Creatine in Treating Patients With Cancer-Associated Weight Loss
Sponsor
Alliance for Clinical Trials in Oncology (Other)
Overall Status
Completed
CT.gov ID
NCT00081250
Collaborator
National Cancer Institute (NCI) (NIH)
300
220
2
151
1.4
0
Study Details
Study Description
Brief Summary
RATIONALE: It is not yet known whether the supplement creatine is effective in increasing weight and improving appetite and quality of life in patients who have cancer.
PURPOSE: This randomized phase III trial is studying how well creatine works in increasing weight and improving appetite and quality of life in patients with weight loss caused by cancer.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Phase 3 |
Detailed Description
OBJECTIVES:
-
Compare weight-gain effects of creatine vs placebo in patients with cancer-associated weight loss and/or anorexia.
-
Determine the effect of these regimens on quality of life in these patients.
-
Compare the toxic effects of these regimens in these patients.
-
Compare survival rates of patients treated with these regimens.
OUTLINE: This is a randomized, double-blind, placebo-controlled study. Patients are stratified according to primary cancer type (lung vs gastrointestinal vs other), weight loss severity (< 10 lbs vs ≥10 lbs), age (< 50 years vs ≥ 50 years), planned concurrent chemotherapy (yes vs no), gender, and prognosis. Patients are randomized to 1 of 2 treatment arms.
-
Arm I: Patients receive oral creatine daily.
-
Arm II: Patients receive oral placebo daily. In both arms, treatment continues in the absence of unacceptable toxicity as long as treatment is considered beneficial.
Patients are followed every 6 months for up to 5 years.
PROJECTED ACCRUAL: A total of 300 patients will be accrued for this study.
Study Design
Study Type:
Interventional
Anticipated Enrollment
:
300 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
Double (Participant, Investigator)
Primary Purpose:
Supportive Care
Official Title:
Phase III Double-Blind, Placebo-Controlled Randomized Comparison of Creatine for Cancer-Associated Weight Loss
Actual Study Start Date
:
Dec 1, 2004
Actual Primary Completion Date
:
Dec 1, 2007
Actual Study Completion Date
:
Jul 1, 2017
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Arm I Patients receive oral creatine daily. |
Dietary Supplement: creatine monohydrate
Given orally
|
| Placebo Comparator: Arm II Patients receive oral placebo daily. |
Other: placebo
Given orally
|
Outcome Measures
Primary Outcome Measures
- Percentage of patients who gain weight over 1 month [1 month]
Secondary Outcome Measures
- Percentage of patients who manifest weight stability (i.e., weight within 5% of baseline) at 1 month [1 month]
- Percentage of patients who manifest stability in appetite [Up to 5 years]
- Overall survival [Up to 5 years]
- Incidence of treatment-related toxicity [Up to 5 years]
- Quality of life [Up to 5 years]
Eligibility Criteria
Criteria
Ages Eligible for Study:
18 Years
and Older
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
DISEASE CHARACTERISTICS:
-
Histologically or cytologically confirmed cancer other than primary brain cancer
-
Considered incurable with available therapies
-
History of weight loss ≥ 5 lbs in 2 months or fewer AND/OR estimated intake of < 20 cal/kg daily
-
Determination by attending physician that weight gain would benefit patient
-
Perception by patient that weight loss is a problem
-
No symptomatic or untreated brain metastases
-
No clinical evidence of ascites
PATIENT CHARACTERISTICS:
Age
- 18 and over
Performance status
- ECOG 0-2
Life expectancy
- At least 3 months
Renal
