regional Cancer Center Day Road	Mishawaka	Indiana	United States	46545
227	Reid Health	Richmond	Indiana	United States	47374
228	Memorial Hospital of South Bend	South Bend	Indiana	United States	46601
229	Mary Greeley Medical Center	Ames	Iowa	United States	50010
230	McFarland Clinic PC - Ames	Ames	Iowa	United States	50010
231	McFarland Clinic PC-Boone	Boone	Iowa	United States	50036
232	Medical Oncology and Hematology Associates-West Des Moines	Clive	Iowa	United States	50325
233	Mercy Cancer Center-West Lakes	Clive	Iowa	United States	50325
234	Alegent Health Mercy Hospital	Council Bluffs	Iowa	United States	51503
235	Greater Regional Medical Center	Creston	Iowa	United States	50801
236	Medical Oncology and Hematology Associates-Laurel	Des Moines	Iowa	United States	50314
237	Mercy Medical Center - Des Moines	Des Moines	Iowa	United States	50314
238	McFarland Clinic PC-Trinity Cancer Center	Fort Dodge	Iowa	United States	50501
239	McFarland Clinic PC-Jefferson	Jefferson	Iowa	United States	50129
240	McFarland Clinic PC-Marshalltown	Marshalltown	Iowa	United States	50158
241	Mercy Medical Center - North Iowa	Mason City	Iowa	United States	50401
242	Siouxland Regional Cancer Center	Sioux City	Iowa	United States	51101
243	Mercy Medical Center-Sioux City	Sioux City	Iowa	United States	51102
244	Saint Luke's Regional Medical Center	Sioux City	Iowa	United States	51104
245	Abben Cancer Center	Spencer	Iowa	United States	51301
246	MercyOne Waterloo Medical Center	Waterloo	Iowa	United States	50702
247	Mercy Medical Center-West Lakes	West Des Moines	Iowa	United States	50266
248	Cancer Center of Kansas - Chanute	Chanute	Kansas	United States	66720
249	Cancer Center of Kansas - Dodge City	Dodge City	Kansas	United States	67801
250	Cancer Center of Kansas - El Dorado	El Dorado	Kansas	United States	67042
251	Cancer Center of Kansas - Fort Scott	Fort Scott	Kansas	United States	66701
252	Cancer Center of Kansas-Independence	Independence	Kansas	United States	67301
253	Cancer Center of Kansas-Kingman	Kingman	Kansas	United States	67068
254	Lawrence Memorial Hospital	Lawrence	Kansas	United States	66044
255	Kansas Institute of Medicine Cancer and Blood Center	Lenexa	Kansas	United States	66219
256	Minimally Invasive Surgery Hospital	Lenexa	Kansas	United States	66219
257	Cancer Center of Kansas-Liberal	Liberal	Kansas	United States	67905
258	Cancer Center of Kansas - Newton	Newton	Kansas	United States	67114
259	Menorah Medical Center	Overland Park	Kansas	United States	66209
260	Saint Luke's South Hospital	Overland Park	Kansas	United States	66213
261	Cancer Center of Kansas - Parsons	Parsons	Kansas	United States	67357
262	Kansas City NCI Community Oncology Research Program	Prairie Village	Kansas	United States	66208
263	Cancer Center of Kansas - Pratt	Pratt	Kansas	United States	67124
264	Cancer Center of Kansas - Salina	Salina	Kansas	United States	67401
265	Cotton O'Neil Cancer Center / Stormont Vail Health	Topeka	Kansas	United States	66606
266	Cancer Center of Kansas - Wellington	Wellington	Kansas	United States	67152
267	Associates In Womens Health	Wichita	Kansas	United States	67208
268	Cancer Center of Kansas-Wichita Medical Arts Tower	Wichita	Kansas	United States	67208
269	Ascension Via Christi Hospitals Wichita	Wichita	Kansas	United States	67214
270	Cancer Center of Kansas - Wichita	Wichita	Kansas	United States	67214
271	Cancer Center of Kansas - Winfield	Winfield	Kansas	United States	67156
272	Flaget Memorial Hospital	Bardstown	Kentucky	United States	40004
273	Commonwealth Cancer Center-Corbin	Corbin	Kentucky	United States	40701
274	Oncology Hematology Care Inc-Crestview	Crestview Hills	Kentucky	United States	41017
275	Saint Joseph Radiation Oncology Resource Center	Lexington	Kentucky	United States	40504
276	Saint Joseph Hospital East	Lexington	Kentucky	United States	40509
277	Jewish Hospital	Louisville	Kentucky	United States	40202
278	Saints Mary and Elizabeth Hospital	Louisville	Kentucky	United States	40215
279	UofL Health Medical Center Northeast	Louisville	Kentucky	United States	40245
280	Jewish Hospital Medical Center South	Shepherdsville	Kentucky	United States	40165
281	Ochsner Health Center-Summa	Baton Rouge	Louisiana	United States	70809
282	Ochsner Medical Center Kenner	Kenner	Louisiana	United States	70065
283	Ochsner LSU Health Monroe Medical Center	Monroe	Louisiana	United States	71202
284	Ochsner Medical Center Jefferson	New Orleans	Louisiana	United States	70121
285	LSU Health Sciences Center at Shreveport	Shreveport	Louisiana	United States	71103
286	CHRISTUS Highland Medical Center	Shreveport	Louisiana	United States	71105
287	Harold Alfond Center for Cancer Care	Augusta	Maine	United States	04330
288	Eastern Maine Medical Center	Bangor	Maine	United States	04401
289	Lafayette Family Cancer Center-EMMC	Brewer	Maine	United States	04412
290	Penobscot Bay Medical Center	Rockport	Maine	United States	04856
291	University of Maryland/Greenebaum Cancer Center	Baltimore	Maryland	United States	21201
292	Saint Agnes Hospital	Baltimore	Maryland	United States	21229
293	Beverly Hospital	Beverly	Massachusetts	United States	01915
294	Tufts Medical Center	Boston	Massachusetts	United States	02111
295	Eastern Cooperative Oncology Group	Boston	Massachusetts	United States	02215
296	Lahey Hospital and Medical Center	Burlington	Massachusetts	United States	01805
297	Addison Gilbert Hospital	Gloucester	Massachusetts	United States	01930
298	Baystate Medical Center	Springfield	Massachusetts	United States	01199
299	Winchester Hospital	Winchester	Massachusetts	United States	01890
300	UMass Memorial Medical Center - University Campus	Worcester	Massachusetts	United States	01655
301	Bixby Medical Center	Adrian	Michigan	United States	49221
