ATENA-F: Anterior Temporal Epilepsy Neuropsychological Assessment of Faces
Study Details
Study Description
Brief Summary
The purpose is to evaluate neuropsychological effects of anterior temporal epilepsy in face perception by comparison of performances of epileptic patients and control individuals, sex-, age- and socio-educational level-matched.
Secondary purposes are to prospectively evaluate neuropsychological impact of anterior temporal lobectomy performed for surgical treatment of anterior temporal epilepsy on face perception (exploratory study).
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Other: Epilepsy Patients do face specific tests during conventional pre-lobectomy intercritical assessment hospitalization (inclusion, day 0) and after 6 and 18 months from anterior temporal lobectomy |
Other: Mooney test
Other: Benton Face Recognition test
Other: Face inversion effect test
Other: Face composite effect test
Other: Cambridge Face Memory Test
Other: Matching different view test
Other: Memorizing and recognition of new faces test
Other: Memorizing and recognition of new objects test
Other: Recognition of celebrities and access to semantic information test
Procedure: Lobectomy
In patients with anterior temporal epilepsy, at 6 to 12 months after inclusion, depending on surgery decision taken after pre-surgery conventional intercritical assessment
|
| Other: Control Control individuals do face specific tests during inclusion visit (day 0) and after X months (X = time from day 0 and lobectomy of matched patient + 6 months) |
Other: Mooney test
Other: Benton Face Recognition test
Other: Face inversion effect test
Other: Face composite effect test
Other: Cambridge Face Memory Test
Other: Matching different view test
Other: Memorizing and recognition of new faces test
Other: Memorizing and recognition of new objects test
Other: Recognition of celebrities and access to semantic information test
|
Outcome Measures
Primary Outcome Measures
- Scores obtained with Benton test by patients with anterior temporal epilepsy and matched control individuals [day 0]
Secondary Outcome Measures
- Change of scores obtained with Benton test by epilepsy patients before and after lobectomy and control individuals (only patients having undergone anterior temporal lobectomy and matched control individuals) [day 0 and after 12 to 18 months]
- Change of scores obtained with Benton test by epilepsy patients before and after lobectomy and control individuals (only patients having undergone anterior temporal lobectomy and matched control individuals) [day 0 and after 24 to 30 months]
Eligibility Criteria
Criteria
Inclusion Criteria:
ALL:
-
Informed consent
-
Affiliation to social security
-
Preliminary medical examination
PATIENTS WITH EPILEPSY:
-
Symptomatic drug-resistant anterior temporal epilepsy (confirmed with video-electroencephalography and magnetic resonance imaging and if necessary intracerebral SEEG exploration)
-
Patient needing anterior temporal lobectomy and undergoing pre-surgery conventional intercritical assessment for surgery decision
-
Nonverbal IQ ≥ 70 (WAIS-IV)
-
At least 6 successful VOSP tests (perception test)
Exclusion Criteria:
ALL:
-
persons under legal protection or incapable to consent
-
Persons deprived of liberty by juridical or administrative decision
PATIENTS WITH EPILEPSY:
- Sever visual disorders of neurological or ophthalmological origin
CONTROL INDIVIDUALS:
-
Psychiatric or neurological disorders
-
Important ophthalmological disorders
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Service de Neurologie, Hôpital Central, CHU de Nancy | Nancy | France |
Sponsors and Collaborators
- Central Hospital, Nancy, France
Investigators
- Principal Investigator: Louis Maillard, Service de Neurologie, Hôpital Central, CHU de Nancy, France
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 2013-A00515-40