- Creatinine normal
Cardiovascular
-
No poorly controlled congestive heart failure
-
No poorly controlled hypertension
Other
-
Able to reliably receive oral medication
-
Must be alert and mentally competent
-
No known obstruction of the alimentary tract, malabsorption, or intractable vomiting
-
No diabetes that is controlled by insulin
-
Not pregnant or nursing
-
Negative pregnancy test
-
Fertile patients must use effective contraception
PRIOR CONCURRENT THERAPY:
Chemotherapy
- Concurrent chemotherapy allowed
Endocrine therapy
-
No other concurrent adrenal corticosteroids, androgens, or progestational agents within 30 days after study entry
-
Concurrent short-term dexamethasone for chemotherapy-associated emesis is allowed
-
Concurrent inhalant, topical, or optical steroids allowed
Radiotherapy
-
No concurrent radiotherapy to the bowel or stomach
-
Other concurrent radiotherapy allowed
Other
-
No prior creatine use
-
No concurrent tube feedings or parenteral nutrition
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Mobile Infirmary Medical Center | Mobile | Alabama | United States | 36652-2144 |
| 2 | Mayo Clinic Scottsdale | Scottsdale | Arizona | United States | 85259-5499 |
| 3 | Aurora Presbyterian Hospital | Aurora | Colorado | United States | 80012 |
| 4 | Boulder Community Hospital | Boulder | Colorado | United States | 80301-9019 |
| 5 | Penrose Cancer Center at Penrose Hospital | Colorado Springs | Colorado | United States | 80933 |
| 6 | St. Anthony Central Hospital | Denver | Colorado | United States | 80204 |
| 7 | Porter Adventist Hospital | Denver | Colorado | United States | 80210 |
| 8 | Presbyterian - St. Luke's Medical Center | Denver | Colorado | United States | 80218 |
| 9 | St. Joseph Hospital | Denver | Colorado | United States | 80218 |
| 10 | Rose Medical Center | Denver | Colorado | United States | 80220 |
| 11 | CCOP - Colorado Cancer Research Program | Denver | Colorado | United States | 80224-2522 |
| 12 | Swedish Medical Center | Englewood | Colorado | United States | 80110 |
| 13 | St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center | Grand Junction | Colorado | United States | 81502 |
| 14 | North Colorado Medical Center | Greeley | Colorado | United States | 80631 |
| 15 | Sky Ridge Medical Center | Lone Tree | Colorado | United States | 80124 |
| 16 | Hope Cancer Care Center at Longmont United Hospital | Longmont | Colorado | United States | 80502 |
| 17 | McKee Medical Center | Loveland | Colorado | United States | 80539 |
| 18 | St. Mary - Corwin Regional Medical Center | Pueblo | Colorado | United States | 81004 |
| 19 | North Suburban Medical Center | Thornton | Colorado | United States | 80229 |
| 20 | Exempla Lutheran Medical Center | Wheat Ridge | Colorado | United States | 80033 |
| 21 | Mayo Clinic - Jacksonville | Jacksonville | Florida | United States | 32224 |
| 22 | MBCCOP - Medical College of Georgia Cancer Center | Augusta | Georgia | United States | 30912 |
| 23 | Tripler Army Medical Center | Honolulu | Hawaii | United States | 96859 |
| 24 | Rush-Copley Cancer Care Center | Aurora | Illinois | United States | 60507 |
| 25 | St. Joseph Medical Center | Bloomington | Illinois | United States | 61701 |
| 26 | Graham Hospital | Canton | Illinois | United States | 61520 |
| 27 | Memorial Hospital | Carthage | Illinois | United States | 62321 |
| 28 | Eureka Community Hospital | Eureka | Illinois | United States | 61530 |
| 29 | Galesburg Clinic, PC | Galesburg | Illinois | United States | 61401 |
| 30 | Galesburg Cottage Hospital | Galesburg | Illinois | United States | 61401 |
