PIANO: Population Immunity AgaiNst mosquitO-borne Diseases in Vanuatu
Study Details
Study Description
Brief Summary
The Pacific region is facing several emerging and neglected diseases notably mosquito-borne diseases as malaria or arboviroses among which dengue, Ross River, chikungunya and Zika. These diseases are an important cause of illness and death in the Pacific and the occurrence of arboviruses has increased in the recent years. In humans, these mosquito-borne diseases often have very similar clinical presentations (an acute febrile syndrome often self-limiting). However, these infections can progress to severe and fatal prognosis.
Numerous arboviroses outbreaks and in particular dengue outbreaks have affected Vanuatu for decades. Except for DENV and Zika for which epidemiological and virological data are available for Vanuatu, the knowledge on chikungunya and Ross River circulation is very limited and needs to be defined as both viruses have intensively circulated in the region in the past. Knowledge of the level of immune protection of the population for these mosquito-borne diseases is incomplete. For this purpose, seroprevalence studies that intend to retrospectively look for antibodies (IgG) as an evidence of previous infections by a specific pathogen would be highly informative. Knowing the serological profile of the Vanuatu population for dengue and other arboviruses as Ross River, chikungunya and Zika that could have affected the country in the past would be useful in defining the population likely to be infected by future epidemics.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
The PIANO project is a non-comparative observational prospective cross-sectional descriptive survey on a representative random sample of the population.
The study will be conducted on a 4-mL blood sample collected in a dry tube from 1,200 non-febrile individuals aged older than 6 years old.
The main objective of the current project is to determine the seroprevalence of dengue, Zika, chikungunya and Ross River in Vanuatu.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Other: A representative random sample of the population 1,200 non-febrile individuals aged older than 6 years old |
Other: Blood collection
a 4-mL blood sample collected in a dry tube
|
Outcome Measures
Primary Outcome Measures
- Determination of the seroprevalence of dengue, Zika, chikungunya and Ross River in Vanuatu. [1 year]
Exploration of vector-borne diseases seroprevalence in the main Provinces usually involved in outbreaks, the study will be implemented in the main cities of Efate, Santo, Tanna and Malekula Islands namely Port Vila, Luganville, Isangel and Lakatoro along with rural parts connected to the main city by main roads.
Eligibility Criteria
Criteria
Inclusion Criteria:
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Individuals informed of the research and having given their written consent to participate in the study
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Individuals aged 6 years old or more
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Individuals living in Vanuatu for more than 6 months
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Individuals informed of the research, its objectives and procedure
Exclusion Criteria:
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Tourists and people present in Vanuatu for less than 6 months
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Persons intellectually disabled or under guardianship
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Persons suffering from a febrile syndrome
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Missing information related to age or hometown
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Children weighting less than 18 kg
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Blood centers, hospitals, health facilities | Luganville | Vanuatu | ||
| 2 | Schools | Luganville | Vanuatu | ||
| 3 | Blood centers, hospitals, health facilities | Port-Vila | Vanuatu | ||
| 4 | Schools | Port-Vila | Vanuatu |
Sponsors and Collaborators
- Institut Pasteur
- Ministry of Health of Vanuatu
- Vanuatu National Hospital
Investigators
- Study Director: Myrielle Dupont-Rouzeyrol, PhD, Institut Pasteur de Nouvelle-Calédonie
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 2020-100