Paradoxical Response to Chest Wall Loading in Mechanically Ventilated Patients
Study Details
Study Description
Brief Summary
Mechanical ventilation can be a life-saving intervention for patients with respiratory failure, but the acutely injured lung is vulnerable to further damage if positive pressure ventilation is not employed judiciously. "Lung protective ventilation" encompasses a group of practices intended to minimize ventilator-induced lung injury (VILI) and includes the delivery of low tidal volumes (to minimize dynamic lung strain) and the prevention of injuriously high airway pressures (to minimize lung stress). The prone position, which compresses (or "loads") the chest wall, more evenly distributes volume and pressure, mitigates the damaging effects of stress/strain, and improves clinical outcomes in patients with severe respiratory failure from adult respiratory distress syndrome (ARDS).
Chest wall loading would not be expected to produce these beneficial effects in the supine position-quite the opposite; it usually results in net volume loss and higher airway pressures in response to an unchanging tidal volume. A paradoxical response to chest wall loading, leading to decreased airway pressures, however, was recently reported in a group of patients with advanced lung disease secondary to COVID-19. In this cohort, a paradoxical decrease in airway pressures was elicited during a brief period of manual compression of the abdomen.
This maneuver, which is non-invasive, free of cost, and gives real-time information, may have important diagnostic (and potentially therapeutic) implications for ventilator management in patients with respiratory failure.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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N/A |
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Chest wall loading All patients who are receiving mechanical ventilation and are passive on the ventilator will have chest wall loading performed to identify whether there is a paradoxical decrease in lung compliance. |
Diagnostic Test: Manual loading of the chest wall
The chest wall will be loaded by either compression of the abdominal wall, compression of the lumbar spine, or compression of the sternum.
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Outcome Measures
Primary Outcome Measures
- Lung compliance (mL/mmHg) [20 minutes total in measure duration.]
Does lung compliance improve (ie, increase) with an intervention (chest wall loading) that decreases chest wall compliance/reduces lung volume.
Eligibility Criteria
Criteria
Inclusion Criteria: Non-surgical patients admitted to the ICU at Regions Hospital (St. Paul, MN) or Methodist Hospital (St. Louis Park, MN), receiving mechanical ventilation for any reason, and breathe passively during mechanical ventilation
Exclusion Criteria:
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Age < 18 years old
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Pregnancy at the time of their inclusionary hospitalization
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Recent (< 30 days) abdominal or chest wall surgery (including spine)
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Recent (< 30 days) abdominal or chest wall trauma (including spine)
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Traumatic brain injury, intracranial bleed, or recent neurologic surgery
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Family member or representative not available to provide informed consent
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Not passive while receiving mechanical ventilation support
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Hemodynamic instability
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Regions Hospital | Saint Paul | Minnesota | United States | 55101 |
Sponsors and Collaborators
- HealthPartners Institute
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- A21-280