302	Hickman Cancer Center	Adrian	Michigan	United States	49221
303	Michigan Cancer Research Consortium NCORP	Ann Arbor	Michigan	United States	48106
304	Saint Joseph Mercy Hospital	Ann Arbor	Michigan	United States	48106
305	Henry Ford Cancer Institute-Downriver	Brownstown	Michigan	United States	48183
306	Henry Ford Macomb Hospital-Clinton Township	Clinton Township	Michigan	United States	48038
307	Beaumont Hospital - Dearborn	Dearborn	Michigan	United States	48124
308	Henry Ford Medical Center-Fairlane	Dearborn	Michigan	United States	48126
309	Wayne State University/Karmanos Cancer Institute	Detroit	Michigan	United States	48201
310	Henry Ford Hospital	Detroit	Michigan	United States	48202
311	Ascension Saint John Hospital	Detroit	Michigan	United States	48236
312	Green Bay Oncology - Escanaba	Escanaba	Michigan	United States	49829
313	Weisberg Cancer Treatment Center	Farmington Hills	Michigan	United States	48334
314	Beaumont Hospital - Farmington Hills	Farmington Hills	Michigan	United States	48336
315	Genesys Hurley Cancer Institute	Flint	Michigan	United States	48503
316	Hurley Medical Center	Flint	Michigan	United States	48503
317	William Beaumont Hospital-Grosse Pointe	Grosse Pointe	Michigan	United States	48230
318	Green Bay Oncology - Iron Mountain	Iron Mountain	Michigan	United States	49801
319	Allegiance Health	Jackson	Michigan	United States	49201
320	West Michigan Cancer Center	Kalamazoo	Michigan	United States	49007
321	Sparrow Hospital	Lansing	Michigan	United States	48912
322	Trinity Health Saint Mary Mercy Livonia Hospital	Livonia	Michigan	United States	48154
323	Mercy Memorial Hospital	Monroe	Michigan	United States	48162
324	Monroe Cancer Center	Monroe	Michigan	United States	48162
325	Toledo Clinic Cancer Centers-Monroe	Monroe	Michigan	United States	48162
326	Ascension Providence Hospitals - Novi	Novi	Michigan	United States	48374
327	Henry Ford Medical Center-Columbus	Novi	Michigan	United States	48377
328	Saint Joseph Mercy Oakland	Pontiac	Michigan	United States	48341
329	Lake Huron Medical Center	Port Huron	Michigan	United States	48060
330	Michigan Cancer Specialists	Roseville	Michigan	United States	48066
331	Oakland Colon Rectal Associates	Royal Oak	Michigan	United States	48067
332	Cancer Care Associates PC	Royal Oak	Michigan	United States	48073
333	Comprehensive Medical Center PLLC	Royal Oak	Michigan	United States	48073
334	Hematology Oncology Consultants PC	Royal Oak	Michigan	United States	48073
335	Oakland Medical Group	Royal Oak	Michigan	United States	48073
336	William Beaumont Hospital-Royal Oak	Royal Oak	Michigan	United States	48073
337	Ascension Saint Mary's Hospital	Saginaw	Michigan	United States	48601
338	Ascension Providence Hospitals - Southfield	Southfield	Michigan	United States	48075
339	Premier Hematology Oncology Care	Sterling Heights	Michigan	United States	48312
340	Mitchell Folbe MD PC	Sterling Heights	Michigan	United States	48314
341	Michigan Institute of Urology-Town Center	Troy	Michigan	United States	48084
342	Claudia BR Herke MD PC	Troy	Michigan	United States	48085
343	William Beaumont Hospital - Troy	Troy	Michigan	United States	48085
344	Hematology Oncology Consultants PC-Troy	Troy	Michigan	United States	48098
345	Saint John Macomb-Oakland Hospital	Warren	Michigan	United States	48093
346	Henry Ford West Bloomfield Hospital	West Bloomfield	Michigan	United States	48322
347	Sanford Joe Lueken Cancer Center	Bemidji	Minnesota	United States	56601
348	Essentia Health Saint Joseph's Medical Center	Brainerd	Minnesota	United States	56401
349	Fairview Ridges Hospital	Burnsville	Minnesota	United States	55337
350	Mercy Hospital	Coon Rapids	Minnesota	United States	55433
351	Essentia Health Cancer Center	Duluth	Minnesota	United States	55805
352	Essentia Health Saint Mary's Medical Center	Duluth	Minnesota	United States	55805
353	Miller-Dwan Hospital	Duluth	Minnesota	United States	55805
354	Fairview Southdale Hospital	Edina	Minnesota	United States	55435
355	Lake Region Healthcare Corporation-Cancer Care	Fergus Falls	Minnesota	United States	56537
356	Unity Hospital	Fridley	Minnesota	United States	55432
357	Hutchinson Area Health Care	Hutchinson	Minnesota	United States	55350
358	Minnesota Oncology Hematology PA-Maplewood	Maplewood	Minnesota	United States	55109
359	Saint John's Hospital - Healtheast	Maplewood	Minnesota	United States	55109
360	Abbott-Northwestern Hospital	Minneapolis	Minnesota	United States	55407
361	Hennepin County Medical Center	Minneapolis	Minnesota	United States	55415
362	Health Partners Inc	Minneapolis	Minnesota	United States	55454
363	New Ulm Medical Center	New Ulm	Minnesota	United States	56073
364	North Memorial Medical Health Center	Robbinsdale	Minnesota	United States	55422
365	Mayo Clinic in Rochester	Rochester	Minnesota	United States	55905
366	Metro Minnesota Community Oncology Research Consortium	Saint Louis Park	Minnesota	United States	55416
367	Park Nicollet Clinic - Saint Louis Park	Saint Louis Park	Minnesota	United States	55416
368	Regions Hospital	Saint Paul	Minnesota	United States	55101
369	United Hospital	Saint Paul	Minnesota	United States	55102
370	Saint Francis Regional Medical Center	Shakopee	Minnesota	United States	55379
371	Lakeview Hospital	Stillwater	Minnesota	United States	55082
372	Ridgeview Medical Center	Waconia	Minnesota	United States	55387
373	Rice Memorial Hospital	Willmar	Minnesota	United States	56201
374	Minnesota Oncology Hematology PA-Woodbury	Woodbury	Minnesota	United States	55125
375	Central Care Cancer Center - Bolivar	Bolivar	Missouri	United States	65613
376	Parkland Health Center-Bonne Terre	Bonne Terre	Missouri	United States	63628
377	Cox Cancer Center Branson	Branson	Missouri	United States	65616