| 31 | Mason District Hospital | Havana | Illinois | United States | 62644 |
| 32 | Hopedale Medical Complex | Hopedale | Illinois | United States | 61747 |
| 33 | Joliet Oncology-Hematology Associates, Limited - West | Joliet | Illinois | United States | 60435 |
| 34 | Kewanee Hospital | Kewanee | Illinois | United States | 61443 |
| 35 | McDonough District Hospital | Macomb | Illinois | United States | 61455 |
| 36 | Trinity Cancer Center at Trinity Medical Center - 7th Street Campus | Moline | Illinois | United States | 61265 |
| 37 | Moline | Illinois | United States | 61265 | |
| 38 | BroMenn Regional Medical Center | Normal | Illinois | United States | 61761 |
| 39 | Community Cancer Center | Normal | Illinois | United States | 61761 |
| 40 | Community Hospital of Ottawa | Ottawa | Illinois | United States | 61350 |
| 41 | Oncology Hematology Associates of Central Illinois, PC - Ottawa | Ottawa | Illinois | United States | 61350 |
| 42 | Cancer Treatment Center at Pekin Hospital | Pekin | Illinois | United States | 61554 |
| 43 | Proctor Hospital | Peoria | Illinois | United States | 61614 |
| 44 | CCOP - Illinois Oncology Research Association | Peoria | Illinois | United States | 61615 |
| 45 | Oncology Hematology Associates of Central Illinois, PC - Peoria | Peoria | Illinois | United States | 61615 |
| 46 | Methodist Medical Center of Illinois | Peoria | Illinois | United States | 61636 |
| 47 | OSF St. Francis Medical Center | Peoria | Illinois | United States | 61637 |
| 48 | Illinois Valley Community Hospital | Peru | Illinois | United States | 61354 |
| 49 | Perry Memorial Hospital | Princeton | Illinois | United States | 61356 |
| 50 | St. Margaret's Hospital | Spring Valley | Illinois | United States | 61362 |
| 51 | Carle Cancer Center at Carle Foundation Hospital | Urbana | Illinois | United States | 61801 |
| 52 | CCOP - Carle Cancer Center | Urbana | Illinois | United States | 61801 |
| 53 | St. Francis Hospital and Health Centers - Beech Grove Campus | Beech Grove | Indiana | United States | 46107 |
| 54 | Elkhart General Hospital | Elkhart | Indiana | United States | 46515 |
| 55 | Howard Community Hospital | Kokomo | Indiana | United States | 46904 |
| 56 | Center for Cancer Therapy at LaPorte Hospital and Health Services | La Porte | Indiana | United States | 46350 |
| 57 | Saint Anthony Memorial Health Centers | Michigan City | Indiana | United States | 46360 |
| 58 | Reid Hospital & Health Care Services | Richmond | Indiana | United States | 47374 |
| 59 | CCOP - Northern Indiana CR Consortium | South Bend | Indiana | United States | 46601 |
| 60 | Memorial Hospital of South Bend | South Bend | Indiana | United States | 46601 |
| 61 | Saint Joseph Regional Medical Center | South Bend | Indiana | United States | 46617 |
| 62 | Bettendorf | Iowa | United States | 52722 | |
| 63 | Cedar Rapids Oncology Associates | Cedar Rapids | Iowa | United States | 52403 |
| 64 | Mercy Capitol Hospital | Des Moines | Iowa | United States | 50307 |
| 65 | CCOP - Iowa Oncology Research Association | Des Moines | Iowa | United States | 50309 |
| 66 | John Stoddard Cancer Center at Iowa Methodist Medical Center | Des Moines | Iowa | United States | 50309 |
| 67 | Medical Oncology and Hematology Associates at John Stoddard Cancer Center | Des Moines | Iowa | United States | 50309 |
| 68 | Medical Oncology and Hematology Associates at Mercy Cancer Center | Des Moines | Iowa | United States | 50314 |
| 69 | Mercy Cancer Center at Mercy Medical Center - Des Moines | Des Moines | Iowa | United States | 50314 |
| 70 | John Stoddard Cancer Center at Iowa Lutheran Hospital | Des Moines | Iowa | United States | 50316 |
