AIortho: Artificial Intelligence in the Diagnosis of Orthopaedic Conditions, Particularly Bone Tumours and Infection
Sponsor
Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust (Other)
Overall Status
Enrolling by invitation
CT.gov ID
NCT04746001
Collaborator
Keele University (Other)
100
1
36.1
2.8
Study Details
Study Description
Brief Summary
Translational research aimed at improving diagnostic accuracy of musculoskeletal infection and musculoskeletal tumours using machine learning applied to clinical data, histopathological sections and genomic sequencing.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Study Type:
Observational
Anticipated Enrollment
:
100 participants
Observational Model:
Case-Only
Time Perspective:
Prospective
Official Title:
Artificial Intelligence in the Diagnosis of Orthopaedic Conditions, Particularly Bone Tumours and Infection
Actual Study Start Date
:
Jun 28, 2021
Anticipated Primary Completion Date
:
Jan 1, 2024
Anticipated Study Completion Date
:
Jul 1, 2024
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Infection
|
Diagnostic Test: Genomic sequencing
Sequencing data
Diagnostic Test: Histological examination
Images for deep learning
|
| Tumours
|
Diagnostic Test: Genomic sequencing
Sequencing data
Diagnostic Test: Histological examination
Images for deep learning
|
Outcome Measures
Primary Outcome Measures
- Sequencing data and identification [3 years]
Identification of infection and tumours using sequencing data
- Histological slides and identification [3 years]
Deep learning using histological images
Eligibility Criteria
Criteria
Ages Eligible for Study:
18 Years
and Older
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria:
Suspected infection of bone tumour and biopsy taken for analysis
Exclusion Criteria:
Patient doesn't consent
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Trust | Oswestry | Shropsire | United Kingdom | SY10 7AG |
Sponsors and Collaborators
- Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust
- Keele University
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.Responsible Party:
Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust
ClinicalTrials.gov Identifier:
NCT04746001
Other Study ID Numbers:
- 281854_47208_2021
First Posted:
Feb 9, 2021
Last Update Posted:
Nov 11, 2021
Last Verified:
Nov 1, 2021
Individual Participant Data (IPD) Sharing Statement:
Undecided
Plan to Share IPD:
Undecided
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Additional relevant MeSH terms: