RAIPAo: Relationship Between Aortic Parietal Inflammation on 18F-FDG PET Scan and Arterial Stiffness as a Function of Age

• Sponsor: Central Hospital, Nancy, France (Other)
• Overall Status: Completed
• CT.gov ID: NCT06151054
• Collaborator: (none)
• Enrollment: 89
• Location: 1
• Actual Duration (Months): 1.2
• Patients Per Site Per Month: 73.2

Study Details

Study Description

Brief Summary

Show that there is a relationship between arterial stiffness and aortic parietal inflammation and that this relationship is different in the three age groups with aortic parietal inflammation occurring earlier than arterial stiffness.

Condition or Disease	Intervention/Treatment	Phase
Arterial Stiffness	Diagnostic Test: Measure of aortic inflammation

Detailed Description

In the literature, a relationship has been demonstrated between local inflammation in the aortic wall and increased arterial stiffness. Arterial stiffness is commonly represented by pulse wave velocity (PWV) measured using an applanation tonometer. It would seem that this parietal inflammation precedes arterial stiffness and consequently, arterial hypertension . Arterial stiffness is an important factor of cardiovascular morbidity and mortality and therefore represents a major public health interest in prevention in the face of the continuous aging of our population . This study will consist in studying on a population divided into three age groups, less than 40 years old, 40 to 60 years old and more than 60 years old, the relationship between thoracic aortic parietal inflammation evaluated using the Standard Uptake Value parameters (SUV) and Hounsfield units (HU) measured on 18F-FDG PET/CT scans performed between 09/04/2018 and 11/06/2020 and arterial stiffness parameters. We will seek to show that there is a relationship between arterial stiffness and aortic parietal inflammation and that this relationship is different in the three age groups with aortic parietal inflammation occurring earlier than arterial stiffness.

Study Design

• Study Type: Observational [Patient Registry]
• Actual Enrollment: 89 participants
• Observational Model: Cohort
• Time Perspective: Other
• Official Title: Relationship Between Aortic Parietal Inflammation on 18F-FDG PET Scan and Arterial Stiffness as a Function of Age
• Actual Study Start Date: Oct 30, 2022
• Actual Primary Completion Date: Nov 30, 2022
• Actual Study Completion Date: Dec 6, 2022

Outcome Measures

Primary Outcome Measures

1. to etablish a relationship inflammation of aortic wall and arterial stiffness [1 day]

   Standard Uptake Value

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years to 95 Years
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Inclusion Criteria:

• Patients who underwent whole-body 18F-FDG PET/CT included in the PACTEP study

• Patient with an assessment of arterial stiffness by applanation tonometer

Exclusion Criteria:

• patients without an assessment of arterial stiffness by applanation tonometer

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	CHRU Nancy	Vandoeuvre les Nancy cedex		France	54511

Sponsors and Collaborators

• Central Hospital, Nancy, France

Investigators

• Study Director: Anne-Sophie HUE, MSc, CHRU Nancy

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: Pierre Yves MARIE, professor, Central Hospital, Nancy, France
• ClinicalTrials.gov Identifier: NCT06151054
• Other Study ID Numbers: 2022PI141
• First Posted: Nov 30, 2023
• Last Update Posted: Nov 30, 2023
• Last Verified: Nov 1, 2023

• Studies a U.S. FDA-regulated Drug Product: No
• Studies a U.S. FDA-regulated Device Product: No
• Additional relevant MeSH terms: Inflammation

Study Results

No Results Posted as of Nov 30, 2023