WAVE: Arterial Blood Gases in Weaning of Mechanical VEntilation
Study Details
Study Description
Brief Summary
Weaning of mechanical ventilation is an important phase of ICU (Intensive Care Unit) patient hospitalization. Patients have to pass a spontaneous breathing trial, can have a phase of pause with mechanical ventilation before extubation and then can be weaned of invasive mechanical ventilation. Spontaneous breathing trial can be performed with a T-Tube or with Pressure support without PEEP (End Expiratory Positive Pressure) . Duration of spontaneous breathing trial range from 30 minutes to 120 minutes. Some clinicians performed an arterial blood gases at the end of the spontaneous breathing trial but this practice is not really defined and clearly explained in recommendations. Patients can benefit of ventilation support after extubation like non invasive pressure support or high flow nasal canulae. The procedure can be very different from a center to another, especially for arterial blood gases at the end of spontaneous breathing trial. Our aim is to observe in a multicenter study the daily practice of weaning of mechanical ventilation especially for arterial blood gases.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Outcome Measures
Primary Outcome Measures
- Type of spontaneous breathing trial performed [In the 24 hours of spontaneous breathing trial]
Spontaneous breathing trial is performed either with pressure support or with a T-Piece
Secondary Outcome Measures
- Arterial blood gases at the end of spontaneous breathing trial [In the hour of spontaneous breathing trial]
Arterial blood gases are sometime performed at the end of the spontaneous breathing trial during weaning of mechanical ventilation. Spontaneous breathing trial takes from 30 to 120 minutes
- Duration of spontaneous breathing trial [The day of the spontaneous breathing trial]
Duration in minutes
- Ventilatory procedure at the end of spontaneous breathing trial: either immediate extubation or pressure support ventilation with intubation [The day of extubation if extubation performed]
the procedure at the end of spontaneous: the patient is either extubated immediately or benefit of about one hour of invasive pressure support with the settings before spontaneous breathing trial until extubation. Procedure of extubation is differed of about one hour.
- Frequency and type of ventilatory support after extubation [The day of extubation if extubation performed]
Ventilatory is either not performed or if performed, with pressure support or high flow oxygen nasal canulae
- Need for reintubation [During the seven days following extubation]
Reintubation is the need to reintubate the patient because of extubation failure
- Etiology of reintubation [During the seven days following extubation]
The cause of reintubation (pulmonary edema, infectious pulmonary disease...)
- Death [The first 28 days following extubation]
If the patient died
- Ventilator associated pneumoniae [From 48 hours after extubation until extubation]
Pneumoniae acquired after more than 48 hours of mechanical ventilation
- days alive without mechanical ventilation [during the first 28 days of intensive care hospitalization.]
The number of days without invasive mechanical ventilation support during the first 28 days of intensive care hospitalization.
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Older than 18 years
-
first attempt of weaning of mechanical ventilation
Exclusion Criteria:
-
withholding of life sustaining therapies
-
spontaneous breathing trial unsuccessful
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | BARROT | Besançon | France | 25320 |
Sponsors and Collaborators
- Centre Hospitalier Universitaire de Besancon
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- CHUB WAVE