Effect of Electric Impedance Tomography-Guided PEEP Titration
Study Details
Study Description
Brief Summary
Acute respiratory syndrome distress (ARDS) is a clinical common syndrome with high mortality. Mechanical ventilation (MV) is the cornerstone of management of ARDS but can lead to ventilator-induced lung injury. Positive end-expiratory pressure (PEEP), as one of main component of MV, has been widely used in the clinical practice. However, how to best set PEEP is still a difficult problem for moderate to severe ARDS patients. EIT, an imaging tool evaluating the regional ventilation distribution at the bedside, can achieve the individual PEEP selection for all mechanically ventilated patients. This article compared the effect of PEEP titrated guided by EIT with fraction of inspired oxygen (FiO2)-PEEP table on the ventilation-perfusion mismatch.
Condition or Disease | Intervention/Treatment | Phase |
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N/A |
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Experimental: EIT-PEEP strategy PEEP selected by EIT which remained at 15 min |
Device: PEEP selection
Electric impedance tomography-guided PEEP titration
|
Experimental: Low FiO2-PEEP strategy PEEP selected by low FiO2-PEEP table which remained at 15 min |
Device: PEEP selection
Electric impedance tomography-guided PEEP titration
|
Experimental: High FiO2-PEEP strategy PEEP selected by high FiO2-PEEP table which remained at 15 min |
Device: PEEP selection
Electric impedance tomography-guided PEEP titration
|
Outcome Measures
Primary Outcome Measures
- Difference in ventilation-perfusion mismatch between EIT-PEEP, low-PEEP, and high PEEP [up to 24 hours]
EIT-PEEP was obtained by EIT, low-PEEP was obtained by low FIO2-PEEP table, and high-PEEP was obtained by high FIO2-PEEP table.
Secondary Outcome Measures
- difference in center of ventilation (COV) between EIT-PEEP, low-PEEP, and high PEEP [up to 24 hours]
COV was obtained by EIT monitoring
- Difference in dead space measured with EIT between EIT-PEEP, low-PEEP, and high PEEP [up to 24 hours]
dead space was obtained by EIT monitoring
- Difference in shunt measured with EIT between EIT-PEEP, low-PEEP, and high PEEP [up to 24 hours]
shunt was obtained by EIT monitoring
- Difference in wasted ventilation measured with EIT between EIT-PEEP, low-PEEP, and high PEEP [up to 24 hours]
wasted ventilation was obtained by EIT monitoring
- Difference in wasted perfusion measured with EIT between EIT-PEEP, low-PEEP, and high PEEP [up to 24 hours]
wasted perfusion was obtained by EIT monitoring
- ventilation distribution measured with EIT between EIT-PEEP, low-PEEP, and high PEEP [up to 24 hours]
ventilation distribution was obtained by EIT in difference regions
- perfusion distribution measured with EIT between EIT-PEEP, low-PEEP, and high PEEP [up to 24 hours]
perfusion distribution was obtained by EIT in difference regions
- Correlations between ventilation-perfusion mismatch and overdistension and lung collapses [up to 24 hours]
Overdistension (%) and lung collapses (%) will be assessed by EIT. These two values cannot be measured separately. V/Q mismatch will be computed by EIT, and expressed in %. Correlation will be performed by linear regression.
- recruitment-to-inflation (R/I) ratio [up to 24 hours]
recruitment-to-inflation (R/I) ratio was computed between the two PEEP levels
- PaO2/FIO2 [up to 24 hours]
PaO2/FIO2 was obtained by gas analysis
- respiratory system mechanics [up to 24 hours]
respiratory system compliance included lung compliance, chest wall compliance, and respiratory system compliance. respiratory system resistance will be computed as the inverse of compliance.
- Correlation between V/Q mismatch markers and recruitability [up to 24 hours]
Recruitability will be assessed between 15 and 5 cmH2O by respiratory mechanics, as the recruited volumes value (in mL). R/I ratio will be derived from these data (no unit). V/Q mismatch will be computed by EIT, and expressed in %. Correlation will be performed by linear regression.
Eligibility Criteria
Criteria
Inclusion Criteria:
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Intubated patients with moderate and severe ARDS (Berlin definition, PaO2/FiO2 ≤200 mmHg at PEEP 5 cmH2O)
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undergoing deep sedation on controlled mechanical ventilation within72 hours after ARDS onset
Exclusion Criteria:
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age <18 years old
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patient undergoing legal protection
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contra-indications to EIT (e. g. severe chest trauma or wounds)
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pneumothorax
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patient undergoing ECMO
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pregnancy
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | Zhongda Hospital, School of Medicine, Southeast University | Nanjing | Jiangsu | China | 210009 |
Sponsors and Collaborators
- Southeast University, China
Investigators
- Study Director: liu ling, phD, Zhongda Hospital, School of Medicine, Southeast University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- EIT-PEEPstudy