Dopamine Versus Norepinephrine Under General Anesthesia
Study Details
Study Description
Brief Summary
Participants under general anesthesia will be randomly treated with an adjusted dose dopamine or norepinephrine to elevate 10% of mean arterial pressure. Systemic hemodynamic data is recorded by PRAM and the change of cardiac index is compared between groups.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
| Phase 3 |
Detailed Description
After intubation under general anesthesia, radial arterial is cannulated and pressure transducer is connected to MostCare(core technique PRAM). CI, SVRI, SVI, SVV, dp/dt and HR are recorded before and after a infusion of dopamine or norepinephrine to elevate 10% of mean arterial pressure. Changes of these hemodynamic data are compared.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: norepinephrine infusion of norepinephrine with a adjusted dose to elevate 10% of mean arterial pressure |
Drug: norepinephrine
to treat hypotension under general anesthesia with norepinephrine
|
| Active Comparator: Dopamine infusion of dopamine with a adjusted dose to elevate 10% of mean arterial pressure |
Drug: dopamine
to treat hypotension under general anesthesia with dopamine
|
Outcome Measures
Primary Outcome Measures
- changes of cardiac index [20 minutes]
the differences of cardiac index between after and before the intervention (l/min/m2)
Secondary Outcome Measures
- changes of stroke volume index [20 minutes]
the differences of stroke volume index between after and before the intervention (ml/m2)
- changes of systemic vascular resistance index [20 minutes]
the differences of systemic vascular resistance index between after and before the intervention(dyne ∙ sec ∙ m2/cm5)
- changes of the maximal slope of systolic upstroke [20 minutes]
the differences of the maximal slope of systolic upstroke between after and before the intervention(mmHg/ms)
- changes of heart rate [20 minutes]
the differences of heart rate between after and before the intervention (bpm)
Eligibility Criteria
Criteria
Inclusion Criteria:
- undertake cardiac surgery for congenital heart disease
Exclusion Criteria:
-
Aortic valve or aortic disease
-
severe arrhythmia
-
use of cardiovascular active drugs before anesthesia
-
need to use a combination of different cardiovascular support drugs after anesthesia
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Children's Hospital of Fudan University | Shanghai | Shanghai | China | 200000 |
Sponsors and Collaborators
- Children's Hospital of Fudan University
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
- Cavigelli-Brunner A, Hug MI, Dave H, Baenziger O, Buerki C, Bettex D, Cannizzaro V, Balmer C. Prevention of Low Cardiac Output Syndrome After Pediatric Cardiac Surgery: A Double-Blind Randomized Clinical Pilot Study Comparing Dobutamine and Milrinone. Pediatr Crit Care Med. 2018 Jul;19(7):619-625. doi: 10.1097/PCC.0000000000001533.
- Foulon P, De Backer D. The hemodynamic effects of norepinephrine: far more than an increase in blood pressure! Ann Transl Med. 2018 Nov;6(Suppl 1):S25. doi: 10.21037/atm.2018.09.27.
- Saxena R, Durward A, Steeley S, Murdoch IA, Tibby SM. Predicting fluid responsiveness in 100 critically ill children: the effect of baseline contractility. Intensive Care Med. 2015 Dec;41(12):2161-9. doi: 10.1007/s00134-015-4075-8. Epub 2015 Sep 28.
- Yuan SM. Acute kidney injury after pediatric cardiac surgery. Pediatr Neonatol. 2019 Feb;60(1):3-11. doi: 10.1016/j.pedneo.2018.03.007. Epub 2018 Mar 30. Review.
- mzk-0003-2020