378	Saint Francis Medical Center	Cape Girardeau	Missouri	United States	63703
379	Southeast Cancer Center	Cape Girardeau	Missouri	United States	63703
380	Siteman Cancer Center at West County Hospital	Creve Coeur	Missouri	United States	63141
381	Centerpoint Medical Center LLC	Independence	Missouri	United States	64057
382	Capital Region Southwest Campus	Jefferson City	Missouri	United States	65109
383	Freeman Health System	Joplin	Missouri	United States	64804
384	Mercy Hospital Joplin	Joplin	Missouri	United States	64804
385	Saint Luke's Hospital of Kansas City	Kansas City	Missouri	United States	64111
386	Heartland Hematology and Oncology Associates Incorporated	Kansas City	Missouri	United States	64118
387	Research Medical Center	Kansas City	Missouri	United States	64132
388	Saint Luke's East - Lee's Summit	Lee's Summit	Missouri	United States	64086
389	Liberty Radiation Oncology Center	Liberty	Missouri	United States	64068
390	Delbert Day Cancer Institute at PCRMC	Rolla	Missouri	United States	65401
391	Mercy Clinic-Rolla-Cancer and Hematology	Rolla	Missouri	United States	65401
392	Heartland Regional Medical Center	Saint Joseph	Missouri	United States	64506
393	Saint Louis Cancer and Breast Institute-South City	Saint Louis	Missouri	United States	63109
394	Washington University School of Medicine	Saint Louis	Missouri	United States	63110
395	Siteman Cancer Center-South County	Saint Louis	Missouri	United States	63129
396	Missouri Baptist Medical Center	Saint Louis	Missouri	United States	63131
397	Mercy Hospital Saint Louis	Saint Louis	Missouri	United States	63141
398	Siteman Cancer Center at Saint Peters Hospital	Saint Peters	Missouri	United States	63376
399	Sainte Genevieve County Memorial Hospital	Sainte Genevieve	Missouri	United States	63670
400	Mercy Hospital Springfield	Springfield	Missouri	United States	65804
401	CoxHealth South Hospital	Springfield	Missouri	United States	65807
402	Missouri Baptist Sullivan Hospital	Sullivan	Missouri	United States	63080
403	Missouri Baptist Outpatient Center-Sunset Hills	Sunset Hills	Missouri	United States	63127
404	Community Hospital of Anaconda	Anaconda	Montana	United States	59711
405	Billings Clinic Cancer Center	Billings	Montana	United States	59101
406	Saint Vincent Healthcare	Billings	Montana	United States	59101
407	Montana Cancer Consortium NCORP	Billings	Montana	United States	59102
408	Bozeman Deaconess Hospital	Bozeman	Montana	United States	59715
409	Saint James Community Hospital and Cancer Treatment Center	Butte	Montana	United States	59701
410	Benefis Healthcare- Sletten Cancer Institute	Great Falls	Montana	United States	59405
411	Great Falls Clinic	Great Falls	Montana	United States	59405
412	Saint Peter's Community Hospital	Helena	Montana	United States	59601
413	Kalispell Regional Medical Center	Kalispell	Montana	United States	59901
414	Saint Patrick Hospital - Community Hospital	Missoula	Montana	United States	59802
415	Community Medical Hospital	Missoula	Montana	United States	59804
416	CHI Health Saint Francis	Grand Island	Nebraska	United States	68803
417	Heartland Hematology and Oncology	Kearney	Nebraska	United States	68845
418	CHI Health Good Samaritan	Kearney	Nebraska	United States	68847
419	Nebraska Hematology and Oncology	Lincoln	Nebraska	United States	68506
420	Nebraska Cancer Research Center	Lincoln	Nebraska	United States	68510
421	Saint Elizabeth Regional Medical Center	Lincoln	Nebraska	United States	68510
422	Southeast Nebraska Cancer Center - 68th Street Place	Lincoln	Nebraska	United States	68516
423	Faith Regional Health Services Carson Cancer Center	Norfolk	Nebraska	United States	68701
424	Great Plains Health Callahan Cancer Center	North Platte	Nebraska	United States	69101
425	Missouri Valley Cancer Consortium	Omaha	Nebraska	United States	68106
426	Alegent Health Immanuel Medical Center	Omaha	Nebraska	United States	68122
427	Hematology and Oncology Consultants PC	Omaha	Nebraska	United States	68122
428	Alegent Health Bergan Mercy Medical Center	Omaha	Nebraska	United States	68124
429	Nebraska Cancer Specialists - Omaha	Omaha	Nebraska	United States	68124
430	Alegent Health Lakeside Hospital	Omaha	Nebraska	United States	68130
431	Oncology Hematology West PC	Omaha	Nebraska	United States	68130
432	Creighton University Medical Center	Omaha	Nebraska	United States	68131
433	University of Nebraska Medical Center	Omaha	Nebraska	United States	68198
434	Midlands Community Hospital	Papillion	Nebraska	United States	68046
435	Regional West Medical Center Cancer Center	Scottsbluff	Nebraska	United States	69361
436	Cancer and Blood Specialists-Henderson	Henderson	Nevada	United States	89052
437	Comprehensive Cancer Centers of Nevada - Henderson	Henderson	Nevada	United States	89052
438	Las Vegas Cancer Center-Henderson	Henderson	Nevada	United States	89052
439	Comprehensive Cancer Centers of Nevada-Southeast Henderson	Henderson	Nevada	United States	89074
440	GenesisCare USA - Henderson	Henderson	Nevada	United States	89074
441	Cancer and Blood Specialists-Shadow	Las Vegas	Nevada	United States	89106
442	Radiation Oncology Centers of Nevada Central	Las Vegas	Nevada	United States	89106
443	GenesisCare USA - Las Vegas	Las Vegas	Nevada	United States	89109
444	HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway	Las Vegas	Nevada	United States	89109
445	HealthCare Partners Medical Group Oncology/Hematology-San Martin	Las Vegas	Nevada	United States	89113
446	Radiation Oncology Centers of Nevada Southeast	Las Vegas	Nevada	United States	89119
447	Cancer Therapy and Integrative Medicine	Las Vegas	Nevada	United States	89121
448	Cancer and Blood Specialists-Tenaya	Las Vegas	Nevada	United States	89128
449	Comprehensive Cancer Centers of Nevada - Northwest	Las Vegas	Nevada	United States	89128
