ECOCAPTURE: Quantitative Evaluation of Apathy Close to Real Life Situation by Means of a Multimodal Sensor System Integrated.
Study Details
Study Description
Brief Summary
The purpose of this study is to provide relevant quantitative evaluation of apathy close to real life situation by means of a multimodal sensor system integrated.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
The investigators try to measure the amount of goal-directed behaviour and to detect the pattern of apathy. The main objective of this pilot phase is to select the variables of goal-directed behaviour from the list of metrics providing by the multimodal acquisition system in healthy subjects and patients with frontotemporal dementia.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: ECOCAPTURE Quantitative Evaluation of Apathy Close to Real Life Situation by Means of a Multimodal Sensor System Integrated. |
Behavioral: Evaluation of Apathy Close to Real Life Situation
Quantitative Evaluation of Apathy Close to Real Life Situation by Means of a Multimodal Sensor System Integrated.
|
Outcome Measures
Primary Outcome Measures
- Occurrence of each behavior from the ethogram [45 min]
[Provided by the video recording and The Observer NOLDUS software]
- Frequency of each behavior from the ethogram [45 min]
[Provided by the video recording and The Observer NOLDUS software]
- Duration of each behavior from the ethogram [45 mn]
[Provided by the video recording and The Observer NOLDUS software]
- Number of different behaviors [45 mn]
[Provided by the video recording and The Observer NOLDUS software]
- Activity classes [45 mn]
[Provided by the MOVE MOVISENS sensor] lying, sitting, ...
- Body positions [45 mn]
[Provided by the MOVE MOVISENS sensor] lying left, ...
- Energy expenditure [45 mn]
[Provided by the MOVE MOVISENS sensor] kcal.
- MET [45 mn]
[Provided by the MOVE MOVISENS sensor] The Metabolic Equivalent of Task. MET level.
- Steps [45 mn]
[Provided by the MOVE MOVISENS sensor] Counting steps.
- Activity intensity [45 mn]
[Provided by the MOVE MOVISENS sensor] g.
Eligibility Criteria
Criteria
Inclusion Criteria:
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Diagnosis of Frontotemporal Dementia (FTD) according to diagnostic criteria reported by Rascovsky et al. (2011).
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Understanding of the instructions and capacity to realize the cognitive tasks.
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Capacity to read, to understand and to sign legal document of information
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Capacity for informed consent for research, capacity to sign consent
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MMSE score > 20
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Absence of other cerebral pathology.
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Absence of psychiatric disease interfering with the assessment of the tests
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Absence of excessive psychotropic use
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Access to National Healthcare Insurance
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Accompanied with a caregiver
Exclusion Criteria:
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Excessive psychotropic use
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Incapacity or refusal to realize the experimental tasks
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Subject deprived of freedom by an administrative or court order
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Subject under legal protective measure.
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Incapacity for informed consent for research
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Participation in another biomedical research
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Airway obstruction risk
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Reduction of activity not attributable to another chronic pathological condition
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- Institut National de la Santé Et de la Recherche Médicale, France
Investigators
- Principal Investigator: Richard LEVY, PhD, MD, INSERM UMR_S 1127, ICM
Study Documents (Full-Text)
None provided.More Information
Publications
- Brown RG, Pluck G. Negative symptoms: the 'pathology' of motivation and goal-directed behaviour. Trends Neurosci. 2000 Sep;23(9):412-7. Review.
- Czernecki V, Pillon B, Houeto JL, Welter ML, Mesnage V, Agid Y, Dubois B. Does bilateral stimulation of the subthalamic nucleus aggravate apathy in Parkinson's disease? J Neurol Neurosurg Psychiatry. 2005 Jun;76(6):775-9.
- Dujardin K, Sockeel P, Delliaux M, Destée A, Defebvre L. The Lille Apathy Rating Scale: validation of a caregiver-based version. Mov Disord. 2008 Apr 30;23(6):845-9. doi: 10.1002/mds.21968.
- Funkiewiez A, Bertoux M, de Souza LC, Lévy R, Dubois B. The SEA (Social cognition and Emotional Assessment): a clinical neuropsychological tool for early diagnosis of frontal variant of frontotemporal lobar degeneration. Neuropsychology. 2012 Jan;26(1):81-90. doi: 10.1037/a0025318. Epub 2011 Sep 5.
- Lane-Brown AT, Tate RL. Apathy after acquired brain impairment: a systematic review of non-pharmacological interventions. Neuropsychol Rehabil. 2009 Aug;19(4):481-516. doi: 10.1080/09602010902949207. Review.
- Le Jeune F, Drapier D, Bourguignon A, Péron J, Mesbah H, Drapier S, Sauleau P, Haegelen C, Travers D, Garin E, Malbert CH, Millet B, Vérin M. Subthalamic nucleus stimulation in Parkinson disease induces apathy: a PET study. Neurology. 2009 Nov 24;73(21):1746-51. doi: 10.1212/WNL.0b013e3181c34b34.
- Levy R, Czernecki V. Apathy and the basal ganglia. J Neurol. 2006 Dec;253 Suppl 7:VII54-61. Review.
- Levy R, Dubois B. Apathy and the functional anatomy of the prefrontal cortex-basal ganglia circuits. Cereb Cortex. 2006 Jul;16(7):916-28. Epub 2005 Oct 5. Review.
- Marin RS, Firinciogullari S, Biedrzycki RC. Group differences in the relationship between apathy and depression. J Nerv Ment Dis. 1994 Apr;182(4):235-9.
- Marin RS. Apathy: a neuropsychiatric syndrome. J Neuropsychiatry Clin Neurosci. 1991 Summer;3(3):243-54. Review.
- Mayo NE, Fellows LK, Scott SC, Cameron J, Wood-Dauphinee S. A longitudinal view of apathy and its impact after stroke. Stroke. 2009 Oct;40(10):3299-307. doi: 10.1161/STROKEAHA.109.554410. Epub 2009 Aug 27.
- Müller U, Czymmek J, Thöne-Otto A, Von Cramon DY. Reduced daytime activity in patients with acquired brain damage and apathy: a study with ambulatory actigraphy. Brain Inj. 2006 Feb;20(2):157-60.
- Pasquier F, Lebert F, Lavenu I, Guillaume B. The clinical picture of frontotemporal dementia: diagnosis and follow-up. Dement Geriatr Cogn Disord. 1999;10 Suppl 1:10-4.
- Robert PH, Clairet S, Benoit M, Koutaich J, Bertogliati C, Tible O, Caci H, Borg M, Brocker P, Bedoucha P. The apathy inventory: assessment of apathy and awareness in Alzheimer's disease, Parkinson's disease and mild cognitive impairment. Int J Geriatr Psychiatry. 2002 Dec;17(12):1099-105.
- Winograd-Gurvich C, Fitzgerald PB, Georgiou-Karistianis N, Bradshaw JL, White OB. Negative symptoms: A review of schizophrenia, melancholic depression and Parkinson's disease. Brain Res Bull. 2006 Oct 16;70(4-6):312-21. Epub 2006 Jul 5. Review.
- C15-14
- 2015-A0087-42