The Application of Digital Infrared Thermal Imaging in Peripheral Artery Disease of the Lower Extremities
Study Details
Study Description
Brief Summary
Peripheral artery disease (PAD) is highly prevalent. It occurs most often in the lower extremities. Symptoms include intermittent claudication, ischemic pain, ulceration and necrosis. Amputation may be necessary in severe cases. PAD is also an indicator of future cerebrovascular and cardiovascular events. Diabetes mellitus (DM) is one of the major risk factors of PAD. Approximately 5% to 10% of diabetic patients have had foot ulceration, and 1% have undergone amputation. Other risk factors include smoking, old age, male gender, hypertension, dyslipidemia, hyperhomocysteinemia and renal insufficiency. Ankle-brachial index (ABI) is the most popular tool used to screen PAD. Doppler-derived ankle and brachial systolic pressure is obtained. If the ratio is abnormal, further confirmation studies will necessary. Although ABI is recommended as one of the screening tests for diabetic complications in guidelines, its utility is limited in calcified non-compressible vessels, which are common in DM and renal failure patients.
Digital infrared thermal imaging (DITI) is used to detect surface temperature because objects of absolute temperatures higher than zero would radiate electromagnetic waves of certain wave lengths according to Plank's law. DITI examination is non-invasive, non-contact and fast. Theoretically, temperature of the perfusion area of the occlusive arteries will decrease. Investigators will analyze DITI of PAD, and observe the relationship between DITI, ABI and vascular duplex examination. The dynamic change of DITI before and after percutaneous transluminal angioplasty of PAD will also be observed. Investigators would like to evaluate the possibility of the clinical application of DITI for PAD screening.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| DM with PAD before angioplasty Diabetic patients diagnosed with peripheral artery disease via vascular Duplex. |
|
| DM without PAD Diabetic patients diagnosed without peripheral artery disease via vascular Duplex. |
|
| Healthy volunteers Healthy volunteers |
|
| DM with PAD after angioplasty Diabetic patients diagnosed with PAD underwent balloon-angioplasty |
Procedure: Percutaneous balloon angioplasty
|
Outcome Measures
Primary Outcome Measures
- Digital infrared thermal imaging (DITI) [7 days]
Digital infrared thermal imaging (DITI) to detect surface temperature
Eligibility Criteria
Criteria
Inclusion Criteria:
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Age: 20~85 years old
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Diagnosed with DM
Exclusion Criteria:
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History of lower extremities disease or underwent leg surgery
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Pregnancy
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Fever
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Leg edema
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Autoimmune disease
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | National Taiwan University Hospital Taipei, Taiwan | Taipei | Taiwan |
Sponsors and Collaborators
- National Taiwan University Hospital
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 201209053RIC