450	GenesisCare USA - Vegas Tenaya	Las Vegas	Nevada	United States	89128
451	HealthCare Partners Medical Group Oncology/Hematology-Tenaya	Las Vegas	Nevada	United States	89128
452	Comprehensive Cancer Centers of Nevada-Summerlin	Las Vegas	Nevada	United States	89144
453	Summerlin Hospital Medical Center	Las Vegas	Nevada	United States	89144
454	Las Vegas Cancer Center-Medical Center	Las Vegas	Nevada	United States	89148-2405
455	Comprehensive Cancer Centers of Nevada	Las Vegas	Nevada	United States	89148
456	GenesisCare USA - Fort Apache	Las Vegas	Nevada	United States	89148
457	OptumCare Cancer Care at Fort Apache	Las Vegas	Nevada	United States	89148
458	HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills	Las Vegas	Nevada	United States	89149
459	Comprehensive Cancer Centers of Nevada - Central Valley	Las Vegas	Nevada	United States	89169
460	Nevada Cancer Research Foundation NCORP	Las Vegas	Nevada	United States	89169
461	Saint Mary's Regional Medical Center	Reno	Nevada	United States	89503
462	Wentworth-Douglass Hospital	Dover	New Hampshire	United States	03820
463	Veterans Adminstration New Jersey Health Care System	East Orange	New Jersey	United States	07018-1095
464	Newark Beth Israel Medical Center	Newark	New Jersey	United States	07112
465	University of New Mexico Cancer Center	Albuquerque	New Mexico	United States	87102
466	New York Oncology Hematology PC - Albany Medical Center	Albany	New York	United States	12208
467	Hematology Oncology Associates of Central New York-Auburn	Auburn	New York	United States	13021
468	Roswell Park Cancer Institute	Buffalo	New York	United States	14263
469	Glens Falls Hospital	Glens Falls	New York	United States	12801
470	Northwell Health/Center for Advanced Medicine	Lake Success	New York	United States	11042
471	Hematology Oncology Associates of Central New York-Liverpool	Liverpool	New York	United States	13088
472	North Shore University Hospital	Manhasset	New York	United States	11030
473	Garnet Health Medical Center	Middletown	New York	United States	10940
474	Long Island Jewish Medical Center	New Hyde Park	New York	United States	11040
475	University of Rochester	Rochester	New York	United States	14642
476	Hematology Oncology Associates of Central New York-Rome	Rome	New York	United States	13440
477	State University of New York Upstate Medical University	Syracuse	New York	United States	13210
478	Hematology Oncology Associates of Central New York-Onondaga Hill	Syracuse	New York	United States	13215
479	Mission Hospital	Asheville	North Carolina	United States	28801
480	AdventHealth Infusion Center Asheville	Asheville	North Carolina	United States	28803
481	Messino Cancer Centers	Asheville	North Carolina	United States	28806
482	Sampson Radiation Oncology	Clinton	North Carolina	United States	28328
483	Southeastern Medical Oncology Center-Clinton	Clinton	North Carolina	United States	28328
484	Southeastern Medical Oncology Center-Goldsboro	Goldsboro	North Carolina	United States	27534
485	Wayne Memorial Hospital	Goldsboro	North Carolina	United States	27534
486	Wayne Radiation Oncology	Goldsboro	North Carolina	United States	27534
487	Hendersonville Hematology and Oncology at Pardee	Hendersonville	North Carolina	United States	28791
488	Margaret R Pardee Memorial Hospital	Hendersonville	North Carolina	United States	28791
489	AdventHealth Hendersonville	Hendersonville	North Carolina	United States	28792
490	Onslow Memorial Hospital	Jacksonville	North Carolina	United States	28546
491	Southeastern Medical Oncology Center-Jacksonville	Jacksonville	North Carolina	United States	28546
492	Vidant Oncology-Kinston	Kinston	North Carolina	United States	28501
493	Wake Forest University Health Sciences	Winston-Salem	North Carolina	United States	27157
494	Sanford Bismarck Medical Center	Bismarck	North Dakota	United States	58501
495	Essentia Health Cancer Center-South University Clinic	Fargo	North Dakota	United States	58103
496	Sanford Broadway Medical Center	Fargo	North Dakota	United States	58122
497	Sanford Clinic North-Fargo	Fargo	North Dakota	United States	58122
498	Sanford Roger Maris Cancer Center	Fargo	North Dakota	United States	58122
499	Cleveland Clinic Akron General	Akron	Ohio	United States	44307
500	UHHS-Chagrin Highlands Medical Center	Beachwood	Ohio	United States	44122
501	Strecker Cancer Center-Belpre	Belpre	Ohio	United States	45714
502	Toledo Clinic Cancer Centers-Bowling Green	Bowling Green	Ohio	United States	43402
503	Dayton Physicians LLC-Miami Valley South	Centerville	Ohio	United States	45459
504	Miami Valley Hospital South	Centerville	Ohio	United States	45459
505	Geauga Hospital	Chardon	Ohio	United States	44024
506	Adena Regional Medical Center	Chillicothe	Ohio	United States	45601
507	Oncology Hematology Care Inc-Eden Park	Cincinnati	Ohio	United States	45202
508	Oncology Hematology Care Inc-Mercy West	Cincinnati	Ohio	United States	45211
509	University of Cincinnati Cancer Center-UC Medical Center	Cincinnati	Ohio	United States	45219
510	Good Samaritan Hospital - Cincinnati	Cincinnati	Ohio	United States	45220
511	Oncology Hematology Care Inc-Anderson	Cincinnati	Ohio	United States	45230
512	Oncology Hematology Care Inc-Kenwood	Cincinnati	Ohio	United States	45236
513	Bethesda North Hospital	Cincinnati	Ohio	United States	45242
514	Oncology Hematology Care Inc-Blue Ash	Cincinnati	Ohio	United States	45242
515	TriHealth Cancer Institute-Westside	Cincinnati	Ohio	United States	45247
516	TriHealth Cancer Institute-Anderson	Cincinnati	Ohio	United States	45255
517	Case Western Reserve University	Cleveland	Ohio	United States	44106
518	MetroHealth Medical Center	Cleveland	Ohio	United States	44109
519	Mount Carmel East Hospital	Columbus	Ohio	United States	43213