| 71 | Mercy Cancer Center at Mercy Medical Center - North Iowa | Mason City | Iowa | United States | 50401 |
| 72 | McCreery Cancer Center at Ottumwa Regional | Ottumwa | Iowa | United States | 52501 |
| 73 | Siouxland Hematology-Oncology Associates, LLP | Sioux City | Iowa | United States | 51101 |
| 74 | Mercy Medical Center - Sioux City | Sioux City | Iowa | United States | 51104 |
| 75 | St. Luke's Regional Medical Center | Sioux City | Iowa | United States | 51104 |
| 76 | Cancer Center of Kansas, PA - Chanute | Chanute | Kansas | United States | 66720 |
| 77 | Cancer Center of Kansas, PA - Dodge City | Dodge City | Kansas | United States | 67801 |
| 78 | Cancer Center of Kansas, PA - El Dorado | El Dorado | Kansas | United States | 67042 |
| 79 | Cancer Center of Kansas, PA - Kingman | Kingman | Kansas | United States | 67068 |
| 80 | Southwest Medical Center | Liberal | Kansas | United States | 67901 |
| 81 | Cancer Center of Kansas, PA - Newton | Newton | Kansas | United States | 67114 |
| 82 | Cancer Center of Kansas, PA - Parsons | Parsons | Kansas | United States | 67357 |
| 83 | Cancer Center of Kansas, PA - Pratt | Pratt | Kansas | United States | 67124 |
| 84 | Cancer Center of Kansas, PA - Salina | Salina | Kansas | United States | 67042 |
| 85 | Cancer Center of Kansas, PA - Wellington | Wellington | Kansas | United States | 67152 |
| 86 | Associates in Womens Health, PA - North Review | Wichita | Kansas | United States | 67203 |
| 87 | Cancer Center of Kansas, PA - Medical Arts Tower | Wichita | Kansas | United States | 67208 |
| 88 | Cancer Center of Kansas, PA - Wichita | Wichita | Kansas | United States | 67214 |
| 89 | CCOP - Wichita | Wichita | Kansas | United States | 67214 |
| 90 | Via Christi Cancer Center at Via Christi Regional Medical Center | Wichita | Kansas | United States | 67214 |
| 91 | Cancer Center of Kansas, PA - Winfield | Winfield | Kansas | United States | 67156 |
| 92 | Ochsner Health Center - Bluebonnet | Baton Rouge | Louisiana | United States | 708169990 |
| 93 | Terrebonne General Medical Center | Houma | Louisiana | United States | 70360 |
| 94 | CCOP - Ochsner | New Orleans | Louisiana | United States | 70121 |
| 95 | Ochsner Cancer Institute at Ochsner Clinic Foundation | New Orleans | Louisiana | United States | 70121 |
| 96 | Hickman Cancer Center at Bixby Medical Center | Adrian | Michigan | United States | 49221 |
| 97 | Saint Joseph Mercy Cancer Center | Ann Arbor | Michigan | United States | 48106-0995 |
| 98 | CCOP - Michigan Cancer Research Consortium | Ann Arbor | Michigan | United States | 48106 |
| 99 | Oakwood Cancer Center at Oakwood Hospital and Medical Center | Dearborn | Michigan | United States | 48123-2500 |
| 100 | Genesys Hurley Cancer Institute | Flint | Michigan | United States | 48503 |
| 101 | Hurley Medical Center | Flint | Michigan | United States | 48503 |
| 102 | Van Elslander Cancer Center at St. John Hospital and Medical Center | Grosse Pointe Woods | Michigan | United States | 48236 |
| 103 | Foote Hospital | Jackson | Michigan | United States | 49201 |
| 104 | Haematology-Oncology Associates of Ohio and Michigan, PC | Lambertville | Michigan | United States | 48144 |
| 105 | Sparrow Regional Cancer Center | Lansing | Michigan | United States | 48912-1811 |
| 106 | Community Cancer Center of Monroe | Monroe | Michigan | United States | 48162 |
| 107 | Mercy Memorial Hospital - Monroe | Monroe | Michigan | United States | 48162 |
| 108 | Seton Cancer Institute - Saginaw | Saginaw | Michigan | United States | 48601 |
