Applications of MRI in Kidney Disease
Study Details
Study Description
Brief Summary
This study has two major purposes:
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To test developed multiple anatomic and functional MRI methods;
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To evaluate the potentials of these MRI methods in the diagnosis, prognosis, and monitoring of the progression of renal dysfunction.
These purposes will be achieved by performing pilot studies with cohorts of patients.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
This study is observational with no intervention applied for the patients. In this study, multiple anatomic and functional MRI methods will be performed with three cohorts of patients. In addition to anatomic MRI methods, non-contrast enhanced functional MRI methods will also be applied to evaluate tissue perfusion and vascular reactivity in these patients.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Non-CKD (Control) Patients without CKD (eGFR ≥ 60 ml/min/1.73 mm2) (non-CKD controls). No intervention but only observational. |
Other: No intervention but only observational
This study is a cross-sectional and observational MRI study with three cohorts of patients, and no interventions will be applied.
|
| CKD (chronic kidney disease) Patients with Patients with moderate to severe CKD (eGFR ranging from 26 to 44 ml/min/1.73 mm2). No intervention but only observational. |
Other: No intervention but only observational
This study is a cross-sectional and observational MRI study with three cohorts of patients, and no interventions will be applied.
|
| ESRD (end-stage renal disease) Patients with advanced CKD (eGFR < 15 ml/min/1.73 mm2), preparing for or undergoing the standard thrice-weekly HD or standard PD treatment (end-stage renal disease (ESRD) patients). No intervention but only observational. |
Other: No intervention but only observational
This study is a cross-sectional and observational MRI study with three cohorts of patients, and no interventions will be applied.
|
Outcome Measures
Primary Outcome Measures
- MRI measured perfusion for each patient group [Baseline]
MRI measurements will be summarized for each patient group by using mean and standard deviation or standard error.
Eligibility Criteria
Criteria
Inclusion Criteria:
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English-speaking as primary language
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Able to complete an approximately 75 to 90 minute cognitive and/or physical tests
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Capable to consent to studies
Exclusion Criteria:
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Acute psychiatric illness that would impede cognitive testing
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Active chemical dependence, such as alcohol, narcotics or other drugs
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Legally blind or unable to complete cognitive tests due to visual loss or deafness
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Renal transplant recipient at time of screening or baseline
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Severe CI unable to complete the Modified Mini-Mental State Examination [3MSE]
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Chronic and acute pulmonary disease
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | University of Minnesota Medical Center | Minneapolis | Minnesota | United States | 55455 |
Sponsors and Collaborators
- University of Minnesota
Investigators
- Principal Investigator: Xiufeng Li, University of Minnesota
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 1603M85321