520	Columbus Oncology and Hematology Associates Inc	Columbus	Ohio	United States	43214
521	Riverside Methodist Hospital	Columbus	Ohio	United States	43214
522	Columbus NCI Community Oncology Research Program	Columbus	Ohio	United States	43215
523	Grant Medical Center	Columbus	Ohio	United States	43215
524	The Mark H Zangmeister Center	Columbus	Ohio	United States	43219
525	Mount Carmel Health Center West	Columbus	Ohio	United States	43222
526	Doctors Hospital	Columbus	Ohio	United States	43228
527	Good Samaritan Hospital - Dayton	Dayton	Ohio	United States	45406
528	Miami Valley Hospital	Dayton	Ohio	United States	45409
529	Dayton Physician LLC-Miami Valley Hospital North	Dayton	Ohio	United States	45415
530	Miami Valley Hospital North	Dayton	Ohio	United States	45415
531	Dayton Veterans Affairs Medical Center	Dayton	Ohio	United States	45428
532	Dayton NCI Community Oncology Research Program	Dayton	Ohio	United States	45459
533	Delaware Health Center-Grady Cancer Center	Delaware	Ohio	United States	43015
534	Delaware Radiation Oncology	Delaware	Ohio	United States	43015
535	Grady Memorial Hospital	Delaware	Ohio	United States	43015
536	Mercy Cancer Center-Elyria	Elyria	Ohio	United States	44035
537	Oncology Hematology Care Inc-Healthplex	Fairfield	Ohio	United States	45014
538	Armes Family Cancer Center	Findlay	Ohio	United States	45840
539	Blanchard Valley Hospital	Findlay	Ohio	United States	45840
540	Orion Cancer Care	Findlay	Ohio	United States	45840
541	Atrium Medical Center-Middletown Regional Hospital	Franklin	Ohio	United States	45005-1066
542	Dayton Physicians LLC-Atrium	Franklin	Ohio	United States	45005
543	Dayton Physicians LLC-Wayne	Greenville	Ohio	United States	45331
544	Wayne Hospital	Greenville	Ohio	United States	45331
545	Greater Dayton Cancer Center	Kettering	Ohio	United States	45409
546	Kettering Medical Center	Kettering	Ohio	United States	45429
547	Fairfield Medical Center	Lancaster	Ohio	United States	43130
548	Lancaster Radiation Oncology	Lancaster	Ohio	United States	43130
549	Lima Memorial Hospital	Lima	Ohio	United States	45804
550	OhioHealth Mansfield Hospital	Mansfield	Ohio	United States	44903
551	Marietta Memorial Hospital	Marietta	Ohio	United States	45750
552	OhioHealth Marion General Hospital	Marion	Ohio	United States	43302
553	Toledo Clinic Cancer Centers-Maumee	Maumee	Ohio	United States	43537
554	Toledo Radiation Oncology at Northwest Ohio Onocolgy Center	Maumee	Ohio	United States	43537
555	UH Seidman Cancer Center at Landerbrook Health Center	Mayfield Heights	Ohio	United States	44124
556	UH Seidman Cancer Center at Lake Health Mentor Campus	Mentor	Ohio	United States	44060
557	UH Seidman Cancer Center at Southwest General Hospital	Middleburg Heights	Ohio	United States	44130
558	Dayton Physicians LLC-Signal Point	Middletown	Ohio	United States	45042
559	Knox Community Hospital	Mount Vernon	Ohio	United States	43050
560	Licking Memorial Hospital	Newark	Ohio	United States	43055
561	Newark Radiation Oncology	Newark	Ohio	United States	43055
562	Saint Charles Hospital	Oregon	Ohio	United States	43616
563	Toledo Clinic Cancer Centers-Oregon	Oregon	Ohio	United States	43616
564	University Hospitals Parma Medical Center	Parma	Ohio	United States	44129
565	Southern Ohio Medical Center	Portsmouth	Ohio	United States	45662
566	Dayton Physicians LLC-Wilson	Sidney	Ohio	United States	45365
567	Springfield Regional Cancer Center	Springfield	Ohio	United States	45504
568	Springfield Regional Medical Center	Springfield	Ohio	United States	45505
569	ProMedica Flower Hospital	Sylvania	Ohio	United States	43560
570	Mercy Hospital of Tiffin	Tiffin	Ohio	United States	44883
571	Saint Vincent Mercy Medical Center	Toledo	Ohio	United States	43608
572	University of Toledo	Toledo	Ohio	United States	43614
573	Toledo Community Hospital Oncology Program CCOP	Toledo	Ohio	United States	43617
574	Mercy Health - Saint Anne Hospital	Toledo	Ohio	United States	43623
575	Toledo Clinic Cancer Centers-Toledo	Toledo	Ohio	United States	43623
576	Dayton Physicians LLC-Upper Valley	Troy	Ohio	United States	45373
577	Upper Valley Medical Center	Troy	Ohio	United States	45373
578	University Hospitals Sharon Health Center	Wadsworth	Ohio	United States	44281
579	Fulton County Health Center	Wauseon	Ohio	United States	43567
580	University of Cincinnati Cancer Center-West Chester	West Chester	Ohio	United States	45069
581	Saint Ann's Hospital	Westerville	Ohio	United States	43081
582	UH Seidman Cancer Center at Saint John Medical Center	Westlake	Ohio	United States	44145
583	Wright-Patterson Medical Center	Wright-Patterson Air Force Base	Ohio	United States	45433
584	Genesis Healthcare System Cancer Care Center	Zanesville	Ohio	United States	43701
585	Cancer Centers of Southwest Oklahoma Research	Lawton	Oklahoma	United States	73505
586	University of Oklahoma Health Sciences Center	Oklahoma City	Oklahoma	United States	73104
587	Saint Charles Health System	Bend	Oregon	United States	97701
588	Clackamas Radiation Oncology Center	Clackamas	Oregon	United States	97015
589	Providence Cancer Institute Clackamas Clinic	Clackamas	Oregon	United States	97015
590	Bay Area Hospital	Coos Bay	Oregon	United States	97420
591	Providence Milwaukie Hospital	Milwaukie	Oregon	United States	97222
592	Providence Newberg Medical Center	Newberg	Oregon	United States	97132
593	Providence Willamette Falls Medical Center	Oregon City	Oregon	United States	97045
594	Providence Portland Medical Center	Portland	Oregon	United States	97213
595	Providence Saint Vincent Medical Center	Portland	Oregon	United States	97225
596	Kaiser Permanente Northwest	Portland	Oregon	United States	97227
597	Lehigh Valley Hospital-Cedar Crest	Allentown	Pennsylvania	United States	18103