| 109 | Lakeland Regional Cancer Care Center - St. Joseph | Saint Joseph | Michigan | United States | 49085 |
| 110 | St. John Macomb Hospital | Warren | Michigan | United States | 48093 |
| 111 | MeritCare Bemidji | Bemidji | Minnesota | United States | 56601 |
| 112 | Fairview Ridges Hospital | Burnsville | Minnesota | United States | 55337 |
| 113 | Mercy and Unity Cancer Center at Mercy Hospital | Coon Rapids | Minnesota | United States | 55433 |
| 114 | Duluth Clinic Cancer Center - Duluth | Duluth | Minnesota | United States | 55805-1983 |
| 115 | CCOP - Duluth | Duluth | Minnesota | United States | 55805 |
| 116 | Miller - Dwan Medical Center | Duluth | Minnesota | United States | 55805 |
| 117 | Fairview Southdale Hospital | Edina | Minnesota | United States | 55435 |
| 118 | Mercy and Unity Cancer Center at Unity Hospital | Fridley | Minnesota | United States | 55432 |
| 119 | Immanuel St. Joseph's | Mankato | Minnesota | United States | 56002 |
| 120 | Minnesota Oncology Hematology, PA - Maplewood | Maplewood | Minnesota | United States | 55109 |
| 121 | Virginia Piper Cancer Institute at Abbott - Northwestern Hospital | Minneapolis | Minnesota | United States | 55407 |
| 122 | Hubert H. Humphrey Cancer Center at North Memorial Outpatient Center | Robbinsdale | Minnesota | United States | 55422-2900 |
| 123 | Mayo Clinic Cancer Center | Rochester | Minnesota | United States | 55905 |
| 124 | CCOP - Metro-Minnesota | Saint Louis Park | Minnesota | United States | 55416 |
| 125 | Park Nicollet Cancer Center | Saint Louis Park | Minnesota | United States | 55416 |
| 126 | United Hospital | Saint Paul | Minnesota | United States | 55102 |
| 127 | Ridgeview Medical Center | Waconia | Minnesota | United States | 55387 |
| 128 | Minnesota Oncology Hematology, PA - Woodbury | Woodbury | Minnesota | United States | 55125 |
| 129 | Hattiesburg Clinic, PA at Forrest General | Hattiesburg | Mississippi | United States | 39401 |
| 130 | Hematology & Oncology Clinic | Hattiesburg | Mississippi | United States | 39402 |
| 131 | Missouri Baptist Cancer Center | Saint Louis | Missouri | United States | 63131 |
| 132 | Arch Medical Services, Incorporated at Center for Cancer Care and Research | Saint Louis | Missouri | United States | 63141 |
| 133 | CCOP - Montana Cancer Consortium | Billings | Montana | United States | 59101 |
| 134 | Hematology-Oncology Centers of the Northern Rockies - Billings | Billings | Montana | United States | 59101 |
| 135 | Northern Rockies Radiation Oncology Center | Billings | Montana | United States | 59101 |
| 136 | St. Vincent Healthcare Cancer Care Services | Billings | Montana | United States | 59101 |
| 137 | Billings Clinic Cancer Center | Billings | Montana | United States | 59107-5100 |
| 138 | Billings Clinic - Downtown | Billings | Montana | United States | 59107-7000 |
| 139 | Bozeman Deaconess Cancer Center | Bozeman | Montana | United States | 59715 |
| 140 | St. James Healthcare Cancer Care | Butte | Montana | United States | 59701 |
| 141 | Big Sky Oncology | Great Falls | Montana | United States | 59405-5309 |
| 142 | Great Falls Clinic - Main Facility | Great Falls | Montana | United States | 59405 |
| 143 | Great Falls | Montana | United States | 59405 | |
| 144 | St. Peter's Hospital | Helena | Montana | United States | 59601 |
| 145 | Glacier Oncology, PLLC | Kalispell | Montana | United States | 59901 |
| 146 | Kalispell Medical Oncology at KRMC | Kalispell | Montana | United States | 59901 |
| 147 | Kalispell Regional Medical Center | Kalispell | Montana | United States | 59901 |
| 148 | Community Medical Center | Missoula | Montana | United States | 59801 |
