The Effects of Anesthetics on Brain Network Connectivity in Patients With Supratentorial Glioma
Study Details
Study Description
Brief Summary
Perioperative anesthesia can affect postoperative cognitive function. In our previous study, intraoperative dexmedetomidine (Dex) infusion reduced the incidence of delirium within the first 5 days after brain tumor. However, the mechanism is still unclear. With the development of neuroimaging, multimodal neuroimaging technology provide a new method to explore the underlying mechanism. Therefore, the purpose of this study is to analyze the alterations of brain network under sedation and anesthesia by different anesthetics in patients with supratentorial glioma and their association with cognition.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Dex group Participants will be sedated and maintained by dexmedetomidine. |
Drug: Dexmedetomidine
Participants will be sedated and maintained by dexmedetomidine during the surgery.
|
| Propofol group Participants will be sedated and maintained by propofol. |
Drug: Propofol
Participants will be sedated and maintained by propofol during the surgery.
|
Outcome Measures
Primary Outcome Measures
- The alterations of brain network connectivity. [Before sedation, 30 minutes after sedation，and 30 minutes after surgery.]
fMRI and DTI will be used to detect brain network connectivity.
Secondary Outcome Measures
- Postoperative delirium. [Day 1-5 after surgery.]
The incidence and severity of postoperative delirium and its association with changes of brain network connectivity.
- Electroencephalogram changes [From patients admission to operation room until 10 minutes after surgery]
Electroencephalogram will be used to record the brain activity.
- rScO2 changes. [From patients admission to operation room until 10 minutes after surgery]
Regional cerebral oxygen saturation (rScO2) will be monitored with near-infrared spectroscopy (NIRS).
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Diagnosed as unilateral supratentorial glioma by MRI
-
Selective operation
-
Age over 18 years old
-
ASA I-II
-
Right handedness
Exclusion Criteria:
-
History of cerebrovascular disease, brain trauma, chemotherapy and radiotherapy, or psychotropic drugs
-
History of intracranial surgery
-
Drug and/or alcohol abuse
-
History of dementia or mental illness
-
Pregnant or lactating women
-
Contraindications for MRI
-
Severe bradycardia (heart rate less than 40 beats per minute), sick sinus syndrome or second-to-third degree atrioventricular block
-
Severe hepatic or renal dysfunction
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Beijing Tian Tan Hospital, Capital Medical University | Beijing | Beijing | China | 100070 |
Sponsors and Collaborators
- Beijing Tiantan Hospital
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 20230808