598	UPMC-Heritage Valley Health System Beaver	Beaver	Pennsylvania	United States	15009
599	Lehigh Valley Hospital - Muhlenberg	Bethlehem	Pennsylvania	United States	18017
600	Bryn Mawr Hospital	Bryn Mawr	Pennsylvania	United States	19010
601	Christiana Care Health System-Concord Health Center	Chadds Ford	Pennsylvania	United States	19317
602	Geisinger Medical Center	Danville	Pennsylvania	United States	17822
603	UPMC Hillman Cancer Center Erie	Erie	Pennsylvania	United States	16505
604	UPMC Cancer Centers - Arnold Palmer Pavilion	Greensburg	Pennsylvania	United States	15601
605	Geisinger Medical Center-Cancer Center Hazleton	Hazleton	Pennsylvania	United States	18201
606	Penn State Milton S Hershey Medical Center	Hershey	Pennsylvania	United States	17033-0850
607	UPMC-Johnstown/John P. Murtha Regional Cancer Center	Johnstown	Pennsylvania	United States	15901
608	Lancaster General Hospital	Lancaster	Pennsylvania	United States	17602
609	Geisinger Medical Oncology-Lewisburg	Lewisburg	Pennsylvania	United States	17837
610	Lewistown Hospital	Lewistown	Pennsylvania	United States	17044
611	UPMC Cancer Center at UPMC McKeesport	McKeesport	Pennsylvania	United States	15132
612	Riddle Memorial Hospital	Media	Pennsylvania	United States	19063
613	UPMC-Coraopolis/Heritage Valley Radiation Oncology	Moon	Pennsylvania	United States	15108
614	Paoli Memorial Hospital	Paoli	Pennsylvania	United States	19301
615	Drexel University School of Medicine	Philadelphia	Pennsylvania	United States	19102
616	University of Pennsylvania/Abramson Cancer Center	Philadelphia	Pennsylvania	United States	19104
617	Thomas Jefferson University Hospital	Philadelphia	Pennsylvania	United States	19107
618	UPMC-Magee Womens Hospital	Pittsburgh	Pennsylvania	United States	15213
619	UPMC-Presbyterian Hospital	Pittsburgh	Pennsylvania	United States	15213
620	UPMC-Saint Margaret	Pittsburgh	Pennsylvania	United States	15215
621	University of Pittsburgh Cancer Institute (UPCI)	Pittsburgh	Pennsylvania	United States	15232
622	UPMC-Shadyside Hospital	Pittsburgh	Pennsylvania	United States	15232
623	UPMC Jefferson Regional Radiation Oncology	Pittsburgh	Pennsylvania	United States	15236
624	UPMC-Passavant Hospital	Pittsburgh	Pennsylvania	United States	15237
625	UPMC-Saint Clair Hospital Cancer Center	Pittsburgh	Pennsylvania	United States	15243
626	Pottstown Hospital	Pottstown	Pennsylvania	United States	19464
627	Geisinger Cancer Services-Pottsville	Pottsville	Pennsylvania	United States	17901
628	Hematology and Oncology Associates of North East Pennsylvania	Scranton	Pennsylvania	United States	18508
629	UPMC Cancer Center at UPMC Northwest	Seneca	Pennsylvania	United States	16346
630	Geisinger Medical Group	State College	Pennsylvania	United States	16801
631	UPMC Uniontown Hospital Radiation Oncology	Uniontown	Pennsylvania	United States	15401
632	UPMC Washington Hospital Radiation Oncology	Washington	Pennsylvania	United States	15301
633	Reading Hospital	West Reading	Pennsylvania	United States	19611
634	Geisinger Wyoming Valley/Henry Cancer Center	Wilkes-Barre	Pennsylvania	United States	18711
635	UPMC Susquehanna	Williamsport	Pennsylvania	United States	17701
636	Lankenau Medical Center	Wynnewood	Pennsylvania	United States	19096
637	Prisma Health Cancer Institute - Spartanburg	Boiling Springs	South Carolina	United States	29316
638	Prisma Health Cancer Institute - Easley	Easley	South Carolina	United States	29640
639	Gibbs Cancer Center-Gaffney	Gaffney	South Carolina	United States	29341
640	Greenville Health System Cancer Institute-Andrews	Greenville	South Carolina	United States	29601
641	Saint Francis Hospital	Greenville	South Carolina	United States	29601
642	Prisma Health Cancer Institute - Butternut	Greenville	South Carolina	United States	29605
643	Prisma Health Cancer Institute - Faris	Greenville	South Carolina	United States	29605
644	Prisma Health Greenville Memorial Hospital	Greenville	South Carolina	United States	29605
645	Saint Francis Cancer Center	Greenville	South Carolina	United States	29607
646	Prisma Health Cancer Institute - Eastside	Greenville	South Carolina	United States	29615
647	Prisma Health Cancer Institute - Greer	Greer	South Carolina	United States	29650
648	Gibbs Cancer Center-Pelham	Greer	South Carolina	United States	29651
649	Prisma Health Cancer Institute - Seneca	Seneca	South Carolina	United States	29672
650	Spartanburg Medical Center	Spartanburg	South Carolina	United States	29303
651	MGC Hematology Oncology-Union	Union	South Carolina	United States	29379
652	Rapid City Regional Hospital	Rapid City	South Dakota	United States	57701
653	Sanford Cancer Center Oncology Clinic	Sioux Falls	South Dakota	United States	57104
654	Avera Cancer Institute	Sioux Falls	South Dakota	United States	57105
655	Sanford USD Medical Center - Sioux Falls	Sioux Falls	South Dakota	United States	57117-5134
656	Bristol Regional Medical Center	Bristol	Tennessee	United States	37620
657	Memorial Hospital	Chattanooga	Tennessee	United States	37404
658	Pulmonary Medicine Center of Chattanooga-Hixson	Hixson	Tennessee	United States	37343
659	Wellmont Medical Associates Oncology and Hematology-Johnson City	Johnson City	Tennessee	United States	37604
660	Ballad Health Cancer Care - Kingsport	Kingsport	Tennessee	United States	37660
661	Wellmont Holston Valley Hospital and Medical Center	Kingsport	Tennessee	United States	37660
662	Meharry Medical College	Nashville	Tennessee	United States	37208
663	Memorial GYN Plus	Ooltewah	Tennessee	United States	37363
664	The Don and Sybil Harrington Cancer Center	Amarillo	Texas	United States	79106
665	Parkland Memorial Hospital	Dallas	Texas	United States	75235
666	UT Southwestern/Simmons Cancer Center-Dallas	Dallas	Texas	United States	75390
