Clinical Characteristics, Management Patterns and Outcomes of Type A Aortic Dissection: A Sino-US Comparative Cohort Analysis

• Sponsor: Xin Chen (Other)
• Overall Status: Completed
• CT.gov ID: NCT05409469
• Collaborator: China Medical University, China (Other)
• Enrollment: 11,550
• Actual Duration (Months): 119

Study Details

Study Description

Brief Summary

This study constructed a retrospective cohort study by retrospectively analyzing the data of all patients with aortic dissection from January 1, 2012 to December 31, 2021 from the Cardiovascular Disease Registration System of Jiangsu Province in China and the data of similar diseases in recent years from National Inpatient Sample database in the United States

Condition or Disease	Intervention/Treatment	Phase
Aortic Dissection	Procedure: surgery

Study Design

• Study Type: Observational [Patient Registry]
• Actual Enrollment: 11550 participants
• Observational Model: Cohort
• Time Perspective: Other
• Official Title: Clinical Characteristics, Management Patterns and Outcomes of Type A Aortic Dissection: A Sino-US Comparative Cohort Analysis
• Actual Study Start Date: Jan 1, 2012
• Actual Primary Completion Date: Dec 1, 2021
• Actual Study Completion Date: Dec 1, 2021

Arms and Interventions

Arm	Intervention/Treatment
Chinese patients with aortic dissection Clinical characteristics, management patterns and outcomes of type A aortic dissection in China.	Procedure: surgery; surgery on patients with aortic dissection
American patients with aortic dissection Clinical characteristics, management patterns and outcomes of type A aortic dissection in the United States.	Procedure: surgery; surgery on patients with aortic dissection

Outcome Measures

Primary Outcome Measures

1. Baseline data of patients with type A aortic dissection was assessed by SPSS 17.0 [from 2015 to 2019]

   Baseline data of patients with type A aortic dissection included gender, age,height, weight, past medical history, family history, hospital costs, etc.

2. The main efficacy indicators was assessed by SPSS 17.0. [from 2015 to 2019]

   The main efficacy indicators included surgical procedures, surgical outcome (postoperative bleeding, ICU stay, extubation time), perioperative complications (including infection, bleeding, neurological complications, cardic complications, renal insufficiency, etc.), and postoperative mortality.

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years and Older
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Inclusion Criteria:

1.Clinical diagnosis of type A Aortic Dissection

Exclusion Criteria:

1. age<18, age unknown,

2. diagnosis of aortic aneurysm, transfer out within 1 day,

3. unknown vital status at discharge;

4. unknown treatment type: cardioplegia, valve or cardiac repair only without aortic repair or two types of treatments on different days

Contacts and Locations

Locations

No locations specified.

Sponsors and Collaborators

• Xin Chen
• China Medical University, China

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: Xin Chen, Clinical Professor, Nanjing First Hospital, Nanjing Medical University
• ClinicalTrials.gov Identifier: NCT05409469
• Other Study ID Numbers: NanjingFirst AAD
• First Posted: Jun 8, 2022
• Last Update Posted: Jun 8, 2022
• Last Verified: May 1, 2022

• Individual Participant Data (IPD) Sharing Statement: No
• Plan to Share IPD: No
• Studies a U.S. FDA-regulated Drug Product: No
• Studies a U.S. FDA-regulated Device Product: No
• Keywords provided by Xin Chen, Clinical Professor, Nanjing First Hospital, Nanjing Medical University: Aortic Dissection; China; the United States
• Additional relevant MeSH terms: Aneurysm, Dissecting

Study Results

No Results Posted as of Jun 8, 2022