TAAT: Applanation Tonometry in the Diagnosis of Giant Cell Arteritis
Study Details
Study Description
Brief Summary
The objective of this observational prospective cohort study is to assess if:
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temporal artery stiffness measurement by applanation tonometry may help predict a final diagnosis of new-onset GCA
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In patients with a diagnosis of GCA, identify if temporal artery stiffness measured by applanation tonometry improves with treatment.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
Applanation tonometry (a technique that measures the pulsation of the arteries with a probe, like ultrasound), measures the stiffness of the arteries. This technique is increasingly used for the diagnosis and monitoring of high blood pressure in routine practice. The presence of systemic inflammation, was already demonstrated to cause increased arterial stiffness, at various arterial levels, in rheumatic diseases such as rheumatoid arthritis or Takayasu's arteritis.
Objectives :
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To establish if temporal artery stiffness measurement may help predict a final diagnosis of new-onset GCA
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In patients with a diagnosis of GCA, identify if temporal artery stiffness improves with treatment
Study Design
Outcome Measures
Primary Outcome Measures
- Comparison of arterial striffness of temporal arteries in patients with vs. without new-onset GCA [Baseline]
- Comparison of arterial striffness of extra-cranial arteries in patients with vs. without new-onset GCA [Baseline]
Secondary Outcome Measures
- Assessment of variability in arterial stiffness (cranial and extra-cranial) during the course of therapy of patients with GCA [Month 3 and clinical relapse (up to 24 months after study inclusion)]
Eligibility Criteria
Criteria
Inclusion Criteria:
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Adult patients referred to our fast-track vasculitis clinic with a clinical suspicion of new-onset GCA.
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Must have a duration of glucocorticoid treatment of less than 14 days.
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Must sign informed consent
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Participation must be able to attend a 3 month follow-up visit, and in those with GCA, longitudinal clinic visits
Exclusion Criteria:
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Prior temporal artery biopsy before study enrollment
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Chronic use of immunosupressive therapy or glucocorticoids for more than 14 days
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Vasculitis Clinic, Hopital du Sacre-Coeur de Montreal | Montreal | Quebec | Canada | H4J1C5 |
Sponsors and Collaborators
- Hopital du Sacre-Coeur de Montreal
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Additional Information:
Publications
- Baalbaki H, Jalaledin D, Lachance C, Febrer G, Rheaume M, Makhzoum JP. Characterization of visual manifestations and identification of risk factors for permanent vision loss in patients with giant cell arteritis. Clin Rheumatol. 2021 Aug;40(8):3207-3217. doi: 10.1007/s10067-021-05643-5. Epub 2021 Feb 12.
- Zarka F, Rheaume M, Belhocine M, Goulet M, Febrer G, Mansour AM, Troyanov Y, Starnino T, Meunier RS, Chagnon I, Routhier N, Benard V, Ducharme-Benard S, Ross C, Makhzoum JP. Colour Doppler ultrasound and the giant cell arteritis probability score for the diagnosis of giant cell arteritis: a Canadian single-centre experience. Rheumatol Adv Pract. 2021 Nov 10;5(3):rkab083. doi: 10.1093/rap/rkab083. eCollection 2021.
- 2020-1890