667	Covenant Medical Center-Lakeside	Lubbock	Texas	United States	79410
668	University Hospital	San Antonio	Texas	United States	78229
669	University of Texas Health Science Center at San Antonio	San Antonio	Texas	United States	78229
670	Central Vermont Medical Center/National Life Cancer Treatment	Berlin	Vermont	United States	05602
671	University of Vermont Medical Center	Burlington	Vermont	United States	05401
672	University of Vermont and State Agricultural College	Burlington	Vermont	United States	05405
673	Danville Regional Medical Center	Danville	Virginia	United States	24541
674	Fredericksburg Oncology Inc	Fredericksburg	Virginia	United States	22401
675	Hematology Oncology Associates of Fredericksburg Inc	Fredericksburg	Virginia	United States	22408
676	Centra Lynchburg Hematology-Oncology Clinic Inc	Lynchburg	Virginia	United States	24501
677	Sovah Health Martinsville	Martinsville	Virginia	United States	24115
678	Southwest VA Regional Cancer Center	Norton	Virginia	United States	24273
679	Virginia Cancer Institute	Richmond	Virginia	United States	23229
680	Virginia Commonwealth University/Massey Cancer Center	Richmond	Virginia	United States	23298
681	VCU Community Memorial Health Center	South Hill	Virginia	United States	23970
682	Providence Regional Cancer System-Aberdeen	Aberdeen	Washington	United States	98520
683	Cancer Care Center at Island Hospital	Anacortes	Washington	United States	98221
684	MultiCare Auburn Medical Center	Auburn	Washington	United States	98001
685	Virginia Mason Bainbridge Island Medical Center	Bainbridge Island	Washington	United States	98110
686	Overlake Medical Center	Bellevue	Washington	United States	98004
687	Swedish Cancer Institute-Eastside Oncology Hematology	Bellevue	Washington	United States	98005
688	PeaceHealth Saint Joseph Medical Center	Bellingham	Washington	United States	98225
689	Harrison HealthPartners Hematology and Oncology-Bremerton	Bremerton	Washington	United States	98310
690	Harrison Medical Center	Bremerton	Washington	United States	98310
691	Highline Medical Center-Main Campus	Burien	Washington	United States	98166
692	Providence Regional Cancer System-Centralia	Centralia	Washington	United States	98531
693	Swedish Cancer Institute-Edmonds	Edmonds	Washington	United States	98026
694	Saint Elizabeth Hospital	Enumclaw	Washington	United States	98022
695	Providence Regional Cancer Partnership	Everett	Washington	United States	98201
696	Virginia Mason Federal Way Medical Center	Federal Way	Washington	United States	98002
697	Saint Francis Hospital	Federal Way	Washington	United States	98003
698	Tacoma/Valley Radiation Oncology Centers-Gig Harbor	Gig Harbor	Washington	United States	98332
699	MultiCare Gig Harbor Medical Park	Gig Harbor	Washington	United States	98335
700	Swedish Cancer Institute-Issaquah	Issaquah	Washington	United States	98029
701	Northwest Cancer Clinic	Kennewick	Washington	United States	99336
702	Providence Regional Cancer System-Lacey	Lacey	Washington	United States	98503
703	Saint Clare Hospital	Lakewood	Washington	United States	98499
704	PeaceHealth Saint John Medical Center	Longview	Washington	United States	98632
705	Virginia Mason Lynnwood Medical Center	Lynnwood	Washington	United States	98036
706	Jefferson Healthcare	Port Townsend	Washington	United States	98368
707	Harrison HealthPartners Hematology and Oncology-Poulsbo	Poulsbo	Washington	United States	98370
708	Peninsula Cancer Center	Poulsbo	Washington	United States	98370
709	MultiCare Good Samaritan Hospital	Puyallup	Washington	United States	98372
710	Tacoma/Valley Radiation Oncology Centers-Puyallup	Puyallup	Washington	United States	98372
711	Virginia Mason Medical Center	Seattle	Washington	United States	98101
712	Minor and James Medical PLLC	Seattle	Washington	United States	98104
713	Pacific Gynecology Specialists	Seattle	Washington	United States	98104
714	Swedish Medical Center-Ballard Campus	Seattle	Washington	United States	98107
715	Fred Hutchinson Cancer Research Center	Seattle	Washington	United States	98109
716	Seattle Cancer Care Alliance	Seattle	Washington	United States	98109
717	Kaiser Permanente Washington	Seattle	Washington	United States	98112
718	Swedish Medical Center-First Hill	Seattle	Washington	United States	98122-4307
719	University of Washington Medical Center - Montlake	Seattle	Washington	United States	98195
720	Providence Regional Cancer System-Shelton	Shelton	Washington	United States	98584
721	MultiCare Deaconess Cancer and Blood Specialty Center - Valley	Spokane Valley	Washington	United States	99216
722	MultiCare Deaconess Cancer and Blood Specialty Center - Downtown	Spokane	Washington	United States	99204
723	Evergreen Hematology and Oncology PS	Spokane	Washington	United States	99218
724	Tacoma/Valley Radiation Oncology Centers-Jackson Hall	Tacoma	Washington	United States	97405
725	Franciscan Research Center-Northwest Medical Plaza	Tacoma	Washington	United States	98405
726	MultiCare Tacoma General Hospital	Tacoma	Washington	United States	98405
727	Northwest Medical Specialties PLLC	Tacoma	Washington	United States	98405
728	Northwest NCI Community Oncology Research Program	Tacoma	Washington	United States	98405
729	Tacoma/Valley Radiation Oncology Centers-Saint Joe's	Tacoma	Washington	United States	98405
730	PeaceHealth Southwest Medical Center	Vancouver	Washington	United States	98664
731	Providence Saint Mary Regional Cancer Center	Walla Walla	Washington	United States	99362
732	North Star Lodge Cancer Center at Yakima Valley Memorial Hospital	Yakima	Washington	United States	98902
733	Providence Regional Cancer System-Yelm	Yelm	Washington	United States	98597
734	United Hospital Center	Bridgeport	West Virginia	United States	26330
735	WVUH-Berkely Medical Center	Martinsburg	West Virginia	United States	25401
