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Angiography Derived Index of Microcirculatory Resistance in Patients With Acute Myocardial Infarction

Sponsor
Second Affiliated Hospital, School of Medicine, Zhejiang University (Other)
Overall Status
Completed
CT.gov ID
NCT05696379
Collaborator
Shengjing Hospital (Other), RenJi Hospital (Other)
5,000
Enrollment
1
Location
60
Actual Duration (Months)
83.4
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Coronary microcirculatory dysfunction has been known to be prevalent even after successful revascularization of acute myocardial infarction (AMI) patients, and has been shown to be associated with poor prognosis. Angiography derived index of micro-circulatory resistance (Angio-IMR) is a novel pressure-wire free approach to assess coronary microvascular disease with great diagnostic performance. The current study will further investigate the prognostic value of Angio-IMR in patients with AMI in multicenter retrospective cohort.

Condition or Disease Intervention/Treatment Phase
  • Other: Angiography derived index of micro-circulatory resistance (Angio-IMR)

Study Design

Study Type:
Observational
Actual Enrollment :
5000 participants
Observational Model:
Cohort
Time Perspective:
Retrospective
Official Title:
Angiography Derived Index of Microcirculatory Resistance in Patients With Acute Myocardial Infarction
Actual Study Start Date :
Jun 1, 2017
Actual Primary Completion Date :
May 31, 2022
Actual Study Completion Date :
May 31, 2022

Arms and Interventions

Arm Intervention/Treatment
STEMI with high Angio-IMR

Patients with ST segment elevation myocardial infarction and high Angio-IMR

Other: Angiography derived index of micro-circulatory resistance (Angio-IMR)
Angiography derived index of micro-circulatory resistance (Angio-IMR) post percutaneous coronary intervention.
STEMI with low Angio-IMR

Patients with ST segment elevation myocardial infarction and low Angio-IMR

Other: Angiography derived index of micro-circulatory resistance (Angio-IMR)
Angiography derived index of micro-circulatory resistance (Angio-IMR) post percutaneous coronary intervention.
NSTEMI with high Angio-IMR

Patients with non-ST segment elevation myocardial infarction and high Angio-IMR

Other: Angiography derived index of micro-circulatory resistance (Angio-IMR)
Angiography derived index of micro-circulatory resistance (Angio-IMR) post percutaneous coronary intervention.
NSTEMI with low Angio-IMR

Patients with non-ST segment elevation myocardial infarction and low Angio-IMR

Other: Angiography derived index of micro-circulatory resistance (Angio-IMR)
Angiography derived index of micro-circulatory resistance (Angio-IMR) post percutaneous coronary intervention.

Outcome Measures

Primary Outcome Measures

  1. Cardiac death or readmission for heart failure in 1 month [1 month]

    Incidence of cardiac death or readmission for heart failure during first 1 month follow-up.

  2. Cardiac death or readmission for heart failure in 6 months [6 month]

    Incidence of cardiac death or readmission for heart failure during first 6 months follow-up.

  3. Cardiac death or readmission for heart failure in 1 year [1 year]

    Incidence of cardiac death or readmission for heart failure during first 1 year follow-up.

  4. Cardiac death or readmission for heart failure in 2 years [2 year]

    Incidence of cardiac death or readmission for heart failure during first 2 years follow-up.

Eligibility Criteria

Criteria

Ages Eligible for Study:
18 Years and Older
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria:
  • Acute myocardial infarction patients who underwent successful percutaneous coronary intervention
Exclusion Criteria:

  • No appropriate coronary angiography images (inferior image quality, image loss, severe arteries overlap, or significant artifact)

  • Previous coronary artery bypass graft

Contacts and Locations

Locations

Site City State Country Postal Code
1 Second Affiliated Hospital, School of Medicine, Zhejiang University Hangzhou Zhejiang China 310009

Sponsors and Collaborators

  • Second Affiliated Hospital, School of Medicine, Zhejiang University
  • Shengjing Hospital
  • RenJi Hospital

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
Second Affiliated Hospital, School of Medicine, Zhejiang University
ClinicalTrials.gov Identifier:
NCT05696379
Other Study ID Numbers:
  • 2022-0878
First Posted:
Jan 25, 2023
Last Update Posted:
Jan 25, 2023
Last Verified:
Dec 1, 2022
Individual Participant Data (IPD) Sharing Statement:
No
Plan to Share IPD:
No
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Additional relevant MeSH terms:
Myocardial Infarction
Infarction

Study Results

No Results Posted as of Jan 25, 2023