| 149 | Guardian Oncology and Center for Wellness | Missoula | Montana | United States | 59804 |
| 150 | Montana Cancer Specialists at Montana Cancer Center | Missoula | Montana | United States | 59807-7877 |
| 151 | Montana Cancer Center at St. Patrick Hospital and Health Sciences Center | Missoula | Montana | United States | 59807 |
| 152 | Cancer Resource Center - Lincoln | Lincoln | Nebraska | United States | 68510 |
| 153 | CCOP - Missouri Valley Cancer Consortium | Omaha | Nebraska | United States | 68106 |
| 154 | Immanuel Medical Center | Omaha | Nebraska | United States | 68122 |
| 155 | Alegant Health Cancer Center at Bergan Mercy Medical Center | Omaha | Nebraska | United States | 68124 |
| 156 | Creighton University Medical Center | Omaha | Nebraska | United States | 68131-2197 |
| 157 | Bismarck Cancer Center | Bismarck | North Dakota | United States | 58501 |
| 158 | Medcenter One Hospital Cancer Care Center | Bismarck | North Dakota | United States | 58501 |
| 159 | Mid Dakota Clinic, PC | Bismarck | North Dakota | United States | 58501 |
| 160 | St. Alexius Medical Center Cancer Center | Bismarck | North Dakota | United States | 58502 |
| 161 | CCOP - MeritCare Hospital | Fargo | North Dakota | United States | 58122 |
| 162 | MeritCare Broadway | Fargo | North Dakota | United States | 58122 |
| 163 | Wood County Oncology Center | Bowling Green | Ohio | United States | 43402 |
| 164 | Adena Regional Medical Center | Chillicothe | Ohio | United States | 45601 |
| 165 | Riverside Methodist Hospital Cancer Care | Columbus | Ohio | United States | 43214-3998 |
| 166 | CCOP - Columbus | Columbus | Ohio | United States | 43215 |
| 167 | Grant Medical Center Cancer Care | Columbus | Ohio | United States | 43215 |
| 168 | Mount Carmel Health - West Hospital | Columbus | Ohio | United States | 43222 |
| 169 | Doctors Hospital at Ohio Health | Columbus | Ohio | United States | 43228 |
| 170 | Grandview Hospital | Dayton | Ohio | United States | 45405 |
| 171 | Good Samaritan Hospital | Dayton | Ohio | United States | 45406 |
| 172 | David L. Rike Cancer Center at Miami Valley Hospital | Dayton | Ohio | United States | 45409 |
| 173 | Samaritan North Cancer Care Center | Dayton | Ohio | United States | 45415 |
| 174 | Veterans Affairs Medical Center - Dayton | Dayton | Ohio | United States | 45428 |
| 175 | CCOP - Dayton | Dayton | Ohio | United States | 45429 |
| 176 | Grady Memorial Hospital | Delaware | Ohio | United States | 43015 |
| 177 | Blanchard Valley Medical Associates | Findlay | Ohio | United States | 45840 |
| 178 | Fremont Memorial Hospital | Fremont | Ohio | United States | 43420 |
| 179 | Charles F. Kettering Memorial Hospital | Kettering | Ohio | United States | 45429 |
| 180 | Fairfield Medical Center | Lancaster | Ohio | United States | 43130 |
| 181 | Lima Memorial Hospital | Lima | Ohio | United States | 45804 |
| 182 | Strecker Cancer Center at Marietta Memorial Hospital | Marietta | Ohio | United States | 45750 |
| 183 | Northwest Ohio Oncology Center | Maumee | Ohio | United States | 43537 |
| 184 | St. Luke's Hospital | Maumee | Ohio | United States | 43537 |
| 185 | Middletown Regional Hospital | Middletown | Ohio | United States | 45044 |
| 186 | Licking Memorial Cancer Care Program at Licking Memorial Hospital | Newark | Ohio | United States | 43055 |
| 187 | St. Charles Mercy Hospital | Oregon | Ohio | United States | 43616 |
| 188 | Toledo Clinic - Oregon | Oregon | Ohio | United States | 43616 |
| 189 | Firelands Regional Medical Center | Sandusky | Ohio | United States | 44870 |
| 190 | North Coast Cancer Care, Incorporated | Sandusky | Ohio | United States | 44870 |
