Effects of Different Types of Anaesthesia on Intraocular Pressure During Lumbar Disc Herniation Surgery

Sponsor

Giresun University (Other)

Overall Status

Completed

CT.gov ID

NCT06070480

Collaborator

(none)

Enrollment

Location

Arms

16.3

Actual Duration (Months)

4.6

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The aim of this study was to investigate the effects of anaesthesia methods on intraocular pressure during lumbar disc surgery performed in the prone position.

Condition or Disease	Intervention/Treatment	Phase
Anesthesia Disk Herniated Lumbar Intraocular Pressure	Other: Spinal Anesthesia Group Other: Desflurane Group Other: Propofol Group	N/A

Detailed Description

Study Design

Study Type:

Interventional

Actual Enrollment :

75 participants

Allocation:

Randomized

Intervention Model:

Parallel Assignment

Intervention Model Description:

The study included 75 patients with lumbar disc herniation between the ages of 18-75, with the American Society of Anesthesiologists (ASA) 1-2. The patients were randomly divided into 3 groups: propofol, desflurane, spinal. Intraocular pressure was measured at 5 time points throughout surgery, including baseline (T1), 10 minutes after anesthesia (T2), 10 minutes after prone positioning (T3: early prone), 30 minutes after prone positioning (T4: late prone), and 10 minutes after returning to the supine position (T5). Hemodynamic parameters were measured at these time points. Hemoglobin and hematocrit values were measured preoperatively and on the first postoperative day.The study included 75 patients with lumbar disc herniation between the ages of 18-75, with the American Society of Anesthesiologists (ASA) 1-2. The patients were randomly divided into 3 groups: propofol, desflurane, spinal. Intraocular pressure was measured at 5 time points throughout surgery, including baseline (T1), 10 minutes after anesthesia (T2), 10 minutes after prone positioning (T3: early prone), 30 minutes after prone positioning (T4: late prone), and 10 minutes after returning to the supine position (T5). Hemodynamic parameters were measured at these time points. Hemoglobin and hematocrit values were measured preoperatively and on the first postoperative day.

Masking:

None (Open Label)

Primary Purpose:

Diagnostic

Official Title:

Effects of Propofol, Desflurane and Spinal Anesthesia on Intraocular Pressure During Lumbar Disc Herniation Surgery: A Randomized Controlled Study

Actual Study Start Date :

Jan 5, 2022

Actual Primary Completion Date :

Jan 2, 2023

Actual Study Completion Date :

May 15, 2023

Arms and Interventions

Arm	Intervention/Treatment
Active Comparator: Spinal Anesthesia Group Intraocular pressure values of the patients operated with spinal anaesthesia were measured	Other: Spinal Anesthesia Group Effect of spinal anesthesia on intraocular pressure
Active Comparator: Desflurane Group Intraocular pressure values were measured in patients operated under general anaesthesia with desflurane.	Other: Desflurane Group Effect of general anesthesia with desflurane on intraocular pressure
Active Comparator: Propofol Group Intraocular pressure values were measured in patients operated under general anaesthesia with desflurane.	Other: Propofol Group Effect of general anesthesia with propofol on intraocular pressure

Arm

Intervention/Treatment

Active Comparator: Spinal Anesthesia Group

Intraocular pressure values of the patients operated with spinal anaesthesia were measured

Other: Spinal Anesthesia Group

Effect of spinal anesthesia on intraocular pressure

Active Comparator: Desflurane Group

Intraocular pressure values were measured in patients operated under general anaesthesia with desflurane.

Other: Desflurane Group

Effect of general anesthesia with desflurane on intraocular pressure

Active Comparator: Propofol Group

Intraocular pressure values were measured in patients operated under general anaesthesia with desflurane.

Other: Propofol Group

Effect of general anesthesia with propofol on intraocular pressure

Outcome Measures

Primary Outcome Measures

intraocular pressure [Time 1:baseline supine , Time 2: 10. minute supine, Time 3: 20. minute prone , Time 4: 30. minute prone,Time 5: 10. minute after returning to the supine]
Intraocular pressure was measured a total of 5 times at set time points throughout the procedures.

Secondary Outcome Measures

Mean Arterial Pressure [Time 1:baseline supine , Time 2: 10. minute supine, Time 3: 20. minute prone , Time 4: 30. minute prone,Time 5: 10. minute after returning to the supine]
Mean Arterial Pressure was measured a total of 5 times at set time points throughout the procedures.
Heart Rate [Time 1:baseline supine , Time 2: 10. minute supine, Time 3: 20. minute prone , Time 4: 30. minute prone,Time 5: 10. minute after returning to the supine]
Heart Rate was measured a total of 5 times at set time points throughout the procedures.
End Tidal Carbon Dioxide (CO2) [Time 1:baseline supine , Time 2: 10. minute supine, Time 3: 20. minute prone , Time 4: 30. minute prone,Time 5: 10. minute after returning to the supine]
End Tidal CO2 was measured a total of 5 times at set time points throughout the procedures.