PEEP: Fraction of Oxygen on Induction of Anesthesia in Infants
Study Details
Study Description
Brief Summary
Invesetigators evaluated the effect of positive end-expiratory pressure during anaesthesia induction on nonhypoxic apnoea time in infants. Invesetigators assigned infants to a 7 cmH2O positive end expiratory pressure (PEEP) with fraction of inspired oxygen 80% or 0 cmH2O PEEP with fraction of oxygen 80% group. Anaesthesia was induced with 0.02 mg kg atropine, 5 mg kg thiopental sodium and 3 to 5% sevoflurane, and neuromuscular blockade with 0.6 mg kg rocuronium. Thereafter, 80% oxygen was provided via face mask with volume-controlled ventilation of 6 ml kg tidal volume, and either 7 cmH2O or no positive end-expiratory pressure. After 3 min of ventilation, the infants' trachea was intubated but disconnected from the breathing circuit, and ventilation resumed when pulse oximetry reached 95%.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Active Comparator: fraction of inspired oxygen 80%
|
Other: fraction of inspired oxygen 80%
fraction of inspired oxygen 80% applied during induction of anesthesia
|
| Experimental: Fraction of inspired oxygen 80% with positive end expiratory pressure
|
Other: positive end expiratory pressure
7cmH2O of positive end expiratory pressure with fraction of inspired oxygen 80% applied during induction of anesthesia
|
Outcome Measures
Primary Outcome Measures
- apnea time [during face mask ventilation, maximum 3 minutes.]
The primary outcome was nonhypoxic apnoea time defined as the time from cessation of ventilation to a pulse oximeter reading of 95%
Secondary Outcome Measures
- The incidence of significant atelectasis [during anesthesia induction, maximum 5 minutes.]
the incidence of significant atelectasis (consolidation score ≥2) assessed by lung ultrasound.
- Respiratory system compliance [during anesthesia induction, maximum 5 minutes.]
Respiratory system compliance (ml/H2O) = tidal volume / (airway pressure at end inspiration-airway pressure at PEEP
Eligibility Criteria
Criteria
Inclusion Criteria:
- We included paediatric patients aged 12 months or less about to receive general anaesthesia with endotracheal intubation.
Exclusion Criteria:
- Neonates, former preterm infants with gestational age less than 60 weeks at the day of surgery, with previous history of respiratory disease, those with anticipated difficult mask ventilation or intubation and those with upper respiratory infection within 3 weeks were excluded.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Hee-Soo Kim | Seoul | Soul-t'ukpyolsi | Korea, Republic of | 03080 |
Sponsors and Collaborators
- Seoul National University Hospital
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 2012-152-1184