| 191 | Mercy Medical Center | Springfield | Ohio | United States | 45504 |
| 192 | Community Hospital of Springfield and Clark County | Springfield | Ohio | United States | 45505 |
| 193 | Flower Hospital Cancer Center | Sylvania | Ohio | United States | 43560 |
| 194 | Mercy Hospital of Tiffin | Tiffin | Ohio | United States | 44883 |
| 195 | Toledo Hospital | Toledo | Ohio | United States | 43606 |
| 196 | St. Vincent Mercy Medical Center | Toledo | Ohio | United States | 43608 |
| 197 | Medical University of Ohio Cancer Center | Toledo | Ohio | United States | 43614 |
| 198 | CCOP - Toledo Community Hospital | Toledo | Ohio | United States | 43617 |
| 199 | Toledo Clinic, Incorporated - Main Clinic | Toledo | Ohio | United States | 43623 |
| 200 | UVMC Cancer Care Center at Upper Valley Medical Center | Troy | Ohio | United States | 45373-1300 |
| 201 | Fulton County Health Center | Wauseon | Ohio | United States | 43567 |
| 202 | Mount Carmel St. Ann's Cancer Center | Westerville | Ohio | United States | 43081 |
| 203 | United States Air Force Medical Center - Wright-Patterson | Wright-Patterson Air Force Base | Ohio | United States | 45433-5529 |
| 204 | Ruth G. McMillan Cancer Center at Greene Memorial Hospital | Xenia | Ohio | United States | 45385 |
| 205 | Genesis - Good Samaritan Hospital | Zanesville | Ohio | United States | 43701 |
| 206 | Natalie Warren Bryant Cancer Center at St. Francis Hospital | Tulsa | Oklahoma | United States | 74136 |
| 207 | Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest | Allentown | Pennsylvania | United States | 18105 |
| 208 | Geisinger Medical Center | Danville | Pennsylvania | United States | 17822-0001 |
| 209 | Geisinger Medical Group - Scenery Park | State College | Pennsylvania | United States | 16801 |
| 210 | Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center | Wilkes-Barre | Pennsylvania | United States | 18711 |
| 211 | Avera Cancer Institute | Sioux Falls | South Dakota | United States | 57105 |
| 212 | Medical X-Ray Center, PC | Sioux Falls | South Dakota | United States | 57105 |
| 213 | Sanford Cancer Center at Sanford USD Medical Center | Sioux Falls | South Dakota | United States | 57117-5039 |
| 214 | Fredericksburg Oncology, Incorporated | Fredericksburg | Virginia | United States | 22401 |
| 215 | Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center | Green Bay | Wisconsin | United States | 54301-3526 |
| 216 | Green Bay Oncology, Limited at St. Mary's Hospital | Green Bay | Wisconsin | United States | 54303 |
| 217 | St. Mary's Hospital Medical Center - Green Bay | Green Bay | Wisconsin | United States | 54303 |
| 218 | St. Vincent Hospital Regional Cancer Center | Green Bay | Wisconsin | United States | 54307-3508 |
| 219 | Bay Area Cancer Care Center at Bay Area Medical Center | Marinette | Wisconsin | United States | 54143 |
| 220 | Welch Cancer Center at Sheridan Memorial Hospital | Sheridan | Wyoming | United States | 82801 |
Sponsors and Collaborators
- Alliance for Clinical Trials in Oncology
- National Cancer Institute (NCI)
Investigators
- Study Chair: Aminah Jatoi, MD, Mayo Clinic
Study Documents (Full-Text)
None provided.More Information
Additional Information:
Publications
None provided.Responsible Party:
Alliance for Clinical Trials in Oncology
ClinicalTrials.gov Identifier:
NCT00081250
Other Study ID Numbers:
- NCCTG-N02C4
- NCI-2012-02584
- CDR0000360798
First Posted:
Apr 8, 2004
Last Update Posted:
Apr 29, 2020
Last Verified:
Apr 1, 2020
Keywords provided by Alliance for Clinical Trials in Oncology
Additional relevant MeSH terms: