Clincosm LogoSign in Get a demo

TMS Alteration of the Reward Positivity

Sponsor
University of New Mexico (Other)
Overall Status
Not yet recruiting
CT.gov ID
NCT05443256
Collaborator
(none)
8
Enrollment
2
Arms
11
Anticipated Duration (Months)

Study Details

Study Description

Brief Summary

The aim of this proposal is to demonstrate that stimulation of different brain regions differently affects the electroencephalographic feature known as the Reward Positivity (RewP).

Condition or Disease Intervention/Treatment Phase
  • Device: Transcranial Magnetic Stimulation
 N/A

Detailed Description

The aim of this proposal is to demonstrate that stimulation of different brain regions differently affects the electroencephalographic feature known as the Reward Positivity (RewP). The RewP is a sensitive and specific biomarker of reward receipt. This proposal will advance a causal test of the hypothesis that there are two major sources of variance that contribute to this brain response: a dorsal midline contribution to information encoding and a ventral midline contribution that is modulated by affect. Together, these findings will reveal how the RewP acts to blend multiple aspects of value together in the service of motivated learning. The objective of this proposal is to gather pilot data to demonstrate the feasibility of using transcranial magnetic stimulation (TMS) to perturb idiosyncratically-defined (fMRI-based) dorsal or ventral targets in order to causally test the hypothesis that these different sources contribute different types of variance to the RewP. TMS double cone deep coil stimulation should diminish +RPE encoding in the RewP when compared to sham. TMS Figure-8 coil stimulation should diminish affective modulation of RewP amplitude when compared to sham.

Study Design

Study Type:
Interventional
Anticipated Enrollment :
8 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Intervention Model Description:
Two separate arms of studyTwo separate arms of study
Masking:
Single (Participant)
Primary Purpose:
Other
Official Title:
Causal Dissociation of Value Contributions to the Reward Positivity
Anticipated Study Start Date :
Jul 1, 2022
Anticipated Primary Completion Date :
May 31, 2023
Anticipated Study Completion Date :
May 31, 2023

Arms and Interventions

Arm Intervention/Treatment
Experimental: Theta Stim

To stimulate fMRI-informed individualized targets in dlPFC to diminish affective modulation of the RewP. Based on our working hypothesis, TMS Figure-8 coil stimulation should diminish affective modulation of RewP amplitude when compared to sham.

Device: Transcranial Magnetic Stimulation
Figure 8 coil stimulation
Sham Comparator: Sham Stim

Sham stimulation. The Reward Positivity should be unaffected.

Device: Transcranial Magnetic Stimulation
Figure 8 coil stimulation

Outcome Measures

Primary Outcome Measures

  1. Reward Positivity [During intervention]

    EEG Amplitude 200-400 ms following reward receipt

Eligibility Criteria

Criteria

Ages Eligible for Study:
18 Years to 30 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
Yes
Inclusion Criteria:

• Men or women aged 18-30

Exclusion Criteria:

  • Participants unwilling or unable to give informed consent

  • Presence of other known medical or psychiatric comorbidity that in the investigator's opinion would compromise participation in the study

  • MEG/MRI contraindications

  • History of psychosis

  • Not fluent in English

Contacts and Locations

Locations

No locations specified.

Sponsors and Collaborators

  • University of New Mexico

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
James Cavanagh, Associate Professor, University of New Mexico
ClinicalTrials.gov Identifier:
NCT05443256
Other Study ID Numbers:
  • 20071
First Posted:
Jul 5, 2022
Last Update Posted:
Jul 8, 2022
Last Verified:
Jul 1, 2022
Individual Participant Data (IPD) Sharing Statement:
No
Plan to Share IPD:
No
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Product Manufactured in and Exported from the U.S.:
No
Additional relevant MeSH terms:
Anhedonia

Study Results

No Results Posted as of Jul 8, 2022