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DOSI: Assessing Cerebrovascular Reactivity Based on Cerebral Oximetry: a Pilot Study

Sponsor
University of California, Irvine (Other)
Overall Status
Completed
CT.gov ID
NCT01483495
Collaborator
Beckman Laser Institute University of California Irvine (Other)
78
Enrollment
1
Location

Study Details

Study Description

Brief Summary

The brain is such a metabolically active organ that it consumes about 20% of oxygen burned every minute by an average adult even though it only contributes about 2% of the body weight. As a result, the brain produces a disproportionately high amount of CO2 every minute in comparison with the rest of the body.

Condition or Disease Intervention/Treatment Phase
  • Device: Diffuse optical spectroscopy

Detailed Description

The researcher can use Diffuse Optical Spectroscopy Imaging, cerebral non-invasive oximetry instrument, to determine cerebrovascular reactivity during surgery procedure. Specifically, the cerebral tissue O2 saturation can measure by Diffuse Optical Spectroscopy Imaging can use for cerebral blood flow in the evaluation of cerebrovascular reactivity.

Adequate brain perfusion is critical not only to supply oxygen and nutrients but also to wash out metabolic end products including CO2. Blood flow depends on perfusion pressure and vascular bed resistance. It is well known that multiple physiological and pathological factors affect cerebral vasculature, and the resistance to blood flow. The cerebrovascular responsiveness to those factors determines how well the brain can maintain and adjust its perfusion.

Study Design

Study Type:
Observational
Actual Enrollment :
78 participants
Observational Model:
Case-Control
Time Perspective:
Cross-Sectional
Official Title:
Assessing Cerebrovascular Reactivity Based on Cerebral Oximetry
Study Start Date :
Dec 1, 2011
Actual Primary Completion Date :
Dec 1, 2011
Actual Study Completion Date :
Dec 1, 2011

Arms and Interventions

Arm Intervention/Treatment
Diagnostic tool

Diffuse Optical Spectroscopy Imaging Cerebrovascular Reactivity

Device: Diffuse optical spectroscopy
Diffuse Optical Spectroscopy Imaging Cerebrovascular Reactivity
Other Names:
  • Diffuse Optical Spectroscopy Imaging

    		•

    Outcome Measures

    Primary Outcome Measures

    1. Brain blood flow [6 hours]

      Optical Imaging assess of Brain blood flow during surgical procedure

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    20 Years and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:

    1. Male or Female 20 years of age and older

    2. Female non-pregnant

    3. Subject scheduled for elective surgery under general anesthesia with intubation.

    4. Subject who is able to give informed consent.

    Exclusion Criteria:

    1. Less than 20 years old of age

    2. Pregnant woman

    3. Subjects currently diagnosed with severe hypertension, myocardial ischemic disease, symptomatic valvular disease(s), symptomatic arrhythmia, uncompensated congestive heart failure, intracranial aneurysm.

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 UCI Beckman Laser Institute Irvine California United States 92612

    Sponsors and Collaborators

    • University of California, Irvine
    • Beckman Laser Institute University of California Irvine

    Investigators

    • Study Director: Bruce Tromberg, PhD, Beckman Laser Institute
    • Principal Investigator: Lingzhong Meng, M.D, Anesthesiology Perioperative Care

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Beckman Laser Institute and Medical Center, Lingzhong Meng, M.D.,Assistant Clinical Professor and Director of Neuroanesthesia, University of California, Irvine
    ClinicalTrials.gov Identifier:
    NCT01483495
    Other Study ID Numbers:
    • NIH-LAMMP-2010-7521
    First Posted:
    Dec 1, 2011
    Last Update Posted:
    Feb 10, 2017
    Last Verified:
    Feb 1, 2017
    Additional relevant MeSH terms:
    Brain Ischemia
    Hypoxia-Ischemia, Brain
    Ischemia
    Hypoxia

    Study Results

    No Results Posted as of Feb 10, 2017