The Effect of Volatile Anesthetics Sevoflurane and Desflurane on Liver, Renal and Cardiovascular Systems During Liver Surgery

• Sponsor: Aretaieio Hospital (Other)
• Overall Status: Unknown status
• CT.gov ID: NCT01267786
• Collaborator: (none)
• Enrollment: 40
• Location: 1
• Arms: 2

Study Details

Study Description

Brief Summary

The aim of the study is to investigate the effect of sevoflurane and desflurane on hepatic function after ischemic/reperfusion injury and the sequence influence on renal and cardiovascular systems.

Condition or Disease	Intervention/Treatment	Phase
Apoptosis; Liver Surgery	Procedure: Liver surgery	Phase 4

Study Design

• Study Type: Interventional
• Anticipated Enrollment: 40 participants
• Allocation: Randomized
• Intervention Model: Parallel Assignment
• Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
• Primary Purpose: Basic Science
• Official Title: The Effect of Volatile Anesthetics Sevoflurane and Desflurane on Liver, Renal and Cardiovascular Systems During Liver Surgery
• Study Start Date: Dec 1, 2010
• Anticipated Primary Completion Date: Dec 1, 2011

Arms and Interventions

Arm	Intervention/Treatment
Active Comparator: Sevoflurane 1MAC intraoperatively	Procedure: Liver surgery; hepatectomy
Active Comparator: desflurane 1 MAC intraoperatively	Procedure: Liver surgery; hepatectomy

Outcome Measures

Primary Outcome Measures

1. Oxidotic stress after hepatectomy. [5 d postop.]

   Perioperative liver and renal biopsies and follow up with liver renal function tests plus intraoperative and postoperative cardiovascular monitoring

Secondary Outcome Measures

1. Liver and renal dysfunction [5 d]

   liver and renal impairment due to ischemic injury

Eligibility Criteria

Criteria

• Ages Eligible for Study: 30 Years to 80 Years
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Inclusion Criteria:

• Patients undergoing liver surgery

Exclusion Criteria:

• ASA IV, Cardiovascular diseases

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Aretaieio Hospital	Athens	Attica	Greece	115 28

Sponsors and Collaborators

• Aretaieio Hospital

Investigators

• Principal Investigator: Georgios P Fragulidis, MD, Areataieio Hospital

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• ClinicalTrials.gov Identifier: NCT01267786
• Other Study ID Numbers: AnesthSurg1
• First Posted: Dec 29, 2010
• Last Update Posted: Dec 29, 2010
• Last Verified: Dec 1, 2010

• Keywords provided by , ,: Oxidotic stress

Study Results

No Results Posted as of Dec 29, 2010