Anthropometric, Metabolic, Cardiovascular and Symptomatic Profile in Postmenopausal Women
Study Details
Study Description
Brief Summary
The purpose of this study is to investigate anthropometric, metabolic, cardiovascular and symptomatic profiles in postmenopausal women.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
When aging, the body composition changes, leading to a reduction of muscle mass and strength, and to an increase in total body fat. These body composition changes have especially been observed in postmenopausal women, due to the hormonal changes taking place. After the menopause, the gynoid fat distribution with fat deposits in the gluteo-femoral region changes to an android fat distribution with an increased upper body fat, especially in the abdominal region. These consequences of the menopause associated with a decrease in aerobic capacity and reduced total energy expenditure may lead to the metabolic syndrome (MetS). The aim of this study was to investigate the anthropometric, metabolic, cardiovascular and symptomatic profile in gynoid and android postmenopausal women.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| android postmenopausal women Clinical exams |
Other: Clinical exams
Physiological and biochemical tests; quality of life questionnaire; body composition measurement
|
| gynoid postmenopausal women Clinical exams |
Other: Clinical exams
Physiological and biochemical tests; quality of life questionnaire; body composition measurement
|
Outcome Measures
Primary Outcome Measures
- Relationships between postmenopause and fat distribution [Baseline]
Anthropometric measurements: waist-to-hip ratio and body mass index
Secondary Outcome Measures
- Comparison of aerobic capacity between android and gynoid postmenopausal women [Baseline]
Progressive aerobic testing on treadmill (Modified Bruce Protocol): estimated maximum oxygen consumption; metabolic equivalents; blood pressure; heart rate
- Comparison of metabolic parameters between android and gynoid postmenopausal women [Baseline]
Biochemical tests: the serum level of estradiol, urea, creatinine, triglycerides, total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, very low-density lipoprotein (VLDL) cholesterol, insulin and glucose
- Comparison of quality of life between android and gynoid postmenopausal women [Baseline]
Menopause Rating Scale (MRS): somatic symptoms; psychological symptoms; urogenital-sexual problems
- Comparison of the body composition between android and gynoid postmenopausal women [Baseline]
Body composition: bipolar electrical bioimpedance (body fat and lean mass) and skinfolds (triceps, subscapular, suprailiac, abdominal, anterior thigh, medial calf)
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Postmenopausal women
-
Caucasian
-
50-60 years of age
Exclusion Criteria:
-
Neurological disease
-
Pulmonary disease
-
Cardiac disease
-
Oncological disease
-
Musculotendinous or articular injuries
-
Hormone replacement therapy
-
Cigarette smoking
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Optics Group from Physics Institute of São Carlos (IFSC), University of São Paulo (USP) | São Carlos | São Paulo | Brazil | 676 |
Sponsors and Collaborators
- University of Sao Paulo
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.
Investigators
- Study Director: Audrey Borghi-Silva, Ph.D, Department of Physical Therapy, Federal University of São Carlos (UFSCar)
- Study Director: Cristina Kurachi, Ph.D, Physics Institute of São Carlos (IFSC), University of São Paulo (USP)
- Study Director: Vanderlei S Bagnato, Ph.D, Physics Institute of São Carlos (IFSC), University of São Paulo (USP)
- Principal Investigator: Fernanda R. Paolillo, Ph.D, Physics Institute of São Carlos (IFSC), University of São Paulo (USP)
Study Documents (Full-Text)
None provided.More Information
Publications
- Blümel JE, Legorreta D, Chedraui P, Ayala F, Bencosme A, Danckers L, Lange D, Espinoza MT, Gomez G, Grandia E, Izaguirre H, Manriquez V, Martino M, Navarro D, Ojeda E, Onatra W, Pozzo E, Prada M, Royer M, Saavedra JM, Sayegh F, Tserotas K, Vallejo MS, Zuñiga C; Collaborative Group for Research of the Climacteric in Latin America (REDLINC). Optimal waist circumference cutoff value for defining the metabolic syndrome in postmenopausal Latin American women. Menopause. 2012 Apr;19(4):433-7. doi: 10.1097/gme.0b013e318231fc79.
- Després JP, Lemieux I. Abdominal obesity and metabolic syndrome. Nature. 2006 Dec 14;444(7121):881-7. Review.
- Paolillo FR, Corazza AV, Borghi-Silva A, Parizotto NA, Kurachi C, Bagnato VS. Infrared LED irradiation applied during high-intensity treadmill training improves maximal exercise tolerance in postmenopausal women: a 6-month longitudinal study. Lasers Med Sci. 2013 Feb;28(2):415-22. doi: 10.1007/s10103-012-1062-y. Epub 2012 Mar 2.
- Paolillo FR, Milan JC, Aniceto IV, Barreto SG, Rebelatto JR, Borghi-Silva A, Parizotto NA, Kurachi C, Bagnato VS. Effects of infrared-LED illumination applied during high-intensity treadmill training in postmenopausal women. Photomed Laser Surg. 2011 Sep;29(9):639-45. doi: 10.1089/pho.2010.2961. Epub 2011 Jul 12.
- Paolillo FR, Milan JC, Bueno Pde G, Paolillo AR, Borghi-Silva A, Parizotto NA, Arena R, Kurachi C, Bagnato VS. Effects of excess body mass on strength and fatigability of quadriceps in postmenopausal women. Menopause. 2012 May;19(5):556-61. doi: 10.1097/gme.0b013e3182364e80.
- 150949/2011-1