736	West Virginia University Healthcare	Morgantown	West Virginia	United States	26506
737	Camden Clark Medical Center	Parkersburg	West Virginia	United States	26101
738	Langlade Hospital and Cancer Center	Antigo	Wisconsin	United States	54409
739	Aurora Cancer Care-Southern Lakes VLCC	Burlington	Wisconsin	United States	53105
740	Marshfield Clinic-Chippewa Center	Chippewa Falls	Wisconsin	United States	54729
741	HSHS Sacred Heart Hospital	Eau Claire	Wisconsin	United States	54701
742	Marshfield Clinic Cancer Center at Sacred Heart	Eau Claire	Wisconsin	United States	54701
743	Aurora Health Center-Fond du Lac	Fond Du Lac	Wisconsin	United States	54937
744	Aurora Health Care Germantown Health Center	Germantown	Wisconsin	United States	53022
745	Aurora Cancer Care-Grafton	Grafton	Wisconsin	United States	53024
746	Green Bay Oncology at Saint Vincent Hospital	Green Bay	Wisconsin	United States	54301-3526
747	Bellin Memorial Hospital	Green Bay	Wisconsin	United States	54301
748	Saint Vincent Hospital Cancer Center Green Bay	Green Bay	Wisconsin	United States	54301
749	Green Bay Oncology Limited at Saint Mary's Hospital	Green Bay	Wisconsin	United States	54303
750	Saint Vincent Hospital Cancer Center at Saint Mary's	Green Bay	Wisconsin	United States	54303
751	Aurora BayCare Medical Center	Green Bay	Wisconsin	United States	54311
752	Mercyhealth Hospital and Cancer Center - Janesville	Janesville	Wisconsin	United States	53548
753	Aurora Cancer Care-Kenosha South	Kenosha	Wisconsin	United States	53142
754	Gundersen Lutheran Medical Center	La Crosse	Wisconsin	United States	54601
755	Marshfield Clinic - Ladysmith Center	Ladysmith	Wisconsin	United States	54848
756	Holy Family Memorial Hospital	Manitowoc	Wisconsin	United States	54221
757	Aurora Bay Area Medical Group-Marinette	Marinette	Wisconsin	United States	54143
758	Marshfield Medical Center-Marshfield	Marshfield	Wisconsin	United States	54449
759	Marshfield Medical Center	Marshfield	Wisconsin	United States	54449
760	Aurora Cancer Care-Milwaukee	Milwaukee	Wisconsin	United States	53209
761	Aurora Saint Luke's Medical Center	Milwaukee	Wisconsin	United States	53215
762	Medical College of Wisconsin	Milwaukee	Wisconsin	United States	53226
763	Aurora Sinai Medical Center	Milwaukee	Wisconsin	United States	53233
764	Marshfield Clinic-Minocqua Center	Minocqua	Wisconsin	United States	54548
765	ProHealth D N Greenwald Center	Mukwonago	Wisconsin	United States	53149
766	Cancer Center of Western Wisconsin	New Richmond	Wisconsin	United States	54017
767	ProHealth Oconomowoc Memorial Hospital	Oconomowoc	Wisconsin	United States	53066
768	Saint Vincent Hospital Cancer Center at Oconto Falls	Oconto Falls	Wisconsin	United States	54154
769	Vince Lombardi Cancer Clinic - Oshkosh	Oshkosh	Wisconsin	United States	54904
770	Aurora Cancer Care-Racine	Racine	Wisconsin	United States	53406
771	Ascension Saint Mary's Hospital	Rhinelander	Wisconsin	United States	54501
772	Saint Mary's Hospital	Rhinelander	Wisconsin	United States	54501
773	Marshfield Medical Center-Rice Lake	Rice Lake	Wisconsin	United States	54868
774	HSHS Saint Nicholas Hospital	Sheboygan	Wisconsin	United States	53081
775	Vince Lombardi Cancer Clinic-Sheboygan	Sheboygan	Wisconsin	United States	53081
776	Ascension Saint Michael's Hospital	Stevens Point	Wisconsin	United States	54481
777	Green Bay Oncology - Sturgeon Bay	Sturgeon Bay	Wisconsin	United States	54235
778	Aurora Medical Center in Summit	Summit	Wisconsin	United States	53066
779	Vince Lombardi Cancer Clinic-Two Rivers	Two Rivers	Wisconsin	United States	54241
780	Aurora Cancer Care-Waukesha	Waukesha	Wisconsin	United States	53188
781	ProHealth Waukesha Memorial Hospital	Waukesha	Wisconsin	United States	53188
782	UW Cancer Center at ProHealth Care	Waukesha	Wisconsin	United States	53188
783	Aspirus Regional Cancer Center	Wausau	Wisconsin	United States	54401
784	Marshfield Clinic-Wausau Center	Wausau	Wisconsin	United States	54401
785	Aurora Cancer Care-Milwaukee West	Wauwatosa	Wisconsin	United States	53226
786	Aurora West Allis Medical Center	West Allis	Wisconsin	United States	53227
787	Ascension Saint Clare's Hospital	Weston	Wisconsin	United States	54476
788	Diagnostic and Treatment Center	Weston	Wisconsin	United States	54476
789	Marshfield Medical Center - Weston	Weston	Wisconsin	United States	54476
790	Aspirus Cancer Care - Wisconsin Rapids	Wisconsin Rapids	Wisconsin	United States	54494
791	Marshfield Clinic - Wisconsin Rapids Center	Wisconsin Rapids	Wisconsin	United States	54494
792	Rocky Mountain Oncology	Casper	Wyoming	United States	82609
793	Cheyenne Regional Medical Center-West	Cheyenne	Wyoming	United States	82001
794	Big Horn Basin Cancer Center	Cody	Wyoming	United States	82414
795	Billings Clinic-Cody	Cody	Wyoming	United States	82414
796	Welch Cancer Center	Sheridan	Wyoming	United States	82801

Sponsors and Collaborators

• National Cancer Institute (NCI)

Investigators

• Principal Investigator: Tait D Shanafelt, ECOG-ACRIN Cancer Research Group

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: National Cancer Institute (NCI)
• ClinicalTrials.gov Identifier: NCT02048813
• Other Study ID Numbers: NCI-2014-00118; NCI-2014-00118; E1912; ECOG-E1912; E1912; E1912; R01CA193541; U10CA180820; U10CA021115; U24CA196172
• First Posted: Jan 29, 2014
• Last Update Posted: Aug 12, 2022
• Last Verified: Aug 1, 2022

• Additional relevant MeSH terms: Lymphoma; Leukemia; Leukemia, Lymphoid; Leukemia, Lymphocytic, Chronic, B-Cell; Cyclophosphamide; Rituximab; Fludarabine; Fludarabine phosphate; Antineoplastic Agents, Immunological; Antibodies; Immunoglobulins; Antibodies, Monoclonal

Study Results

No Results Posted as of Aug 12, 2022