Plethysmography Curve Variability Depending on the Breath Cycle

Sponsor

Czech Technical University in Prague (Other)

Overall Status

Recruiting

CT.gov ID

NCT05302219

Collaborator

(none)

Enrollment

Location

Arm

3.7

Anticipated Duration (Months)

5.4

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The aim of the study is to analyze the variability of plethysmography curve depending on the breath cycle (respiratory rate and tidal volume).

Condition or Disease	Intervention/Treatment	Phase
Apnea Circulatory; Change Respiration	Other: Respiratory rate Other: Tidal volume Other: Apnea	N/A

Detailed Description

The plethysmography curve measured by finger sensors using pulse oximetry shows the changes in blood volume at the measured site. The presence of respiratory information within the pulse oximeter signal is a well-documented phenomenon. However, previous studies have mainly focused on extracting the respiratory rate from the plethysmography curve. The aim of this study is to analyze the variability of plethysmography curve as a function of both respiratory rate and tidal volume. Furthermore, the aim is to analyze the possibilities of apneic pause detection from the plethysmography curve.

Study Design

Study Type:

Interventional

Anticipated Enrollment :

20 participants

Allocation:

N/A

Intervention Model:

Single Group Assignment

Intervention Model Description:

All participants go through all assigned interventions in one study arm.All participants go through all assigned interventions in one study arm.

Masking:

None (Open Label)

Primary Purpose:

Other

Official Title:

Plethysmography Curve Variability Depending on the Breath Cycle

Actual Study Start Date :

Mar 10, 2022

Anticipated Primary Completion Date :

Jun 30, 2022

Anticipated Study Completion Date :

Jun 30, 2022

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Measurement of plethysmography curve Calm measurement of plethysmography curve using pulse oximetry with simultaneous monitoring of the breath cycle. In this experimental arm, participants will vary their breath cycle (different respiratory rates and different tidal volumes).	Other: Respiratory rate The participant alternates respiratory rates of 30, 15 and 7.5 breaths/min. Breathe each frequency for 2 minutes with a one-minute break. Other: Tidal volume The participant alternates tidal volumes of approx. 2, 1 and 0.5 litres. Breathe each tidal volume for 2 minutes with a one-minute break. Other: Apnea The participant simulates three apneic pauses lasting 1 minute with a two-minute break.

Arm

Intervention/Treatment

Experimental: Measurement of plethysmography curve

Calm measurement of plethysmography curve using pulse oximetry with simultaneous monitoring of the breath cycle. In this experimental arm, participants will vary their breath cycle (different respiratory rates and different tidal volumes).

Other: Respiratory rate

The participant alternates respiratory rates of 30, 15 and 7.5 breaths/min. Breathe each frequency for 2 minutes with a one-minute break.

Other: Tidal volume

The participant alternates tidal volumes of approx. 2, 1 and 0.5 litres. Breathe each tidal volume for 2 minutes with a one-minute break.

Other: Apnea

The participant simulates three apneic pauses lasting 1 minute with a two-minute break.

Outcome Measures

Primary Outcome Measures

Variability of plethysmography curve depending on the respiratory rate [1 hour]
The effect of different respiratory rates (including apnea-zero respiratory rate) on the shape of the plethysmography curve will be evaluated.
Variability of plethysmography curve depending on the tidal volume [1 hour]
The effect of different tidal volumes (including apnea-zero tidal volume) on the shape of the plethysmography curve will be evaluated.

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 30 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

healthy volunteers/students from the Czech Technical University in Prague

Exclusion Criteria:

any acute illness
pregnancy
severe cardiovascular conditions
severe asthma or other severe respiratory conditions
diabetes
hypotension or hypertension

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Faculty of Biomedical Engineering, Czech Technical University in Prague	Kladno		Czechia	27201

Sponsors and Collaborators

Czech Technical University in Prague

Investigators

Principal Investigator: Veronika Rafl Huttova, MSc, Czech Technical University in Prague
Principal Investigator: Jakub Rafl, PhD, Czech Technical University in Prague