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Aortic Dimensions in Turner Syndrome

Sponsor
University of Aarhus (Other)
Overall Status
Unknown status
CT.gov ID
NCT00624949
Collaborator
(none)
102
Enrollment
106
Duration (Months)

Study Details

Study Description

Brief Summary

An observational study of 102 women with Turner syndrome followed for 6 years with a two-yearly examination including ECHO, MRI of the heart and 24 ambulatory blood pressure. It has been found that besides an significantly increased risk of congenital cardiac malformations, TS have an increased risk of developing cardiac disease including the life threatening condition of aortic dilatation and rupture. The aim of the study is to describe the cardiac conditions of TS, evaluate different methods of examination and identify possible risc factors.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    102 participants
    Observational Model:
    Cohort
    Time Perspective:
    Prospective
    Official Title:
    Aortic Dimensions, 24hour Ambulatory Blood Pressure and Sympathovagal Tone in Turner Syndrome. In Relation to Aortic Dilatation and Dissection.
    Study Start Date :
    Aug 1, 2003
    Anticipated Primary Completion Date :
    Jun 1, 2012
    Anticipated Study Completion Date :
    Jun 1, 2012

    Arms and Interventions

    Arm Intervention/Treatment
    1

    women with Turner syndrome
    2.

    Control women

    Outcome Measures

    Primary Outcome Measures

    1. Aortic diameter at 3 well-defined levels measured by MRI and ECHO [2-yearly for 6 years]

    Secondary Outcome Measures

    1. 24hour ambulatory blood pressure [24h 2-yearly for 6 years]

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years to 70 Years
    Sexes Eligible for Study:
    Female
    Accepts Healthy Volunteers:
    Yes
    Inclusion Criteria:

    • Turner syndrome

    • Age 18-70 years

    Exclusion Criteria:

    • Extreme adipositas

    • Contraindications to a MRI scan

    • Malignant disease

    Contacts and Locations

    Locations

    No locations specified.

    Sponsors and Collaborators

    • University of Aarhus

    Investigators

    None specified.

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    , ,
    ClinicalTrials.gov Identifier:
    NCT00624949
    Other Study ID Numbers:
    • 20010248
    First Posted:
    Feb 28, 2008
    Last Update Posted:
    Feb 28, 2008
    Last Verified:
    Feb 1, 2008
    Keywords provided by , ,
    Turner syndrome
    aortic dimensions
    blood pressure
    aortic dilatation
    aortic rupture
    Additional relevant MeSH terms:
    Turner Syndrome
    Gonadal Dysgenesis
    Syndrome

    Study Results

    No Results Posted as of Feb 28, 2008