ALPHA: Assessing Visual Processing in High Anxiety
Study Details
Study Description
Brief Summary
High trait anxiety, a stable personality trait, is a risk factor for psychiatric disorders. Individuals with high trait anxiety have difficulty differentiating safety from threat, including visual information like emotional faces. This study aims to characterize visual system function in high trait anxiety. A portion of this study involves an intervention. For the intervention portion, a subset of participants will be asked to return for a lab visit upon completing the first portion of the study (multimodal magnetic resonance imaging (MRI) scan). During this follow up visit, participants will complete a computer task that involves looking at faces and identifying emotions. Participants will complete this task either six months or twelve months after their MRI scan visit. Results from this research have the potential to inform novel therapies that target the visual system in individuals at risk for the development of psychiatric disorders.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
The purpose of this study is to understand how people with anxious personalities process emotional facial expressions. The intervention portion of this study is part of a larger study. The first portion of this study consists of a screening visit with questionnaires, and a second visit with a magnetic resonance imaging (MRI) scan and short computer tasks.
For the intervention portion of this study, a subset of participants will return to the lab for an in-person visit either six or twelve months after their MRI scan. This visit will last approximately two hours. Participants will be asked to complete a computer task where they will be asked to identify emotional face expressions and receive feedback on their performance. They will also complete questionnaires about their mood and emotions.
The primary purpose of this research is to gather scientific information about how people with anxiety process social and emotional information.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: 6 Month Micro Expression Training Task The Micro Expression Training Task (METT) presents videos of subtle emotional face expressions; participants receive real-time feedback following forced choice emotional identification. The METT includes a brief pre-test, training, and then a post-test. |
Behavioral: Facial Microexpression Training
The METT is a well-validated task designed to improve perception of subtle changes in facial expressions, termed microexpressions. Participants with high trait anxiety will return to the lab approximately six months post scan visit to complete this computer-based task. They will receive feedback during the task on their accuracy.
|
| Experimental: 12 Month Micro Expression Training Task The Micro Expression Training Task (METT) presents videos of subtle emotional face expressions; participants receive real-time feedback following forced choice emotional identification. The METT includes a brief pre-test, training, and then a post-test. Participants in this group will complete this task twelve month after their first visit. |
Behavioral: Facial Microexpression Training
The METT is a well-validated task designed to improve perception of subtle changes in facial expressions, termed microexpressions. Participants with high trait anxiety will return to the lab approximately six months post scan visit to complete this computer-based task. They will receive feedback during the task on their accuracy.
|
Outcome Measures
Primary Outcome Measures
- Tolerability of the Micro Expression Training Task in individuals with high anxiety [six or twelve months post-scan visit]
Rates of completion of the behavioral task
Eligibility Criteria
Criteria
Inclusion Criteria:
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Young adults varying continuously in trait anxiety as assessed by the Spielberger State Trait Anxiety Inventory (STAI).
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HTA participants with STAI trait scores of ≥44
Exclusion Criteria:
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contraindication to MRI
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history of head trauma or loss of consciousness
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major medical or neurological illness
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current psychiatric medication usage or use in the last three months
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alcohol/substance abuse or dependence and/or illicit substance use (excepting cannabis) in the last three months
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | University of Pittsburgh | Pittsburgh | Pennsylvania | United States | 15213 |
Sponsors and Collaborators
- University of Pittsburgh
- National Institute of Mental Health (NIMH)
Investigators
- Principal Investigator: Elliot K Edmiston, PhD, Assistant Professor
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- STUDY19010289
- 1K01MH117290-01A1